| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EFE94380.1 | hemR | HMPREF0758_3954 | HMPREF0758_3955 | Hypothetical protein. | TonB-dependent heme/hemoglobin receptor family protein; COG: COG1629; Pfam: PF07715,PF00593; InterPro: IPR011276. | 0.611 |
| TonB | hemR | HMPREF0758_3534 | HMPREF0758_3955 | TonB-dependent receptor; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family. | TonB-dependent heme/hemoglobin receptor family protein; COG: COG1629; Pfam: PF07715,PF00593; InterPro: IPR011276. | 0.628 |
| btuF | entB | HMPREF0758_0489 | HMPREF0758_2684 | Periplasmic binding protein; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC. | Isochorismatase; COG: COG1535; Pfam: PF00857,PF00550; InterPro: IPR000868. | 0.440 |
| btuF | hemR | HMPREF0758_0489 | HMPREF0758_3955 | Periplasmic binding protein; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC. | TonB-dependent heme/hemoglobin receptor family protein; COG: COG1629; Pfam: PF07715,PF00593; InterPro: IPR011276. | 0.512 |
| btuF | hmuS | HMPREF0758_0489 | HMPREF0758_3956 | Periplasmic binding protein; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC. | Putative hemin transport protein HmuS; COG: COG3720; Pfam: PF05171; InterPro: IPR007845. | 0.424 |
| btuF | hmuU | HMPREF0758_0489 | HMPREF0758_3958 | Periplasmic binding protein; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC. | Iron chelate uptake ABC transporter, FeCT family, permease protein; COG: COG0609; Pfam: PF01032; InterPro: IPR000522; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. | 0.871 |
| btuF | hmuV | HMPREF0758_0489 | HMPREF0758_3959 | Periplasmic binding protein; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC. | Hemin import ATP-binding protein HmuV; Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system. | 0.689 |
| entB | btuF | HMPREF0758_2684 | HMPREF0758_0489 | Isochorismatase; COG: COG1535; Pfam: PF00857,PF00550; InterPro: IPR000868. | Periplasmic binding protein; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC. | 0.440 |
| entB | entF | HMPREF0758_2684 | HMPREF0758_2676 | Isochorismatase; COG: COG1535; Pfam: PF00857,PF00550; InterPro: IPR000868. | AMP-binding enzyme; COG: COG1020; Pfam: PF00668,PF00501,PF00550,PF00975; InterPro: IPR010071. | 0.999 |
| entB | hemR | HMPREF0758_2684 | HMPREF0758_3955 | Isochorismatase; COG: COG1535; Pfam: PF00857,PF00550; InterPro: IPR000868. | TonB-dependent heme/hemoglobin receptor family protein; COG: COG1629; Pfam: PF07715,PF00593; InterPro: IPR011276. | 0.701 |
| entB | hmuU | HMPREF0758_2684 | HMPREF0758_3958 | Isochorismatase; COG: COG1535; Pfam: PF00857,PF00550; InterPro: IPR000868. | Iron chelate uptake ABC transporter, FeCT family, permease protein; COG: COG0609; Pfam: PF01032; InterPro: IPR000522; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. | 0.415 |
| entF | entB | HMPREF0758_2676 | HMPREF0758_2684 | AMP-binding enzyme; COG: COG1020; Pfam: PF00668,PF00501,PF00550,PF00975; InterPro: IPR010071. | Isochorismatase; COG: COG1535; Pfam: PF00857,PF00550; InterPro: IPR000868. | 0.999 |
| entF | hemR | HMPREF0758_2676 | HMPREF0758_3955 | AMP-binding enzyme; COG: COG1020; Pfam: PF00668,PF00501,PF00550,PF00975; InterPro: IPR010071. | TonB-dependent heme/hemoglobin receptor family protein; COG: COG1629; Pfam: PF07715,PF00593; InterPro: IPR011276. | 0.673 |
| hemR | EFE94380.1 | HMPREF0758_3955 | HMPREF0758_3954 | TonB-dependent heme/hemoglobin receptor family protein; COG: COG1629; Pfam: PF07715,PF00593; InterPro: IPR011276. | Hypothetical protein. | 0.611 |
| hemR | TonB | HMPREF0758_3955 | HMPREF0758_3534 | TonB-dependent heme/hemoglobin receptor family protein; COG: COG1629; Pfam: PF07715,PF00593; InterPro: IPR011276. | TonB-dependent receptor; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family. | 0.628 |
| hemR | btuF | HMPREF0758_3955 | HMPREF0758_0489 | TonB-dependent heme/hemoglobin receptor family protein; COG: COG1629; Pfam: PF07715,PF00593; InterPro: IPR011276. | Periplasmic binding protein; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC. | 0.512 |
| hemR | entB | HMPREF0758_3955 | HMPREF0758_2684 | TonB-dependent heme/hemoglobin receptor family protein; COG: COG1629; Pfam: PF07715,PF00593; InterPro: IPR011276. | Isochorismatase; COG: COG1535; Pfam: PF00857,PF00550; InterPro: IPR000868. | 0.701 |
| hemR | entF | HMPREF0758_3955 | HMPREF0758_2676 | TonB-dependent heme/hemoglobin receptor family protein; COG: COG1629; Pfam: PF07715,PF00593; InterPro: IPR011276. | AMP-binding enzyme; COG: COG1020; Pfam: PF00668,PF00501,PF00550,PF00975; InterPro: IPR010071. | 0.673 |
| hemR | hmuS | HMPREF0758_3955 | HMPREF0758_3956 | TonB-dependent heme/hemoglobin receptor family protein; COG: COG1629; Pfam: PF07715,PF00593; InterPro: IPR011276. | Putative hemin transport protein HmuS; COG: COG3720; Pfam: PF05171; InterPro: IPR007845. | 0.734 |
| hemR | hmuT | HMPREF0758_3955 | HMPREF0758_3957 | TonB-dependent heme/hemoglobin receptor family protein; COG: COG1629; Pfam: PF07715,PF00593; InterPro: IPR011276. | Hemin-binding periplasmic protein HmuT; COG: COG4558; Pfam: PF01497; InterPro: IPR002491. | 0.710 |