| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| edd | pabC | HMPREF0758_1686 | HMPREF0758_4184 | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | Aminodeoxychorismate lyase; COG: COG0115; Pfam: PF01063; InterPro: IPR001544. | 0.677 |
| edd | thrA | HMPREF0758_1686 | HMPREF0758_0591 | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | Homoserine dehydrogenase; COG: COG0527; Pfam: PF00696,PF01842,PF03447,PF00742; InterPro: IPR001341; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.578 |
| folP | pabB | HMPREF0758_0809 | HMPREF0758_3332 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Aminodeoxychorismate synthase, component I; COG: COG0147; Pfam: PF04715,PF00425; InterPro: IPR005801. | 0.612 |
| folP | pabC | HMPREF0758_0809 | HMPREF0758_4184 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Aminodeoxychorismate lyase; COG: COG0115; Pfam: PF01063; InterPro: IPR001544. | 0.939 |
| folP | trpG | HMPREF0758_0809 | HMPREF0758_1000 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Glutamine amidotransferase, class I; COG: COG0512; Pfam: PF00117; InterPro: IPR006221. | 0.687 |
| holB | mltG | HMPREF0758_4181 | HMPREF0758_4183 | DNA polymerase III, delta' subunit; COG: COG0470; Pfam: PF09115; InterPro: IPR004622. | YceG family protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. | 0.843 |
| holB | pabC | HMPREF0758_4181 | HMPREF0758_4184 | DNA polymerase III, delta' subunit; COG: COG0470; Pfam: PF09115; InterPro: IPR004622. | Aminodeoxychorismate lyase; COG: COG0115; Pfam: PF01063; InterPro: IPR001544. | 0.792 |
| holB | tmk | HMPREF0758_4181 | HMPREF0758_4182 | DNA polymerase III, delta' subunit; COG: COG0470; Pfam: PF09115; InterPro: IPR004622. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.952 |
| holB | ycfH | HMPREF0758_4181 | HMPREF0758_4180 | DNA polymerase III, delta' subunit; COG: COG0470; Pfam: PF09115; InterPro: IPR004622. | Hydrolase, TatD family; COG: COG0084; Pfam: PF01026; InterPro: IPR001130. | 0.844 |
| ilvD | pabC | HMPREF0758_1131 | HMPREF0758_4184 | Dihydroxy-acid dehydratase; COG: COG0129; Pfam: PF00920; InterPro: IPR004404; Belongs to the IlvD/Edd family. | Aminodeoxychorismate lyase; COG: COG0115; Pfam: PF01063; InterPro: IPR001544. | 0.677 |
| ilvD | thrA | HMPREF0758_1131 | HMPREF0758_0591 | Dihydroxy-acid dehydratase; COG: COG0129; Pfam: PF00920; InterPro: IPR004404; Belongs to the IlvD/Edd family. | Homoserine dehydrogenase; COG: COG0527; Pfam: PF00696,PF01842,PF03447,PF00742; InterPro: IPR001341; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.578 |
| mltG | holB | HMPREF0758_4183 | HMPREF0758_4181 | YceG family protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. | DNA polymerase III, delta' subunit; COG: COG0470; Pfam: PF09115; InterPro: IPR004622. | 0.843 |
| mltG | pabC | HMPREF0758_4183 | HMPREF0758_4184 | YceG family protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. | Aminodeoxychorismate lyase; COG: COG0115; Pfam: PF01063; InterPro: IPR001544. | 0.835 |
| mltG | tmk | HMPREF0758_4183 | HMPREF0758_4182 | YceG family protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.846 |
| mltG | ycfH | HMPREF0758_4183 | HMPREF0758_4180 | YceG family protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. | Hydrolase, TatD family; COG: COG0084; Pfam: PF01026; InterPro: IPR001130. | 0.923 |
| pabB | folP | HMPREF0758_3332 | HMPREF0758_0809 | Aminodeoxychorismate synthase, component I; COG: COG0147; Pfam: PF04715,PF00425; InterPro: IPR005801. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.612 |
| pabB | pabC | HMPREF0758_3332 | HMPREF0758_4184 | Aminodeoxychorismate synthase, component I; COG: COG0147; Pfam: PF04715,PF00425; InterPro: IPR005801. | Aminodeoxychorismate lyase; COG: COG0115; Pfam: PF01063; InterPro: IPR001544. | 0.959 |
| pabB | thrA | HMPREF0758_3332 | HMPREF0758_0591 | Aminodeoxychorismate synthase, component I; COG: COG0147; Pfam: PF04715,PF00425; InterPro: IPR005801. | Homoserine dehydrogenase; COG: COG0527; Pfam: PF00696,PF01842,PF03447,PF00742; InterPro: IPR001341; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.419 |
| pabB | trpG | HMPREF0758_3332 | HMPREF0758_1000 | Aminodeoxychorismate synthase, component I; COG: COG0147; Pfam: PF04715,PF00425; InterPro: IPR005801. | Glutamine amidotransferase, class I; COG: COG0512; Pfam: PF00117; InterPro: IPR006221. | 0.999 |
| pabC | edd | HMPREF0758_4184 | HMPREF0758_1686 | Aminodeoxychorismate lyase; COG: COG0115; Pfam: PF01063; InterPro: IPR001544. | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | 0.677 |