| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| arsB | arsC-2 | HMPREF0758_3144 | HMPREF0758_3145 | Arsenical pump membrane protein; Involved in arsenical resistance. Thought to form the channel of an arsenite pump; Belongs to the ArsB family. | Arsenate reductase; COG: COG1393; Pfam: PF03960; InterPro: IPR012335. | 0.762 |
| arsB | umuD | HMPREF0758_3144 | HMPREF0758_3146 | Arsenical pump membrane protein; Involved in arsenical resistance. Thought to form the channel of an arsenite pump; Belongs to the ArsB family. | Peptidase S24-like protein; COG: COG1974; Pfam: PF00717; InterPro: IPR011056; Belongs to the peptidase S24 family. | 0.425 |
| arsC-2 | arsB | HMPREF0758_3145 | HMPREF0758_3144 | Arsenate reductase; COG: COG1393; Pfam: PF03960; InterPro: IPR012335. | Arsenical pump membrane protein; Involved in arsenical resistance. Thought to form the channel of an arsenite pump; Belongs to the ArsB family. | 0.762 |
| arsC-2 | umuD | HMPREF0758_3145 | HMPREF0758_3146 | Arsenate reductase; COG: COG1393; Pfam: PF03960; InterPro: IPR012335. | Peptidase S24-like protein; COG: COG1974; Pfam: PF00717; InterPro: IPR011056; Belongs to the peptidase S24 family. | 0.486 |
| dinB | polA | HMPREF0758_0322 | HMPREF0758_1303 | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.659 |
| dinB | recA | HMPREF0758_0322 | HMPREF0758_0426 | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.543 |
| dinB | umuD | HMPREF0758_0322 | HMPREF0758_3146 | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | Peptidase S24-like protein; COG: COG1974; Pfam: PF00717; InterPro: IPR011056; Belongs to the peptidase S24 family. | 0.735 |
| polA | dinB | HMPREF0758_1303 | HMPREF0758_0322 | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | 0.659 |
| polA | recA | HMPREF0758_1303 | HMPREF0758_0426 | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.965 |
| polA | recN | HMPREF0758_1303 | HMPREF0758_2439 | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | 0.541 |
| polA | umuC | HMPREF0758_1303 | HMPREF0758_2081 | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | Putative DNA polymerase V subunit UmuC; COG: COG0389; Pfam: PF00817; InterPro: IPR001126. | 0.659 |
| polA | umuC2 | HMPREF0758_1303 | HMPREF0758_3147 | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | Putative DNA polymerase V subunit UmuC; COG: COG0389; Pfam: PF00817; InterPro: IPR001126; Belongs to the DNA polymerase type-Y family. | 0.659 |
| polA | umuD | HMPREF0758_1303 | HMPREF0758_3146 | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | Peptidase S24-like protein; COG: COG1974; Pfam: PF00717; InterPro: IPR011056; Belongs to the peptidase S24 family. | 0.400 |
| recA | dinB | HMPREF0758_0426 | HMPREF0758_0322 | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | 0.543 |
| recA | polA | HMPREF0758_0426 | HMPREF0758_1303 | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.965 |
| recA | recN | HMPREF0758_0426 | HMPREF0758_2439 | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | 0.795 |
| recA | sulA2 | HMPREF0758_0426 | HMPREF0758_4337 | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | Cell division inhibitor SulA; Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. | 0.541 |
| recA | umuC | HMPREF0758_0426 | HMPREF0758_2081 | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | Putative DNA polymerase V subunit UmuC; COG: COG0389; Pfam: PF00817; InterPro: IPR001126. | 0.543 |
| recA | umuC2 | HMPREF0758_0426 | HMPREF0758_3147 | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | Putative DNA polymerase V subunit UmuC; COG: COG0389; Pfam: PF00817; InterPro: IPR001126; Belongs to the DNA polymerase type-Y family. | 0.543 |
| recA | umuD | HMPREF0758_0426 | HMPREF0758_3146 | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | Peptidase S24-like protein; COG: COG1974; Pfam: PF00717; InterPro: IPR011056; Belongs to the peptidase S24 family. | 0.874 |