| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EFE94043.1 | icd | HMPREF0758_4138 | HMPREF0758_4136 | Hypothetical protein; COG: COG4461. | Isocitrate dehydrogenase, NADP-dependent; COG: COG0538; Pfam: PF00180; InterPro: IPR004439. | 0.499 |
| EFE94043.1 | nudJ | HMPREF0758_4138 | HMPREF0758_4139 | Hypothetical protein; COG: COG4461. | Phosphatase NudJ; COG: COG0494; Pfam: PF00293; InterPro: IPR000086; Belongs to the Nudix hydrolase family. NudJ subfamily. | 0.780 |
| EFE94043.1 | rluE | HMPREF0758_4138 | HMPREF0758_4137 | Hypothetical protein; COG: COG4461. | Ribosomal large subunit pseudouridine synthase E; COG: COG1187; Pfam: PF00849; InterPro: IPR000748; Belongs to the pseudouridine synthase RsuA family. | 0.732 |
| EFE94043.1 | trmU | HMPREF0758_4138 | HMPREF0758_4140 | Hypothetical protein; COG: COG4461. | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln), leading to the formation of s(2)U34, the first step of tRNA-mnm(5)s(2)U34 synthesis. Sulfur is provided by IscS, via a sulfur-relay system. Binds ATP and its substrate tRNAs; Belongs to the MnmA/TRMU family. | 0.534 |
| hemY | holA | HMPREF0758_1528 | HMPREF0758_4912 | hemY protein; COG: COG3071; Pfam: PF07219,PF07719; InterPro: IPR005254. | DNA polymerase III, delta subunit; COG: COG1466; Pfam: PF06144; InterPro: IPR005790. | 0.681 |
| hemY | lolB | HMPREF0758_1528 | HMPREF0758_3390 | hemY protein; COG: COG3071; Pfam: PF07219,PF07719; InterPro: IPR005254. | Outer membrane lipoprotein LolB; Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein. | 0.783 |
| hemY | nudJ | HMPREF0758_1528 | HMPREF0758_4139 | hemY protein; COG: COG3071; Pfam: PF07219,PF07719; InterPro: IPR005254. | Phosphatase NudJ; COG: COG0494; Pfam: PF00293; InterPro: IPR000086; Belongs to the Nudix hydrolase family. NudJ subfamily. | 0.475 |
| hemY | yfhD | HMPREF0758_1528 | HMPREF0758_2468 | hemY protein; COG: COG3071; Pfam: PF07219,PF07719; InterPro: IPR005254. | Transglycosylase SLT domain protein; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. | 0.485 |
| hflD | nudJ | HMPREF0758_4141 | HMPREF0758_4139 | Hypothetical protein; COG: COG2915; Pfam: PF04356; InterPro: IPR007451. | Phosphatase NudJ; COG: COG0494; Pfam: PF00293; InterPro: IPR000086; Belongs to the Nudix hydrolase family. NudJ subfamily. | 0.465 |
| hflD | trmU | HMPREF0758_4141 | HMPREF0758_4140 | Hypothetical protein; COG: COG2915; Pfam: PF04356; InterPro: IPR007451. | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln), leading to the formation of s(2)U34, the first step of tRNA-mnm(5)s(2)U34 synthesis. Sulfur is provided by IscS, via a sulfur-relay system. Binds ATP and its substrate tRNAs; Belongs to the MnmA/TRMU family. | 0.834 |
| holA | hemY | HMPREF0758_4912 | HMPREF0758_1528 | DNA polymerase III, delta subunit; COG: COG1466; Pfam: PF06144; InterPro: IPR005790. | hemY protein; COG: COG3071; Pfam: PF07219,PF07719; InterPro: IPR005254. | 0.681 |
| holA | lolB | HMPREF0758_4912 | HMPREF0758_3390 | DNA polymerase III, delta subunit; COG: COG1466; Pfam: PF06144; InterPro: IPR005790. | Outer membrane lipoprotein LolB; Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein. | 0.594 |
| holA | nudJ | HMPREF0758_4912 | HMPREF0758_4139 | DNA polymerase III, delta subunit; COG: COG1466; Pfam: PF06144; InterPro: IPR005790. | Phosphatase NudJ; COG: COG0494; Pfam: PF00293; InterPro: IPR000086; Belongs to the Nudix hydrolase family. NudJ subfamily. | 0.468 |
| icd | EFE94043.1 | HMPREF0758_4136 | HMPREF0758_4138 | Isocitrate dehydrogenase, NADP-dependent; COG: COG0538; Pfam: PF00180; InterPro: IPR004439. | Hypothetical protein; COG: COG4461. | 0.499 |
| icd | nudJ | HMPREF0758_4136 | HMPREF0758_4139 | Isocitrate dehydrogenase, NADP-dependent; COG: COG0538; Pfam: PF00180; InterPro: IPR004439. | Phosphatase NudJ; COG: COG0494; Pfam: PF00293; InterPro: IPR000086; Belongs to the Nudix hydrolase family. NudJ subfamily. | 0.518 |
| icd | rluE | HMPREF0758_4136 | HMPREF0758_4137 | Isocitrate dehydrogenase, NADP-dependent; COG: COG0538; Pfam: PF00180; InterPro: IPR004439. | Ribosomal large subunit pseudouridine synthase E; COG: COG1187; Pfam: PF00849; InterPro: IPR000748; Belongs to the pseudouridine synthase RsuA family. | 0.561 |
| lolB | hemY | HMPREF0758_3390 | HMPREF0758_1528 | Outer membrane lipoprotein LolB; Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein. | hemY protein; COG: COG3071; Pfam: PF07219,PF07719; InterPro: IPR005254. | 0.783 |
| lolB | holA | HMPREF0758_3390 | HMPREF0758_4912 | Outer membrane lipoprotein LolB; Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein. | DNA polymerase III, delta subunit; COG: COG1466; Pfam: PF06144; InterPro: IPR005790. | 0.594 |
| lolB | nudJ | HMPREF0758_3390 | HMPREF0758_4139 | Outer membrane lipoprotein LolB; Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein. | Phosphatase NudJ; COG: COG0494; Pfam: PF00293; InterPro: IPR000086; Belongs to the Nudix hydrolase family. NudJ subfamily. | 0.526 |
| nudJ | EFE94043.1 | HMPREF0758_4139 | HMPREF0758_4138 | Phosphatase NudJ; COG: COG0494; Pfam: PF00293; InterPro: IPR000086; Belongs to the Nudix hydrolase family. NudJ subfamily. | Hypothetical protein; COG: COG4461. | 0.780 |