| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| YhcB | ftsN | HMPREF0758_1869 | HMPREF0758_1167 | Hypothetical protein; COG: COG3105; Pfam: PF06295; InterPro: IPR009386. | Cell division protein FtsN; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. | 0.687 |
| YhcB | holD | HMPREF0758_1869 | HMPREF0758_0633 | Hypothetical protein; COG: COG3105; Pfam: PF06295; InterPro: IPR009386. | DNA polymerase III subunit psi; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown. | 0.765 |
| YhcB | mukF | HMPREF0758_1869 | HMPREF0758_4369 | Hypothetical protein; COG: COG3105; Pfam: PF06295; InterPro: IPR009386. | KicB killing factor; Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity. | 0.674 |
| YhcB | ompN | HMPREF0758_1869 | HMPREF0758_2837 | Hypothetical protein; COG: COG3105; Pfam: PF06295; InterPro: IPR009386. | Gram-negative porin; COG: COG3203; Pfam: PF00267; InterPro: IPR001702; Belongs to the Gram-negative porin family. | 0.753 |
| YhcB | ompN-2 | HMPREF0758_1869 | HMPREF0758_4362 | Hypothetical protein; COG: COG3105; Pfam: PF06295; InterPro: IPR009386. | Outer membrane protein N; COG: COG3203; Pfam: PF00267; InterPro: IPR001702; Belongs to the Gram-negative porin family. | 0.766 |
| YhcB | ompN4 | HMPREF0758_1869 | HMPREF0758_4677 | Hypothetical protein; COG: COG3105; Pfam: PF06295; InterPro: IPR009386. | Gram-negative porin; COG: COG3203; Pfam: PF00267; InterPro: IPR001702; Belongs to the Gram-negative porin family. | 0.765 |
| YhcB | phoE | HMPREF0758_1869 | HMPREF0758_3296 | Hypothetical protein; COG: COG3105; Pfam: PF06295; InterPro: IPR009386. | Outer membrane pore protein E; COG: COG3203; Pfam: PF00267; InterPro: IPR001702. | 0.768 |
| YhcB | uspA2 | HMPREF0758_1869 | HMPREF0758_4048 | Hypothetical protein; COG: COG3105; Pfam: PF06295; InterPro: IPR009386. | Universal stress family protein; COG: COG0589; Pfam: PF00582; InterPro: IPR014729. | 0.729 |
| YhcB | zapB | HMPREF0758_1869 | HMPREF0758_1172 | Hypothetical protein; COG: COG3105; Pfam: PF06295; InterPro: IPR009386. | Hypothetical protein; Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA. | 0.770 |
| ftsN | YhcB | HMPREF0758_1167 | HMPREF0758_1869 | Cell division protein FtsN; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. | Hypothetical protein; COG: COG3105; Pfam: PF06295; InterPro: IPR009386. | 0.687 |
| ftsN | holD | HMPREF0758_1167 | HMPREF0758_0633 | Cell division protein FtsN; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. | DNA polymerase III subunit psi; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown. | 0.777 |
| ftsN | mukF | HMPREF0758_1167 | HMPREF0758_4369 | Cell division protein FtsN; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. | KicB killing factor; Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity. | 0.584 |
| ftsN | ompN | HMPREF0758_1167 | HMPREF0758_2837 | Cell division protein FtsN; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. | Gram-negative porin; COG: COG3203; Pfam: PF00267; InterPro: IPR001702; Belongs to the Gram-negative porin family. | 0.728 |
| ftsN | ompN-2 | HMPREF0758_1167 | HMPREF0758_4362 | Cell division protein FtsN; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. | Outer membrane protein N; COG: COG3203; Pfam: PF00267; InterPro: IPR001702; Belongs to the Gram-negative porin family. | 0.724 |
| ftsN | ompN4 | HMPREF0758_1167 | HMPREF0758_4677 | Cell division protein FtsN; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. | Gram-negative porin; COG: COG3203; Pfam: PF00267; InterPro: IPR001702; Belongs to the Gram-negative porin family. | 0.741 |
| ftsN | phoE | HMPREF0758_1167 | HMPREF0758_3296 | Cell division protein FtsN; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. | Outer membrane pore protein E; COG: COG3203; Pfam: PF00267; InterPro: IPR001702. | 0.737 |
| ftsN | uspA2 | HMPREF0758_1167 | HMPREF0758_4048 | Cell division protein FtsN; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. | Universal stress family protein; COG: COG0589; Pfam: PF00582; InterPro: IPR014729. | 0.648 |
| ftsN | zapB | HMPREF0758_1167 | HMPREF0758_1172 | Cell division protein FtsN; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. | Hypothetical protein; Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA. | 0.762 |
| holD | YhcB | HMPREF0758_0633 | HMPREF0758_1869 | DNA polymerase III subunit psi; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown. | Hypothetical protein; COG: COG3105; Pfam: PF06295; InterPro: IPR009386. | 0.765 |
| holD | ftsN | HMPREF0758_0633 | HMPREF0758_1167 | DNA polymerase III subunit psi; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown. | Cell division protein FtsN; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. | 0.777 |