| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| aroC | entC | HMPREF0758_2727 | HMPREF0758_2682 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Isochorismate synthase; COG: COG1169; Pfam: PF00425; InterPro: IPR004561. | 0.893 |
| aroC | menF | HMPREF0758_2727 | HMPREF0758_2815 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Isochorismate synthase; Catalyzes the conversion of chorismate to isochorismate. | 0.929 |
| aroC | pabB | HMPREF0758_2727 | HMPREF0758_3332 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Aminodeoxychorismate synthase, component I; COG: COG0147; Pfam: PF04715,PF00425; InterPro: IPR005801. | 0.944 |
| aroC | pheA | HMPREF0758_2727 | HMPREF0758_0402 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Chorismate mutase; COG: COG0077; Pfam: PF01817,PF00800; InterPro: IPR001086. | 0.983 |
| aroC | pheA2 | HMPREF0758_2727 | HMPREF0758_4035 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Putative chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate. | 0.958 |
| aroC | trpE | HMPREF0758_2727 | HMPREF0758_3547 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Anthranilate synthase component I; COG: COG0147; Pfam: PF04715,PF00425; InterPro: IPR005801. | 0.966 |
| aroC | trpG2 | HMPREF0758_2727 | HMPREF0758_3546 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Glutamine amidotransferase, class I; COG: COG0512; Pfam: PF00117; InterPro: IPR006221. | 0.987 |
| aroC | tyrA | HMPREF0758_2727 | HMPREF0758_0403 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Chorismate mutase; COG: COG0287; Pfam: PF01817,PF02153; InterPro: IPR003099. | 0.998 |
| entC | aroC | HMPREF0758_2682 | HMPREF0758_2727 | Isochorismate synthase; COG: COG1169; Pfam: PF00425; InterPro: IPR004561. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.893 |
| entC | menF | HMPREF0758_2682 | HMPREF0758_2815 | Isochorismate synthase; COG: COG1169; Pfam: PF00425; InterPro: IPR004561. | Isochorismate synthase; Catalyzes the conversion of chorismate to isochorismate. | 0.927 |
| entC | pheA | HMPREF0758_2682 | HMPREF0758_0402 | Isochorismate synthase; COG: COG1169; Pfam: PF00425; InterPro: IPR004561. | Chorismate mutase; COG: COG0077; Pfam: PF01817,PF00800; InterPro: IPR001086. | 0.911 |
| entC | pheA2 | HMPREF0758_2682 | HMPREF0758_4035 | Isochorismate synthase; COG: COG1169; Pfam: PF00425; InterPro: IPR004561. | Putative chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate. | 0.888 |
| entC | trpE | HMPREF0758_2682 | HMPREF0758_3547 | Isochorismate synthase; COG: COG1169; Pfam: PF00425; InterPro: IPR004561. | Anthranilate synthase component I; COG: COG0147; Pfam: PF04715,PF00425; InterPro: IPR005801. | 0.869 |
| entC | trpG2 | HMPREF0758_2682 | HMPREF0758_3546 | Isochorismate synthase; COG: COG1169; Pfam: PF00425; InterPro: IPR004561. | Glutamine amidotransferase, class I; COG: COG0512; Pfam: PF00117; InterPro: IPR006221. | 0.949 |
| entC | tyrA | HMPREF0758_2682 | HMPREF0758_0403 | Isochorismate synthase; COG: COG1169; Pfam: PF00425; InterPro: IPR004561. | Chorismate mutase; COG: COG0287; Pfam: PF01817,PF02153; InterPro: IPR003099. | 0.900 |
| entC | tyrB | HMPREF0758_2682 | HMPREF0758_1780 | Isochorismate synthase; COG: COG1169; Pfam: PF00425; InterPro: IPR004561. | Aminotransferase, class I/II; COG: COG1448; Pfam: PF00155; InterPro: IPR000796. | 0.812 |
| menF | aroC | HMPREF0758_2815 | HMPREF0758_2727 | Isochorismate synthase; Catalyzes the conversion of chorismate to isochorismate. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.929 |
| menF | entC | HMPREF0758_2815 | HMPREF0758_2682 | Isochorismate synthase; Catalyzes the conversion of chorismate to isochorismate. | Isochorismate synthase; COG: COG1169; Pfam: PF00425; InterPro: IPR004561. | 0.927 |
| menF | pheA | HMPREF0758_2815 | HMPREF0758_0402 | Isochorismate synthase; Catalyzes the conversion of chorismate to isochorismate. | Chorismate mutase; COG: COG0077; Pfam: PF01817,PF00800; InterPro: IPR001086. | 0.916 |
| menF | pheA2 | HMPREF0758_2815 | HMPREF0758_4035 | Isochorismate synthase; Catalyzes the conversion of chorismate to isochorismate. | Putative chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate. | 0.850 |