| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| dinF | epd | HMPREF0758_1709 | HMPREF0758_2198 | MATE efflux family protein; COG: COG0534; Pfam: PF01554; InterPro: IPR002528. | D-erythrose-4-phosphate dehydrogenase; Catalyzes the NAD-dependent conversion of D-erythrose 4- phosphate to 4-phosphoerythronate. | 0.542 |
| dinF | gap | HMPREF0758_1709 | HMPREF0758_3492 | MATE efflux family protein; COG: COG0534; Pfam: PF01554; InterPro: IPR002528. | Glyceraldehyde-3-phosphate dehydrogenase, type I; COG: COG0057; Pfam: PF00044,PF02800; InterPro: IPR000173; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. | 0.542 |
| dinF | rpsA | HMPREF0758_1709 | HMPREF0758_4383 | MATE efflux family protein; COG: COG0534; Pfam: PF01554; InterPro: IPR002528. | Ribosomal protein S1; Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence. | 0.541 |
| dinF | sqs | HMPREF0758_1709 | HMPREF0758_3761 | MATE efflux family protein; COG: COG0534; Pfam: PF01554; InterPro: IPR002528. | Phytoene/squalene synthetase; Pfam: PF00494; InterPro: IPR008949. | 0.614 |
| epd | dinF | HMPREF0758_2198 | HMPREF0758_1709 | D-erythrose-4-phosphate dehydrogenase; Catalyzes the NAD-dependent conversion of D-erythrose 4- phosphate to 4-phosphoerythronate. | MATE efflux family protein; COG: COG0534; Pfam: PF01554; InterPro: IPR002528. | 0.542 |
| epd | nuoD | HMPREF0758_2198 | HMPREF0758_2794 | D-erythrose-4-phosphate dehydrogenase; Catalyzes the NAD-dependent conversion of D-erythrose 4- phosphate to 4-phosphoerythronate. | NADH dehydrogenase subunit D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the C-terminal section; belongs to the complex I 49 kDa subunit family. | 0.540 |
| epd | rpsA | HMPREF0758_2198 | HMPREF0758_4383 | D-erythrose-4-phosphate dehydrogenase; Catalyzes the NAD-dependent conversion of D-erythrose 4- phosphate to 4-phosphoerythronate. | Ribosomal protein S1; Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence. | 0.576 |
| epd | sqs | HMPREF0758_2198 | HMPREF0758_3761 | D-erythrose-4-phosphate dehydrogenase; Catalyzes the NAD-dependent conversion of D-erythrose 4- phosphate to 4-phosphoerythronate. | Phytoene/squalene synthetase; Pfam: PF00494; InterPro: IPR008949. | 0.693 |
| gap | dinF | HMPREF0758_3492 | HMPREF0758_1709 | Glyceraldehyde-3-phosphate dehydrogenase, type I; COG: COG0057; Pfam: PF00044,PF02800; InterPro: IPR000173; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. | MATE efflux family protein; COG: COG0534; Pfam: PF01554; InterPro: IPR002528. | 0.542 |
| gap | nuoD | HMPREF0758_3492 | HMPREF0758_2794 | Glyceraldehyde-3-phosphate dehydrogenase, type I; COG: COG0057; Pfam: PF00044,PF02800; InterPro: IPR000173; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. | NADH dehydrogenase subunit D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the C-terminal section; belongs to the complex I 49 kDa subunit family. | 0.540 |
| gap | rpsA | HMPREF0758_3492 | HMPREF0758_4383 | Glyceraldehyde-3-phosphate dehydrogenase, type I; COG: COG0057; Pfam: PF00044,PF02800; InterPro: IPR000173; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. | Ribosomal protein S1; Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence. | 0.576 |
| gap | sqs | HMPREF0758_3492 | HMPREF0758_3761 | Glyceraldehyde-3-phosphate dehydrogenase, type I; COG: COG0057; Pfam: PF00044,PF02800; InterPro: IPR000173; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. | Phytoene/squalene synthetase; Pfam: PF00494; InterPro: IPR008949. | 0.693 |
| ispA | ispB | HMPREF0758_0220 | HMPREF0758_0821 | Polyprenyl synthetase; COG: COG0142; Pfam: PF00348; InterPro: IPR008949; Belongs to the FPP/GGPP synthase family. | Polyprenyl synthetase; COG: COG0142; Pfam: PF00348; InterPro: IPR008949; Belongs to the FPP/GGPP synthase family. | 0.927 |
| ispA | sqs | HMPREF0758_0220 | HMPREF0758_3761 | Polyprenyl synthetase; COG: COG0142; Pfam: PF00348; InterPro: IPR008949; Belongs to the FPP/GGPP synthase family. | Phytoene/squalene synthetase; Pfam: PF00494; InterPro: IPR008949. | 0.927 |
| ispA | uppS | HMPREF0758_0220 | HMPREF0758_2336 | Polyprenyl synthetase; COG: COG0142; Pfam: PF00348; InterPro: IPR008949; Belongs to the FPP/GGPP synthase family. | Di-trans,poly-cis-decaprenylcistransferase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. | 0.971 |
| ispB | ispA | HMPREF0758_0821 | HMPREF0758_0220 | Polyprenyl synthetase; COG: COG0142; Pfam: PF00348; InterPro: IPR008949; Belongs to the FPP/GGPP synthase family. | Polyprenyl synthetase; COG: COG0142; Pfam: PF00348; InterPro: IPR008949; Belongs to the FPP/GGPP synthase family. | 0.927 |
| ispB | sqs | HMPREF0758_0821 | HMPREF0758_3761 | Polyprenyl synthetase; COG: COG0142; Pfam: PF00348; InterPro: IPR008949; Belongs to the FPP/GGPP synthase family. | Phytoene/squalene synthetase; Pfam: PF00494; InterPro: IPR008949. | 0.906 |
| ispB | uppS | HMPREF0758_0821 | HMPREF0758_2336 | Polyprenyl synthetase; COG: COG0142; Pfam: PF00348; InterPro: IPR008949; Belongs to the FPP/GGPP synthase family. | Di-trans,poly-cis-decaprenylcistransferase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. | 0.971 |
| nuoB | nuoD | HMPREF0758_2793 | HMPREF0758_2794 | NADH dehydrogenase subunit B; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. | NADH dehydrogenase subunit D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the C-terminal section; belongs to the complex I 49 kDa subunit family. | 0.999 |
| nuoB | nuoH | HMPREF0758_2793 | HMPREF0758_2798 | NADH dehydrogenase subunit B; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. | NUO8; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone. | 0.999 |