| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EFE94526.1 | LuxA_3 | HMPREF0758_3760 | HMPREF0758_3758 | Permease, cytosine/purine, uracil, thiamine, allantoin family; COG: COG1457; Pfam: PF02133; InterPro: IPR001248; Belongs to the purine-cytosine permease (2.A.39) family. | Luciferase-like monooxygenase; COG: COG2141; Pfam: PF00296; InterPro: IPR011251. | 0.466 |
| EFE94526.1 | carA | HMPREF0758_3760 | HMPREF0758_0566 | Permease, cytosine/purine, uracil, thiamine, allantoin family; COG: COG1457; Pfam: PF02133; InterPro: IPR001248; Belongs to the purine-cytosine permease (2.A.39) family. | Carbamoyl-phosphate synthase, small subunit; COG: COG0505; Pfam: PF00988,PF00117; InterPro: IPR006274; Belongs to the CarA family. | 0.511 |
| EFE94526.1 | carB | HMPREF0758_3760 | HMPREF0758_0565 | Permease, cytosine/purine, uracil, thiamine, allantoin family; COG: COG1457; Pfam: PF02133; InterPro: IPR001248; Belongs to the purine-cytosine permease (2.A.39) family. | Carbamoyl-phosphate synthase, large subunit; COG: COG0458; Pfam: PF00289,PF02786,PF02787,PF02142; InterPro: IPR006275; Belongs to the CarB family. | 0.518 |
| EFE94526.1 | hutG | HMPREF0758_3760 | HMPREF0758_4033 | Permease, cytosine/purine, uracil, thiamine, allantoin family; COG: COG1457; Pfam: PF02133; InterPro: IPR001248; Belongs to the purine-cytosine permease (2.A.39) family. | N-formylglutamate deformylase; COG: COG3741; Pfam: PF05013; InterPro: IPR010247. | 0.551 |
| EFE94526.1 | hutU | HMPREF0758_3760 | HMPREF0758_0462 | Permease, cytosine/purine, uracil, thiamine, allantoin family; COG: COG1457; Pfam: PF02133; InterPro: IPR001248; Belongs to the purine-cytosine permease (2.A.39) family. | Urocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. | 0.694 |
| EFE94526.1 | proX | HMPREF0758_3760 | HMPREF0758_0465 | Permease, cytosine/purine, uracil, thiamine, allantoin family; COG: COG1457; Pfam: PF02133; InterPro: IPR001248; Belongs to the purine-cytosine permease (2.A.39) family. | ABC transporter, substrate-binding protein, QAT family; COG: COG2113; Pfam: PF04069; InterPro: IPR007210. | 0.637 |
| EFE94526.1 | putA | HMPREF0758_3760 | HMPREF0758_3240 | Permease, cytosine/purine, uracil, thiamine, allantoin family; COG: COG1457; Pfam: PF02133; InterPro: IPR001248; Belongs to the purine-cytosine permease (2.A.39) family. | Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; Belongs to the aldehyde dehydrogenase family. In the N-terminal section; belongs to the proline dehydrogenase family. | 0.466 |
| EFE94526.1 | pyrB | HMPREF0758_3760 | HMPREF0758_0752 | Permease, cytosine/purine, uracil, thiamine, allantoin family; COG: COG1457; Pfam: PF02133; InterPro: IPR001248; Belongs to the purine-cytosine permease (2.A.39) family. | Aspartate carbamoyltransferase; COG: COG0540; Pfam: PF02729,PF00185; InterPro: IPR002082; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.540 |
| EFE94526.1 | pyrC | HMPREF0758_3760 | HMPREF0758_4197 | Permease, cytosine/purine, uracil, thiamine, allantoin family; COG: COG1457; Pfam: PF02133; InterPro: IPR001248; Belongs to the purine-cytosine permease (2.A.39) family. | Dihydroorotase, homodimeric type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. | 0.518 |
| EFE94526.1 | pyrI | HMPREF0758_3760 | HMPREF0758_0753 | Permease, cytosine/purine, uracil, thiamine, allantoin family; COG: COG1457; Pfam: PF02133; InterPro: IPR001248; Belongs to the purine-cytosine permease (2.A.39) family. | Aspartate carbamoyltransferase, regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. | 0.539 |
| LuxA_3 | EFE94526.1 | HMPREF0758_3758 | HMPREF0758_3760 | Luciferase-like monooxygenase; COG: COG2141; Pfam: PF00296; InterPro: IPR011251. | Permease, cytosine/purine, uracil, thiamine, allantoin family; COG: COG1457; Pfam: PF02133; InterPro: IPR001248; Belongs to the purine-cytosine permease (2.A.39) family. | 0.466 |
| carA | EFE94526.1 | HMPREF0758_0566 | HMPREF0758_3760 | Carbamoyl-phosphate synthase, small subunit; COG: COG0505; Pfam: PF00988,PF00117; InterPro: IPR006274; Belongs to the CarA family. | Permease, cytosine/purine, uracil, thiamine, allantoin family; COG: COG1457; Pfam: PF02133; InterPro: IPR001248; Belongs to the purine-cytosine permease (2.A.39) family. | 0.511 |
| carA | carB | HMPREF0758_0566 | HMPREF0758_0565 | Carbamoyl-phosphate synthase, small subunit; COG: COG0505; Pfam: PF00988,PF00117; InterPro: IPR006274; Belongs to the CarA family. | Carbamoyl-phosphate synthase, large subunit; COG: COG0458; Pfam: PF00289,PF02786,PF02787,PF02142; InterPro: IPR006275; Belongs to the CarB family. | 0.999 |
| carA | pyrB | HMPREF0758_0566 | HMPREF0758_0752 | Carbamoyl-phosphate synthase, small subunit; COG: COG0505; Pfam: PF00988,PF00117; InterPro: IPR006274; Belongs to the CarA family. | Aspartate carbamoyltransferase; COG: COG0540; Pfam: PF02729,PF00185; InterPro: IPR002082; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.999 |
| carA | pyrC | HMPREF0758_0566 | HMPREF0758_4197 | Carbamoyl-phosphate synthase, small subunit; COG: COG0505; Pfam: PF00988,PF00117; InterPro: IPR006274; Belongs to the CarA family. | Dihydroorotase, homodimeric type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. | 0.619 |
| carA | pyrI | HMPREF0758_0566 | HMPREF0758_0753 | Carbamoyl-phosphate synthase, small subunit; COG: COG0505; Pfam: PF00988,PF00117; InterPro: IPR006274; Belongs to the CarA family. | Aspartate carbamoyltransferase, regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. | 0.959 |
| carB | EFE94526.1 | HMPREF0758_0565 | HMPREF0758_3760 | Carbamoyl-phosphate synthase, large subunit; COG: COG0458; Pfam: PF00289,PF02786,PF02787,PF02142; InterPro: IPR006275; Belongs to the CarB family. | Permease, cytosine/purine, uracil, thiamine, allantoin family; COG: COG1457; Pfam: PF02133; InterPro: IPR001248; Belongs to the purine-cytosine permease (2.A.39) family. | 0.518 |
| carB | carA | HMPREF0758_0565 | HMPREF0758_0566 | Carbamoyl-phosphate synthase, large subunit; COG: COG0458; Pfam: PF00289,PF02786,PF02787,PF02142; InterPro: IPR006275; Belongs to the CarB family. | Carbamoyl-phosphate synthase, small subunit; COG: COG0505; Pfam: PF00988,PF00117; InterPro: IPR006274; Belongs to the CarA family. | 0.999 |
| carB | pyrB | HMPREF0758_0565 | HMPREF0758_0752 | Carbamoyl-phosphate synthase, large subunit; COG: COG0458; Pfam: PF00289,PF02786,PF02787,PF02142; InterPro: IPR006275; Belongs to the CarB family. | Aspartate carbamoyltransferase; COG: COG0540; Pfam: PF02729,PF00185; InterPro: IPR002082; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.999 |
| carB | pyrC | HMPREF0758_0565 | HMPREF0758_4197 | Carbamoyl-phosphate synthase, large subunit; COG: COG0458; Pfam: PF00289,PF02786,PF02787,PF02142; InterPro: IPR006275; Belongs to the CarB family. | Dihydroorotase, homodimeric type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. | 0.664 |