| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EFE94662.1 | TonB | HMPREF0758_3533 | HMPREF0758_3534 | Hypothetical protein; COG: COG1636; Pfam: PF02677; InterPro: IPR003828. | TonB-dependent receptor; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family. | 0.425 |
| EFE94662.1 | YciI | HMPREF0758_3533 | HMPREF0758_3532 | Hypothetical protein; COG: COG1636; Pfam: PF02677; InterPro: IPR003828. | Hypothetical protein; COG: COG2350; Pfam: PF03795; InterPro: IPR005545. | 0.444 |
| EFE94662.1 | metH | HMPREF0758_3533 | HMPREF0758_1689 | Hypothetical protein; COG: COG1636; Pfam: PF02677; InterPro: IPR003828. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.408 |
| EFE94662.1 | nrdG | HMPREF0758_3533 | HMPREF0758_0460 | Hypothetical protein; COG: COG1636; Pfam: PF02677; InterPro: IPR003828. | Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.413 |
| EFE94662.1 | queA | HMPREF0758_3533 | HMPREF0758_0234 | Hypothetical protein; COG: COG1636; Pfam: PF02677; InterPro: IPR003828. | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | 0.751 |
| EFE94662.1 | queF | HMPREF0758_3533 | HMPREF0758_1989 | Hypothetical protein; COG: COG1636; Pfam: PF02677; InterPro: IPR003828. | Queuine synthase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.411 |
| EFE94662.1 | queF-2 | HMPREF0758_3533 | HMPREF0758_2319 | Hypothetical protein; COG: COG1636; Pfam: PF02677; InterPro: IPR003828. | Queuine synthase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.411 |
| EFE94662.1 | rnhB | HMPREF0758_3533 | HMPREF0758_2345 | Hypothetical protein; COG: COG1636; Pfam: PF02677; InterPro: IPR003828. | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.835 |
| TonB | EFE94662.1 | HMPREF0758_3534 | HMPREF0758_3533 | TonB-dependent receptor; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family. | Hypothetical protein; COG: COG1636; Pfam: PF02677; InterPro: IPR003828. | 0.425 |
| YciI | EFE94662.1 | HMPREF0758_3532 | HMPREF0758_3533 | Hypothetical protein; COG: COG2350; Pfam: PF03795; InterPro: IPR005545. | Hypothetical protein; COG: COG1636; Pfam: PF02677; InterPro: IPR003828. | 0.444 |
| metH | EFE94662.1 | HMPREF0758_1689 | HMPREF0758_3533 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Hypothetical protein; COG: COG1636; Pfam: PF02677; InterPro: IPR003828. | 0.408 |
| metH | queA | HMPREF0758_1689 | HMPREF0758_0234 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | 0.400 |
| nrdG | EFE94662.1 | HMPREF0758_0460 | HMPREF0758_3533 | Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | Hypothetical protein; COG: COG1636; Pfam: PF02677; InterPro: IPR003828. | 0.413 |
| nrdG | queF | HMPREF0758_0460 | HMPREF0758_1989 | Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | Queuine synthase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.767 |
| nrdG | queF-2 | HMPREF0758_0460 | HMPREF0758_2319 | Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | Queuine synthase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.767 |
| queA | EFE94662.1 | HMPREF0758_0234 | HMPREF0758_3533 | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | Hypothetical protein; COG: COG1636; Pfam: PF02677; InterPro: IPR003828. | 0.751 |
| queA | metH | HMPREF0758_0234 | HMPREF0758_1689 | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.400 |
| queA | queF | HMPREF0758_0234 | HMPREF0758_1989 | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | Queuine synthase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.547 |
| queA | queF-2 | HMPREF0758_0234 | HMPREF0758_2319 | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | Queuine synthase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.546 |
| queF | EFE94662.1 | HMPREF0758_1989 | HMPREF0758_3533 | Queuine synthase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | Hypothetical protein; COG: COG1636; Pfam: PF02677; InterPro: IPR003828. | 0.411 |