| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EFE94572.1 | EFE94574.1 | HMPREF0758_3806 | HMPREF0758_3808 | Hydrolase, alpha/beta domain protein; Pfam: PF00561; InterPro: IPR000073. | Isochorismatase family protein; Pfam: PF00857; InterPro: IPR000868. | 0.987 |
| EFE94572.1 | maiA | HMPREF0758_3806 | HMPREF0758_3807 | Hydrolase, alpha/beta domain protein; Pfam: PF00561; InterPro: IPR000073. | Asp/Glu/Hydantoin racemase; Catalyzes cis-trans isomerization of the C2-C3 double bond in maleate to yield fumarate. | 0.931 |
| EFE94572.1 | nahG | HMPREF0758_3806 | HMPREF0758_3805 | Hydrolase, alpha/beta domain protein; Pfam: PF00561; InterPro: IPR000073. | FAD binding domain protein; COG: COG0654; Pfam: PF01494. | 0.899 |
| EFE94574.1 | EFE94572.1 | HMPREF0758_3808 | HMPREF0758_3806 | Isochorismatase family protein; Pfam: PF00857; InterPro: IPR000868. | Hydrolase, alpha/beta domain protein; Pfam: PF00561; InterPro: IPR000073. | 0.987 |
| EFE94574.1 | maiA | HMPREF0758_3808 | HMPREF0758_3807 | Isochorismatase family protein; Pfam: PF00857; InterPro: IPR000868. | Asp/Glu/Hydantoin racemase; Catalyzes cis-trans isomerization of the C2-C3 double bond in maleate to yield fumarate. | 0.990 |
| EFE94574.1 | nahG | HMPREF0758_3808 | HMPREF0758_3805 | Isochorismatase family protein; Pfam: PF00857; InterPro: IPR000868. | FAD binding domain protein; COG: COG0654; Pfam: PF01494. | 0.839 |
| frdA | frdB | HMPREF0758_0879 | HMPREF0758_0880 | Fumarate reductase, flavoprotein subunit; COG: COG1053; Pfam: PF00890,PF02910; InterPro: IPR005884. | Succinate dehydrogenase and fumarate reductase iron-sulfur protein; COG: COG0479; Pfam: PF00111,PF00037; InterPro: IPR004489; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | 0.999 |
| frdA | frdC | HMPREF0758_0879 | HMPREF0758_0881 | Fumarate reductase, flavoprotein subunit; COG: COG1053; Pfam: PF00890,PF02910; InterPro: IPR005884. | Fumarate reductase subunit C; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. | 0.997 |
| frdA | frdD | HMPREF0758_0879 | HMPREF0758_0882 | Fumarate reductase, flavoprotein subunit; COG: COG1053; Pfam: PF00890,PF02910; InterPro: IPR005884. | Fumarate reductase 13 kDa hydrophobic protein; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. | 0.996 |
| frdA | maiA | HMPREF0758_0879 | HMPREF0758_3807 | Fumarate reductase, flavoprotein subunit; COG: COG1053; Pfam: PF00890,PF02910; InterPro: IPR005884. | Asp/Glu/Hydantoin racemase; Catalyzes cis-trans isomerization of the C2-C3 double bond in maleate to yield fumarate. | 0.902 |
| frdA | sdhA | HMPREF0758_0879 | HMPREF0758_4845 | Fumarate reductase, flavoprotein subunit; COG: COG1053; Pfam: PF00890,PF02910; InterPro: IPR005884. | Succinate dehydrogenase, flavoprotein subunit; COG: COG1053; Pfam: PF00890,PF02910; InterPro: IPR011281; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | 0.911 |
| frdA | sdhB | HMPREF0758_0879 | HMPREF0758_4844 | Fumarate reductase, flavoprotein subunit; COG: COG1053; Pfam: PF00890,PF02910; InterPro: IPR005884. | Succinate dehydrogenase iron-sulfur subunit; COG: COG0479; Pfam: PF00111; InterPro: IPR004489; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | 0.998 |
| frdA | sdhD | HMPREF0758_0879 | HMPREF0758_4846 | Fumarate reductase, flavoprotein subunit; COG: COG1053; Pfam: PF00890,PF02910; InterPro: IPR005884. | Succinate dehydrogenase, hydrophobic membrane anchor protein; Membrane-anchoring subunit of succinate dehydrogenase (SDH). | 0.984 |
| frdB | frdA | HMPREF0758_0880 | HMPREF0758_0879 | Succinate dehydrogenase and fumarate reductase iron-sulfur protein; COG: COG0479; Pfam: PF00111,PF00037; InterPro: IPR004489; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | Fumarate reductase, flavoprotein subunit; COG: COG1053; Pfam: PF00890,PF02910; InterPro: IPR005884. | 0.999 |
| frdB | frdC | HMPREF0758_0880 | HMPREF0758_0881 | Succinate dehydrogenase and fumarate reductase iron-sulfur protein; COG: COG0479; Pfam: PF00111,PF00037; InterPro: IPR004489; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | Fumarate reductase subunit C; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. | 0.999 |
| frdB | frdD | HMPREF0758_0880 | HMPREF0758_0882 | Succinate dehydrogenase and fumarate reductase iron-sulfur protein; COG: COG0479; Pfam: PF00111,PF00037; InterPro: IPR004489; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | Fumarate reductase 13 kDa hydrophobic protein; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. | 0.999 |
| frdB | maiA | HMPREF0758_0880 | HMPREF0758_3807 | Succinate dehydrogenase and fumarate reductase iron-sulfur protein; COG: COG0479; Pfam: PF00111,PF00037; InterPro: IPR004489; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | Asp/Glu/Hydantoin racemase; Catalyzes cis-trans isomerization of the C2-C3 double bond in maleate to yield fumarate. | 0.900 |
| frdB | sdhA | HMPREF0758_0880 | HMPREF0758_4845 | Succinate dehydrogenase and fumarate reductase iron-sulfur protein; COG: COG0479; Pfam: PF00111,PF00037; InterPro: IPR004489; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | Succinate dehydrogenase, flavoprotein subunit; COG: COG1053; Pfam: PF00890,PF02910; InterPro: IPR011281; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | 0.998 |
| frdB | sdhB | HMPREF0758_0880 | HMPREF0758_4844 | Succinate dehydrogenase and fumarate reductase iron-sulfur protein; COG: COG0479; Pfam: PF00111,PF00037; InterPro: IPR004489; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | Succinate dehydrogenase iron-sulfur subunit; COG: COG0479; Pfam: PF00111; InterPro: IPR004489; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | 0.914 |
| frdB | sdhD | HMPREF0758_0880 | HMPREF0758_4846 | Succinate dehydrogenase and fumarate reductase iron-sulfur protein; COG: COG0479; Pfam: PF00111,PF00037; InterPro: IPR004489; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | Succinate dehydrogenase, hydrophobic membrane anchor protein; Membrane-anchoring subunit of succinate dehydrogenase (SDH). | 0.989 |