| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EFE94043.1 | icd | HMPREF0758_4138 | HMPREF0758_4136 | Hypothetical protein; COG: COG4461. | Isocitrate dehydrogenase, NADP-dependent; COG: COG0538; Pfam: PF00180; InterPro: IPR004439. | 0.499 |
| EFE94043.1 | nudJ | HMPREF0758_4138 | HMPREF0758_4139 | Hypothetical protein; COG: COG4461. | Phosphatase NudJ; COG: COG0494; Pfam: PF00293; InterPro: IPR000086; Belongs to the Nudix hydrolase family. NudJ subfamily. | 0.780 |
| EFE94043.1 | rluE | HMPREF0758_4138 | HMPREF0758_4137 | Hypothetical protein; COG: COG4461. | Ribosomal large subunit pseudouridine synthase E; COG: COG1187; Pfam: PF00849; InterPro: IPR000748; Belongs to the pseudouridine synthase RsuA family. | 0.732 |
| EFE94043.1 | trmU | HMPREF0758_4138 | HMPREF0758_4140 | Hypothetical protein; COG: COG4461. | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln), leading to the formation of s(2)U34, the first step of tRNA-mnm(5)s(2)U34 synthesis. Sulfur is provided by IscS, via a sulfur-relay system. Binds ATP and its substrate tRNAs; Belongs to the MnmA/TRMU family. | 0.534 |
| cmk | der | HMPREF0758_4384 | HMPREF0758_2505 | Cytidylate kinase; COG: COG0283; Pfam: PF02224; InterPro: IPR003136. | Ribosome biogenesis GTPase Der; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | 0.986 |
| cmk | rluB | HMPREF0758_4384 | HMPREF0758_3552 | Cytidylate kinase; COG: COG0283; Pfam: PF02224; InterPro: IPR003136. | Pseudouridine synthase B, ribosomal large subunit; COG: COG1187; Pfam: PF01479,PF00849; InterPro: IPR000748; Belongs to the pseudouridine synthase RsuA family. | 0.748 |
| cmk | rluE | HMPREF0758_4384 | HMPREF0758_4137 | Cytidylate kinase; COG: COG0283; Pfam: PF02224; InterPro: IPR003136. | Ribosomal large subunit pseudouridine synthase E; COG: COG1187; Pfam: PF00849; InterPro: IPR000748; Belongs to the pseudouridine synthase RsuA family. | 0.637 |
| der | cmk | HMPREF0758_2505 | HMPREF0758_4384 | Ribosome biogenesis GTPase Der; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | Cytidylate kinase; COG: COG0283; Pfam: PF02224; InterPro: IPR003136. | 0.986 |
| der | rluB | HMPREF0758_2505 | HMPREF0758_3552 | Ribosome biogenesis GTPase Der; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | Pseudouridine synthase B, ribosomal large subunit; COG: COG1187; Pfam: PF01479,PF00849; InterPro: IPR000748; Belongs to the pseudouridine synthase RsuA family. | 0.838 |
| der | rluD | HMPREF0758_2505 | HMPREF0758_0398 | Ribosome biogenesis GTPase Der; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | Pseudouridine synthase, RluA family; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. | 0.552 |
| der | rluE | HMPREF0758_2505 | HMPREF0758_4137 | Ribosome biogenesis GTPase Der; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | Ribosomal large subunit pseudouridine synthase E; COG: COG1187; Pfam: PF00849; InterPro: IPR000748; Belongs to the pseudouridine synthase RsuA family. | 0.646 |
| icd | EFE94043.1 | HMPREF0758_4136 | HMPREF0758_4138 | Isocitrate dehydrogenase, NADP-dependent; COG: COG0538; Pfam: PF00180; InterPro: IPR004439. | Hypothetical protein; COG: COG4461. | 0.499 |
| icd | nudJ | HMPREF0758_4136 | HMPREF0758_4139 | Isocitrate dehydrogenase, NADP-dependent; COG: COG0538; Pfam: PF00180; InterPro: IPR004439. | Phosphatase NudJ; COG: COG0494; Pfam: PF00293; InterPro: IPR000086; Belongs to the Nudix hydrolase family. NudJ subfamily. | 0.518 |
| icd | rluE | HMPREF0758_4136 | HMPREF0758_4137 | Isocitrate dehydrogenase, NADP-dependent; COG: COG0538; Pfam: PF00180; InterPro: IPR004439. | Ribosomal large subunit pseudouridine synthase E; COG: COG1187; Pfam: PF00849; InterPro: IPR000748; Belongs to the pseudouridine synthase RsuA family. | 0.561 |
| nudJ | EFE94043.1 | HMPREF0758_4139 | HMPREF0758_4138 | Phosphatase NudJ; COG: COG0494; Pfam: PF00293; InterPro: IPR000086; Belongs to the Nudix hydrolase family. NudJ subfamily. | Hypothetical protein; COG: COG4461. | 0.780 |
| nudJ | icd | HMPREF0758_4139 | HMPREF0758_4136 | Phosphatase NudJ; COG: COG0494; Pfam: PF00293; InterPro: IPR000086; Belongs to the Nudix hydrolase family. NudJ subfamily. | Isocitrate dehydrogenase, NADP-dependent; COG: COG0538; Pfam: PF00180; InterPro: IPR004439. | 0.518 |
| nudJ | rluE | HMPREF0758_4139 | HMPREF0758_4137 | Phosphatase NudJ; COG: COG0494; Pfam: PF00293; InterPro: IPR000086; Belongs to the Nudix hydrolase family. NudJ subfamily. | Ribosomal large subunit pseudouridine synthase E; COG: COG1187; Pfam: PF00849; InterPro: IPR000748; Belongs to the pseudouridine synthase RsuA family. | 0.749 |
| nudJ | trmU | HMPREF0758_4139 | HMPREF0758_4140 | Phosphatase NudJ; COG: COG0494; Pfam: PF00293; InterPro: IPR000086; Belongs to the Nudix hydrolase family. NudJ subfamily. | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln), leading to the formation of s(2)U34, the first step of tRNA-mnm(5)s(2)U34 synthesis. Sulfur is provided by IscS, via a sulfur-relay system. Binds ATP and its substrate tRNAs; Belongs to the MnmA/TRMU family. | 0.572 |
| rluB | cmk | HMPREF0758_3552 | HMPREF0758_4384 | Pseudouridine synthase B, ribosomal large subunit; COG: COG1187; Pfam: PF01479,PF00849; InterPro: IPR000748; Belongs to the pseudouridine synthase RsuA family. | Cytidylate kinase; COG: COG0283; Pfam: PF02224; InterPro: IPR003136. | 0.748 |
| rluB | der | HMPREF0758_3552 | HMPREF0758_2505 | Pseudouridine synthase B, ribosomal large subunit; COG: COG1187; Pfam: PF01479,PF00849; InterPro: IPR000748; Belongs to the pseudouridine synthase RsuA family. | Ribosome biogenesis GTPase Der; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | 0.838 |