| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EFE94076.1 | LpoB | HMPREF0758_4171 | HMPREF0758_4174 | Hypothetical protein; COG: COG3150; Pfam: PF05728; InterPro: IPR008886; Belongs to the UPF0227 family. | Hypothetical protein; COG: COG3417. | 0.597 |
| EFE94076.1 | nagZ | HMPREF0758_4171 | HMPREF0758_4172 | Hypothetical protein; COG: COG3150; Pfam: PF05728; InterPro: IPR008886; Belongs to the UPF0227 family. | Glycosyl hydrolase family 3 N-terminal domain protein; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. | 0.656 |
| EFE94076.1 | thiK | HMPREF0758_4171 | HMPREF0758_4173 | Hypothetical protein; COG: COG3150; Pfam: PF05728; InterPro: IPR008886; Belongs to the UPF0227 family. | Putative thiamine diphosphokinase; Catalyzes the phosphorylation of thiamine to thiamine phosphate. | 0.603 |
| Exo_I | NagK | HMPREF0758_0755 | HMPREF0758_4164 | Glycosyl hydrolase family 20, catalytic domain protein; COG: COG3525; Pfam: PF02838,PF00728; InterPro: IPR013781. | ROK family protein; COG: COG1940; Pfam: PF00480; InterPro: IPR000600. | 0.918 |
| Exo_I | chb-2 | HMPREF0758_0755 | HMPREF0758_4882 | Glycosyl hydrolase family 20, catalytic domain protein; COG: COG3525; Pfam: PF02838,PF00728; InterPro: IPR013781. | Chitobiase; COG: COG3525; Pfam: PF03173,PF02838,PF00728,PF03174; InterPro: IPR013781. | 0.924 |
| Exo_I | chiC | HMPREF0758_0755 | HMPREF0758_4891 | Glycosyl hydrolase family 20, catalytic domain protein; COG: COG3525; Pfam: PF02838,PF00728; InterPro: IPR013781. | Chitinase C1; COG: COG3469; Pfam: PF00704,PF00041,PF02839; InterPro: IPR001223; Belongs to the glycosyl hydrolase 18 family. | 0.947 |
| Exo_I | nagZ | HMPREF0758_0755 | HMPREF0758_4172 | Glycosyl hydrolase family 20, catalytic domain protein; COG: COG3525; Pfam: PF02838,PF00728; InterPro: IPR013781. | Glycosyl hydrolase family 3 N-terminal domain protein; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. | 0.908 |
| LpoB | EFE94076.1 | HMPREF0758_4174 | HMPREF0758_4171 | Hypothetical protein; COG: COG3417. | Hypothetical protein; COG: COG3150; Pfam: PF05728; InterPro: IPR008886; Belongs to the UPF0227 family. | 0.597 |
| LpoB | nagZ | HMPREF0758_4174 | HMPREF0758_4172 | Hypothetical protein; COG: COG3417. | Glycosyl hydrolase family 3 N-terminal domain protein; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. | 0.704 |
| LpoB | thiK | HMPREF0758_4174 | HMPREF0758_4173 | Hypothetical protein; COG: COG3417. | Putative thiamine diphosphokinase; Catalyzes the phosphorylation of thiamine to thiamine phosphate. | 0.898 |
| NagK | Exo_I | HMPREF0758_4164 | HMPREF0758_0755 | ROK family protein; COG: COG1940; Pfam: PF00480; InterPro: IPR000600. | Glycosyl hydrolase family 20, catalytic domain protein; COG: COG3525; Pfam: PF02838,PF00728; InterPro: IPR013781. | 0.918 |
| NagK | chb-2 | HMPREF0758_4164 | HMPREF0758_4882 | ROK family protein; COG: COG1940; Pfam: PF00480; InterPro: IPR000600. | Chitobiase; COG: COG3525; Pfam: PF03173,PF02838,PF00728,PF03174; InterPro: IPR013781. | 0.905 |
| NagK | chiC | HMPREF0758_4164 | HMPREF0758_4891 | ROK family protein; COG: COG1940; Pfam: PF00480; InterPro: IPR000600. | Chitinase C1; COG: COG3469; Pfam: PF00704,PF00041,PF02839; InterPro: IPR001223; Belongs to the glycosyl hydrolase 18 family. | 0.906 |
| NagK | nagZ | HMPREF0758_4164 | HMPREF0758_4172 | ROK family protein; COG: COG1940; Pfam: PF00480; InterPro: IPR000600. | Glycosyl hydrolase family 3 N-terminal domain protein; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. | 0.905 |
| ampG | anmK | HMPREF0758_0205 | HMPREF0758_3902 | Muropeptide transporter; COG: COG0477; Pfam: PF07690; InterPro: IPR011701. | anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | 0.480 |
| ampG | nagZ | HMPREF0758_0205 | HMPREF0758_4172 | Muropeptide transporter; COG: COG0477; Pfam: PF07690; InterPro: IPR011701. | Glycosyl hydrolase family 3 N-terminal domain protein; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. | 0.559 |
| anmK | ampG | HMPREF0758_3902 | HMPREF0758_0205 | anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | Muropeptide transporter; COG: COG0477; Pfam: PF07690; InterPro: IPR011701. | 0.480 |
| anmK | nagZ | HMPREF0758_3902 | HMPREF0758_4172 | anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | Glycosyl hydrolase family 3 N-terminal domain protein; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. | 0.639 |
| chb-2 | Exo_I | HMPREF0758_4882 | HMPREF0758_0755 | Chitobiase; COG: COG3525; Pfam: PF03173,PF02838,PF00728,PF03174; InterPro: IPR013781. | Glycosyl hydrolase family 20, catalytic domain protein; COG: COG3525; Pfam: PF02838,PF00728; InterPro: IPR013781. | 0.924 |
| chb-2 | NagK | HMPREF0758_4882 | HMPREF0758_4164 | Chitobiase; COG: COG3525; Pfam: PF03173,PF02838,PF00728,PF03174; InterPro: IPR013781. | ROK family protein; COG: COG1940; Pfam: PF00480; InterPro: IPR000600. | 0.905 |