| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CopR_1 | irlS | HMPREF0758_0901 | HMPREF0758_2943 | Response regulator receiver domain protein; COG: COG0745; Pfam: PF00072,PF00486; InterPro: IPR001789. | Heavy metal sensor kinase; Member of a two-component regulatory system. | 0.821 |
| CopR_1 | qseB2 | HMPREF0758_0901 | HMPREF0758_2050 | Response regulator receiver domain protein; COG: COG0745; Pfam: PF00072,PF00486; InterPro: IPR001789. | Response regulator receiver domain protein; COG: COG0745; Pfam: PF00072,PF00486; InterPro: IPR001789. | 0.917 |
| CopR_1 | qseB3 | HMPREF0758_0901 | HMPREF0758_2159 | Response regulator receiver domain protein; COG: COG0745; Pfam: PF00072,PF00486; InterPro: IPR001789. | Response regulator receiver domain protein; COG: COG0745; Pfam: PF00072,PF00486; InterPro: IPR001789. | 0.914 |
| cpxR | irlS | HMPREF0758_1232 | HMPREF0758_2943 | Transcriptional regulatory protein CpxR; COG: COG0745; Pfam: PF00072,PF00486; InterPro: IPR001789. | Heavy metal sensor kinase; Member of a two-component regulatory system. | 0.806 |
| creB | irlS | HMPREF0758_2230 | HMPREF0758_2943 | Response regulator receiver domain protein; COG: COG0745; Pfam: PF00072,PF00486; InterPro: IPR001789. | Heavy metal sensor kinase; Member of a two-component regulatory system. | 0.806 |
| irlR | irlS | HMPREF0758_2942 | HMPREF0758_2943 | Heavy metal response regulator; COG: COG0745; Pfam: PF00072,PF00486; InterPro: IPR006291. | Heavy metal sensor kinase; Member of a two-component regulatory system. | 0.996 |
| irlS | CopR_1 | HMPREF0758_2943 | HMPREF0758_0901 | Heavy metal sensor kinase; Member of a two-component regulatory system. | Response regulator receiver domain protein; COG: COG0745; Pfam: PF00072,PF00486; InterPro: IPR001789. | 0.821 |
| irlS | cpxR | HMPREF0758_2943 | HMPREF0758_1232 | Heavy metal sensor kinase; Member of a two-component regulatory system. | Transcriptional regulatory protein CpxR; COG: COG0745; Pfam: PF00072,PF00486; InterPro: IPR001789. | 0.806 |
| irlS | creB | HMPREF0758_2943 | HMPREF0758_2230 | Heavy metal sensor kinase; Member of a two-component regulatory system. | Response regulator receiver domain protein; COG: COG0745; Pfam: PF00072,PF00486; InterPro: IPR001789. | 0.806 |
| irlS | irlR | HMPREF0758_2943 | HMPREF0758_2942 | Heavy metal sensor kinase; Member of a two-component regulatory system. | Heavy metal response regulator; COG: COG0745; Pfam: PF00072,PF00486; InterPro: IPR006291. | 0.996 |
| irlS | ompR2 | HMPREF0758_2943 | HMPREF0758_2654 | Heavy metal sensor kinase; Member of a two-component regulatory system. | Response regulator receiver domain protein; COG: COG0745; Pfam: PF00072,PF00486; InterPro: IPR001789. | 0.804 |
| irlS | qseB | HMPREF0758_2943 | HMPREF0758_0815 | Heavy metal sensor kinase; Member of a two-component regulatory system. | Response regulator receiver domain protein; COG: COG0745; Pfam: PF00072,PF00486; InterPro: IPR001789. | 0.829 |
| irlS | qseB2 | HMPREF0758_2943 | HMPREF0758_2050 | Heavy metal sensor kinase; Member of a two-component regulatory system. | Response regulator receiver domain protein; COG: COG0745; Pfam: PF00072,PF00486; InterPro: IPR001789. | 0.826 |
| irlS | qseB3 | HMPREF0758_2943 | HMPREF0758_2159 | Heavy metal sensor kinase; Member of a two-component regulatory system. | Response regulator receiver domain protein; COG: COG0745; Pfam: PF00072,PF00486; InterPro: IPR001789. | 0.808 |
| irlS | resD | HMPREF0758_2943 | HMPREF0758_2015 | Heavy metal sensor kinase; Member of a two-component regulatory system. | Response regulator receiver domain protein; COG: COG0745; Pfam: PF00072,PF00486; InterPro: IPR001789. | 0.825 |
| irlS | tctD | HMPREF0758_2943 | HMPREF0758_2750 | Heavy metal sensor kinase; Member of a two-component regulatory system. | Response regulator receiver domain protein; COG: COG0745; Pfam: PF00072,PF00486; InterPro: IPR001789. | 0.819 |
| ompR2 | irlS | HMPREF0758_2654 | HMPREF0758_2943 | Response regulator receiver domain protein; COG: COG0745; Pfam: PF00072,PF00486; InterPro: IPR001789. | Heavy metal sensor kinase; Member of a two-component regulatory system. | 0.804 |
| qseB | irlS | HMPREF0758_0815 | HMPREF0758_2943 | Response regulator receiver domain protein; COG: COG0745; Pfam: PF00072,PF00486; InterPro: IPR001789. | Heavy metal sensor kinase; Member of a two-component regulatory system. | 0.829 |
| qseB2 | CopR_1 | HMPREF0758_2050 | HMPREF0758_0901 | Response regulator receiver domain protein; COG: COG0745; Pfam: PF00072,PF00486; InterPro: IPR001789. | Response regulator receiver domain protein; COG: COG0745; Pfam: PF00072,PF00486; InterPro: IPR001789. | 0.917 |
| qseB2 | irlS | HMPREF0758_2050 | HMPREF0758_2943 | Response regulator receiver domain protein; COG: COG0745; Pfam: PF00072,PF00486; InterPro: IPR001789. | Heavy metal sensor kinase; Member of a two-component regulatory system. | 0.826 |