| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EFE95332.1 | agr_PAT | HMPREF0758_3023 | HMPREF0758_3025 | Hypothetical protein; COG: COG3616. | Endoribonuclease L-PSP; COG: COG0251; Pfam: PF01042; InterPro: IPR013813. | 0.846 |
| EFE95332.1 | dsdA | HMPREF0758_3023 | HMPREF0758_3682 | Hypothetical protein; COG: COG3616. | D-serine ammonia-lyase; COG: COG3048; Pfam: PF00291; InterPro: IPR011780. | 0.900 |
| EFE95332.1 | gloA-2 | HMPREF0758_3023 | HMPREF0758_3920 | Hypothetical protein; COG: COG3616. | Lactoylglutathione lyase; COG: COG0346; Pfam: PF00903; InterPro: IPR004361. | 0.805 |
| EFE95332.1 | ilvA | HMPREF0758_3023 | HMPREF0758_1130 | Hypothetical protein; COG: COG3616. | Threonine ammonia-lyase, biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.907 |
| EFE95332.1 | ndeD | HMPREF0758_3023 | HMPREF0758_3024 | Hypothetical protein; COG: COG3616. | Amidohydrolase family protein; COG: COG3653; Pfam: PF07969,PF07908; InterPro: IPR013108. | 0.912 |
| EFE95332.1 | pdxB | HMPREF0758_3023 | HMPREF0758_1387 | Hypothetical protein; COG: COG3616. | 4-phosphoerythronate dehydrogenase; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily. | 0.806 |
| EFE95332.1 | pdxB-3 | HMPREF0758_3023 | HMPREF0758_3399 | Hypothetical protein; COG: COG3616. | 4-phosphoerythronate dehydrogenase; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. | 0.800 |
| EFE95332.1 | sdaA | HMPREF0758_3023 | HMPREF0758_3329 | Hypothetical protein; COG: COG3616. | L-serine ammonia-lyase; COG: COG1760; Pfam: PF03315,PF03313; InterPro: IPR004644; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.901 |
| EFE95332.1 | sdaA2 | HMPREF0758_3023 | HMPREF0758_4523 | Hypothetical protein; COG: COG3616. | L-serine ammonia-lyase; COG: COG1760; Pfam: PF03315,PF03313; InterPro: IPR004644; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.901 |
| EFE95332.1 | tdcB | HMPREF0758_3023 | HMPREF0758_1370 | Hypothetical protein; COG: COG3616. | Pyridoxal-phosphate dependent protein; COG: COG1171; Pfam: PF00291; InterPro: IPR001926. | 0.907 |
| agr_PAT | EFE95332.1 | HMPREF0758_3025 | HMPREF0758_3023 | Endoribonuclease L-PSP; COG: COG0251; Pfam: PF01042; InterPro: IPR013813. | Hypothetical protein; COG: COG3616. | 0.846 |
| agr_PAT | ndeD | HMPREF0758_3025 | HMPREF0758_3024 | Endoribonuclease L-PSP; COG: COG0251; Pfam: PF01042; InterPro: IPR013813. | Amidohydrolase family protein; COG: COG3653; Pfam: PF07969,PF07908; InterPro: IPR013108. | 0.903 |
| dsdA | EFE95332.1 | HMPREF0758_3682 | HMPREF0758_3023 | D-serine ammonia-lyase; COG: COG3048; Pfam: PF00291; InterPro: IPR011780. | Hypothetical protein; COG: COG3616. | 0.900 |
| dsdA | gloA-2 | HMPREF0758_3682 | HMPREF0758_3920 | D-serine ammonia-lyase; COG: COG3048; Pfam: PF00291; InterPro: IPR011780. | Lactoylglutathione lyase; COG: COG0346; Pfam: PF00903; InterPro: IPR004361. | 0.800 |
| dsdA | ilvA | HMPREF0758_3682 | HMPREF0758_1130 | D-serine ammonia-lyase; COG: COG3048; Pfam: PF00291; InterPro: IPR011780. | Threonine ammonia-lyase, biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.909 |
| dsdA | pdxB | HMPREF0758_3682 | HMPREF0758_1387 | D-serine ammonia-lyase; COG: COG3048; Pfam: PF00291; InterPro: IPR011780. | 4-phosphoerythronate dehydrogenase; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily. | 0.800 |
| dsdA | pdxB-3 | HMPREF0758_3682 | HMPREF0758_3399 | D-serine ammonia-lyase; COG: COG3048; Pfam: PF00291; InterPro: IPR011780. | 4-phosphoerythronate dehydrogenase; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. | 0.800 |
| dsdA | sdaA | HMPREF0758_3682 | HMPREF0758_3329 | D-serine ammonia-lyase; COG: COG3048; Pfam: PF00291; InterPro: IPR011780. | L-serine ammonia-lyase; COG: COG1760; Pfam: PF03315,PF03313; InterPro: IPR004644; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.913 |
| dsdA | sdaA2 | HMPREF0758_3682 | HMPREF0758_4523 | D-serine ammonia-lyase; COG: COG3048; Pfam: PF00291; InterPro: IPR011780. | L-serine ammonia-lyase; COG: COG1760; Pfam: PF03315,PF03313; InterPro: IPR004644; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.913 |
| dsdA | tdcB | HMPREF0758_3682 | HMPREF0758_1370 | D-serine ammonia-lyase; COG: COG3048; Pfam: PF00291; InterPro: IPR011780. | Pyridoxal-phosphate dependent protein; COG: COG1171; Pfam: PF00291; InterPro: IPR001926. | 0.909 |