| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| YebF | tex | HMPREF0758_3340 | HMPREF0758_3339 | YebF family protein. | ASCH domain protein; COG: COG3097; Pfam: PF06164; InterPro: IPR008314; Belongs to the UPF0267 family. | 0.694 |
| YebF | yebG | HMPREF0758_3340 | HMPREF0758_3338 | YebF family protein. | YebG protein; COG: COG3141; Pfam: PF07130; InterPro: IPR009813. | 0.741 |
| dbpA | tex | HMPREF0758_3337 | HMPREF0758_3339 | DEAD/DEAH box helicase; DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3' to 5' RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes. | ASCH domain protein; COG: COG3097; Pfam: PF06164; InterPro: IPR008314; Belongs to the UPF0267 family. | 0.460 |
| dbpA | yebG | HMPREF0758_3337 | HMPREF0758_3338 | DEAD/DEAH box helicase; DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3' to 5' RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes. | YebG protein; COG: COG3141; Pfam: PF07130; InterPro: IPR009813. | 0.543 |
| lexA | recA | HMPREF0758_1708 | HMPREF0758_0426 | Repressor LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single- stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.859 |
| lexA | recN | HMPREF0758_1708 | HMPREF0758_2439 | Repressor LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single- stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | 0.598 |
| lexA | sulA2 | HMPREF0758_1708 | HMPREF0758_4337 | Repressor LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single- stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | Cell division inhibitor SulA; Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. | 0.467 |
| lexA | yebG | HMPREF0758_1708 | HMPREF0758_3338 | Repressor LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single- stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | YebG protein; COG: COG3141; Pfam: PF07130; InterPro: IPR009813. | 0.547 |
| recA | lexA | HMPREF0758_0426 | HMPREF0758_1708 | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | Repressor LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single- stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.859 |
| recA | recN | HMPREF0758_0426 | HMPREF0758_2439 | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | 0.795 |
| recA | sulA2 | HMPREF0758_0426 | HMPREF0758_4337 | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | Cell division inhibitor SulA; Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. | 0.541 |
| recA | umuD | HMPREF0758_0426 | HMPREF0758_3146 | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | Peptidase S24-like protein; COG: COG1974; Pfam: PF00717; InterPro: IPR011056; Belongs to the peptidase S24 family. | 0.874 |
| recA | yebG | HMPREF0758_0426 | HMPREF0758_3338 | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | YebG protein; COG: COG3141; Pfam: PF07130; InterPro: IPR009813. | 0.535 |
| recN | lexA | HMPREF0758_2439 | HMPREF0758_1708 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | Repressor LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single- stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.598 |
| recN | recA | HMPREF0758_2439 | HMPREF0758_0426 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.795 |
| recN | sulA2 | HMPREF0758_2439 | HMPREF0758_4337 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | Cell division inhibitor SulA; Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. | 0.815 |
| recN | umuD | HMPREF0758_2439 | HMPREF0758_3146 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | Peptidase S24-like protein; COG: COG1974; Pfam: PF00717; InterPro: IPR011056; Belongs to the peptidase S24 family. | 0.564 |
| recN | yebG | HMPREF0758_2439 | HMPREF0758_3338 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | YebG protein; COG: COG3141; Pfam: PF07130; InterPro: IPR009813. | 0.576 |
| sulA2 | lexA | HMPREF0758_4337 | HMPREF0758_1708 | Cell division inhibitor SulA; Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. | Repressor LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single- stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.467 |
| sulA2 | recA | HMPREF0758_4337 | HMPREF0758_0426 | Cell division inhibitor SulA; Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.541 |