| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| LsrF | PfkA_2 | HMPREF0758_3362 | HMPREF0758_3845 | Deoxyribose-phosphate aldolase; COG: COG1830; Pfam: PF01791; InterPro: IPR013785. | Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. | 0.914 |
| LsrF | fbaA | HMPREF0758_3362 | HMPREF0758_2200 | Deoxyribose-phosphate aldolase; COG: COG1830; Pfam: PF01791; InterPro: IPR013785. | Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. | 0.912 |
| LsrF | fbp | HMPREF0758_3362 | HMPREF0758_0830 | Deoxyribose-phosphate aldolase; COG: COG1830; Pfam: PF01791; InterPro: IPR013785. | Fructose-1,6-bisphosphatase; COG: COG0158; Pfam: PF00316; InterPro: IPR000146; Belongs to the FBPase class 1 family. | 0.918 |
| LsrF | gap | HMPREF0758_3362 | HMPREF0758_3492 | Deoxyribose-phosphate aldolase; COG: COG1830; Pfam: PF01791; InterPro: IPR013785. | Glyceraldehyde-3-phosphate dehydrogenase, type I; COG: COG0057; Pfam: PF00044,PF02800; InterPro: IPR000173; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. | 0.914 |
| LsrF | lsrG | HMPREF0758_3362 | HMPREF0758_4742 | Deoxyribose-phosphate aldolase; COG: COG1830; Pfam: PF01791; InterPro: IPR013785. | Antibiotic biosynthesis monooxygenase; Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the conversion of (4S)-4-hydroxy-5- phosphonooxypentane-2,3-dione (P-DPD) to 3-hydroxy-5- phosphonooxypentane-2,4-dione (P-HPD); Belongs to the LsrG family. | 0.921 |
| LsrF | pfkA | HMPREF0758_3362 | HMPREF0758_1183 | Deoxyribose-phosphate aldolase; COG: COG1830; Pfam: PF01791; InterPro: IPR013785. | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. | 0.914 |
| LsrF | pfkB | HMPREF0758_3362 | HMPREF0758_2889 | Deoxyribose-phosphate aldolase; COG: COG1830; Pfam: PF01791; InterPro: IPR013785. | 1-phosphofructokinase; COG: COG1105; Pfam: PF00294; InterPro: IPR011611; Belongs to the carbohydrate kinase PfkB family. | 0.917 |
| LsrF | tal | HMPREF0758_3362 | HMPREF0758_0585 | Deoxyribose-phosphate aldolase; COG: COG1830; Pfam: PF01791; InterPro: IPR013785. | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. | 0.916 |
| LsrF | tal-2 | HMPREF0758_3362 | HMPREF0758_2628 | Deoxyribose-phosphate aldolase; COG: COG1830; Pfam: PF01791; InterPro: IPR013785. | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. | 0.916 |
| LsrF | tpiA | HMPREF0758_3362 | HMPREF0758_1181 | Deoxyribose-phosphate aldolase; COG: COG1830; Pfam: PF01791; InterPro: IPR013785. | Triose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. | 0.923 |
| PfkA_2 | LsrF | HMPREF0758_3845 | HMPREF0758_3362 | Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. | Deoxyribose-phosphate aldolase; COG: COG1830; Pfam: PF01791; InterPro: IPR013785. | 0.914 |
| PfkA_2 | fbaA | HMPREF0758_3845 | HMPREF0758_2200 | Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. | Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. | 0.938 |
| PfkA_2 | fbp | HMPREF0758_3845 | HMPREF0758_0830 | Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. | Fructose-1,6-bisphosphatase; COG: COG0158; Pfam: PF00316; InterPro: IPR000146; Belongs to the FBPase class 1 family. | 0.921 |
| PfkA_2 | gap | HMPREF0758_3845 | HMPREF0758_3492 | Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. | Glyceraldehyde-3-phosphate dehydrogenase, type I; COG: COG0057; Pfam: PF00044,PF02800; InterPro: IPR000173; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. | 0.576 |
| PfkA_2 | pfkA | HMPREF0758_3845 | HMPREF0758_1183 | Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. | 0.925 |
| PfkA_2 | pfkB | HMPREF0758_3845 | HMPREF0758_2889 | Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. | 1-phosphofructokinase; COG: COG1105; Pfam: PF00294; InterPro: IPR011611; Belongs to the carbohydrate kinase PfkB family. | 0.929 |
| PfkA_2 | tal | HMPREF0758_3845 | HMPREF0758_0585 | Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. | 0.911 |
| PfkA_2 | tal-2 | HMPREF0758_3845 | HMPREF0758_2628 | Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. | 0.911 |
| PfkA_2 | tpiA | HMPREF0758_3845 | HMPREF0758_1181 | Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. | Triose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. | 0.775 |
| fbaA | LsrF | HMPREF0758_2200 | HMPREF0758_3362 | Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. | Deoxyribose-phosphate aldolase; COG: COG1830; Pfam: PF01791; InterPro: IPR013785. | 0.912 |