| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DapA_2 | RhmT_5 | HMPREF0758_2989 | HMPREF0758_2988 | Dihydrodipicolinate synthetase family; COG: COG0329; Pfam: PF00701; InterPro: IPR013785; Belongs to the DapA family. | Transporter, major facilitator family protein; Pfam: PF07690,PF00389,PF02826; InterPro: IPR011701. | 0.638 |
| DapA_2 | asd | HMPREF0758_2989 | HMPREF0758_1065 | Dihydrodipicolinate synthetase family; COG: COG0329; Pfam: PF00701; InterPro: IPR013785; Belongs to the DapA family. | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | 0.936 |
| DapA_2 | dapA | HMPREF0758_2989 | HMPREF0758_2601 | Dihydrodipicolinate synthetase family; COG: COG0329; Pfam: PF00701; InterPro: IPR013785; Belongs to the DapA family. | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | 0.918 |
| DapA_2 | dapA-2 | HMPREF0758_2989 | HMPREF0758_3895 | Dihydrodipicolinate synthetase family; COG: COG0329; Pfam: PF00701; InterPro: IPR013785; Belongs to the DapA family. | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | 0.938 |
| DapA_2 | dapB | HMPREF0758_2989 | HMPREF0758_0567 | Dihydrodipicolinate synthetase family; COG: COG0329; Pfam: PF00701; InterPro: IPR013785; Belongs to the DapA family. | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. | 0.969 |
| DapA_2 | metL | HMPREF0758_2989 | HMPREF0758_1159 | Dihydrodipicolinate synthetase family; COG: COG0329; Pfam: PF00701; InterPro: IPR013785; Belongs to the DapA family. | Homoserine dehydrogenase; COG: COG0460; Pfam: PF00742; InterPro: IPR001342. | 0.548 |
| DapA_2 | metM2 | HMPREF0758_2989 | HMPREF0758_1160 | Dihydrodipicolinate synthetase family; COG: COG0329; Pfam: PF00701; InterPro: IPR013785; Belongs to the DapA family. | Amino acid kinase family; COG: COG0527; Pfam: PF00696; InterPro: IPR001341. | 0.952 |
| DapA_2 | pheA | HMPREF0758_2989 | HMPREF0758_0402 | Dihydrodipicolinate synthetase family; COG: COG0329; Pfam: PF00701; InterPro: IPR013785; Belongs to the DapA family. | Chorismate mutase; COG: COG0077; Pfam: PF01817,PF00800; InterPro: IPR001086. | 0.580 |
| DapA_2 | rbsK-2 | HMPREF0758_2989 | HMPREF0758_2990 | Dihydrodipicolinate synthetase family; COG: COG0329; Pfam: PF00701; InterPro: IPR013785; Belongs to the DapA family. | Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. | 0.664 |
| DapA_2 | thrA | HMPREF0758_2989 | HMPREF0758_0591 | Dihydrodipicolinate synthetase family; COG: COG0329; Pfam: PF00701; InterPro: IPR013785; Belongs to the DapA family. | Homoserine dehydrogenase; COG: COG0527; Pfam: PF00696,PF01842,PF03447,PF00742; InterPro: IPR001341; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.952 |
| RhmT_5 | DapA_2 | HMPREF0758_2988 | HMPREF0758_2989 | Transporter, major facilitator family protein; Pfam: PF07690,PF00389,PF02826; InterPro: IPR011701. | Dihydrodipicolinate synthetase family; COG: COG0329; Pfam: PF00701; InterPro: IPR013785; Belongs to the DapA family. | 0.638 |
| RhmT_5 | rbsK-2 | HMPREF0758_2988 | HMPREF0758_2990 | Transporter, major facilitator family protein; Pfam: PF07690,PF00389,PF02826; InterPro: IPR011701. | Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. | 0.523 |
| asd | DapA_2 | HMPREF0758_1065 | HMPREF0758_2989 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | Dihydrodipicolinate synthetase family; COG: COG0329; Pfam: PF00701; InterPro: IPR013785; Belongs to the DapA family. | 0.936 |
| asd | dapA | HMPREF0758_1065 | HMPREF0758_2601 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | 0.939 |
| asd | dapA-2 | HMPREF0758_1065 | HMPREF0758_3895 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | 0.939 |
| asd | dapB | HMPREF0758_1065 | HMPREF0758_0567 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. | 0.517 |
| asd | metL | HMPREF0758_1065 | HMPREF0758_1159 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | Homoserine dehydrogenase; COG: COG0460; Pfam: PF00742; InterPro: IPR001342. | 0.897 |
| asd | metM2 | HMPREF0758_1065 | HMPREF0758_1160 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | Amino acid kinase family; COG: COG0527; Pfam: PF00696; InterPro: IPR001341. | 0.989 |
| asd | pheA | HMPREF0758_1065 | HMPREF0758_0402 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | Chorismate mutase; COG: COG0077; Pfam: PF01817,PF00800; InterPro: IPR001086. | 0.493 |
| asd | thrA | HMPREF0758_1065 | HMPREF0758_0591 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | Homoserine dehydrogenase; COG: COG0527; Pfam: PF00696,PF01842,PF03447,PF00742; InterPro: IPR001341; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.989 |