| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EFE97637.1 | NucA | HMPREF0758_0726 | HMPREF0758_4286 | Hypothetical protein; COG: COG4268. | DNA/RNA non-specific endonuclease; COG: COG1864; Pfam: PF01223; InterPro: IPR001604. | 0.461 |
| EFE97637.1 | cadC | HMPREF0758_0726 | HMPREF0758_2352 | Hypothetical protein; COG: COG4268. | Transcriptional regulatory protein, C-terminal domain protein; COG: COG3710; Pfam: PF00486; InterPro: IPR011991. | 0.482 |
| EFE97637.1 | mcrB | HMPREF0758_0726 | HMPREF0758_0725 | Hypothetical protein; COG: COG4268. | ATPase family associated with various cellular activities (AAA); COG: COG1401; Pfam: PF07728; InterPro: IPR011704. | 0.997 |
| HcaD | NucA | HMPREF0758_2186 | HMPREF0758_4286 | Pyridine nucleotide-disulfide oxidoreductase; COG: COG0446; Pfam: PF07992,PF00070; InterPro: IPR013027. | DNA/RNA non-specific endonuclease; COG: COG1864; Pfam: PF01223; InterPro: IPR001604. | 0.407 |
| HcaD | nuoD | HMPREF0758_2186 | HMPREF0758_2794 | Pyridine nucleotide-disulfide oxidoreductase; COG: COG0446; Pfam: PF07992,PF00070; InterPro: IPR013027. | NADH dehydrogenase subunit D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the C-terminal section; belongs to the complex I 49 kDa subunit family. | 0.408 |
| InlA | NucA | HMPREF0758_3435 | HMPREF0758_4286 | Leucine Rich Repeat protein; COG: COG4886; Pfam: PF00560. | DNA/RNA non-specific endonuclease; COG: COG1864; Pfam: PF01223; InterPro: IPR001604. | 0.400 |
| NucA | EFE97637.1 | HMPREF0758_4286 | HMPREF0758_0726 | DNA/RNA non-specific endonuclease; COG: COG1864; Pfam: PF01223; InterPro: IPR001604. | Hypothetical protein; COG: COG4268. | 0.461 |
| NucA | HcaD | HMPREF0758_4286 | HMPREF0758_2186 | DNA/RNA non-specific endonuclease; COG: COG1864; Pfam: PF01223; InterPro: IPR001604. | Pyridine nucleotide-disulfide oxidoreductase; COG: COG0446; Pfam: PF07992,PF00070; InterPro: IPR013027. | 0.407 |
| NucA | InlA | HMPREF0758_4286 | HMPREF0758_3435 | DNA/RNA non-specific endonuclease; COG: COG1864; Pfam: PF01223; InterPro: IPR001604. | Leucine Rich Repeat protein; COG: COG4886; Pfam: PF00560. | 0.400 |
| NucA | cadC | HMPREF0758_4286 | HMPREF0758_2352 | DNA/RNA non-specific endonuclease; COG: COG1864; Pfam: PF01223; InterPro: IPR001604. | Transcriptional regulatory protein, C-terminal domain protein; COG: COG3710; Pfam: PF00486; InterPro: IPR011991. | 0.427 |
| NucA | mcrB | HMPREF0758_4286 | HMPREF0758_0725 | DNA/RNA non-specific endonuclease; COG: COG1864; Pfam: PF01223; InterPro: IPR001604. | ATPase family associated with various cellular activities (AAA); COG: COG1401; Pfam: PF07728; InterPro: IPR011704. | 0.484 |
| NucA | nuoD | HMPREF0758_4286 | HMPREF0758_2794 | DNA/RNA non-specific endonuclease; COG: COG1864; Pfam: PF01223; InterPro: IPR001604. | NADH dehydrogenase subunit D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the C-terminal section; belongs to the complex I 49 kDa subunit family. | 0.425 |
| NucA | nuoF | HMPREF0758_4286 | HMPREF0758_2796 | DNA/RNA non-specific endonuclease; COG: COG1864; Pfam: PF01223; InterPro: IPR001604. | NADH oxidoreductase (quinone), F subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Belongs to the complex I 51 kDa subunit family. | 0.666 |
| NucA | opuD | HMPREF0758_4286 | HMPREF0758_4285 | DNA/RNA non-specific endonuclease; COG: COG1864; Pfam: PF01223; InterPro: IPR001604. | Transporter, betaine/carnitine/choline family; COG: COG1292; Pfam: PF02028; InterPro: IPR000060; Belongs to the BCCT transporter (TC 2.A.15) family. | 0.431 |
| NucA | polA | HMPREF0758_4286 | HMPREF0758_1303 | DNA/RNA non-specific endonuclease; COG: COG1864; Pfam: PF01223; InterPro: IPR001604. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.521 |
| NucA | yeaD | HMPREF0758_4286 | HMPREF0758_3491 | DNA/RNA non-specific endonuclease; COG: COG1864; Pfam: PF01223; InterPro: IPR001604. | Aldose 1-epimerase; COG: COG0676; Pfam: PF01263; InterPro: IPR014718; Belongs to the glucose-6-phosphate 1-epimerase family. | 0.600 |
| cadC | EFE97637.1 | HMPREF0758_2352 | HMPREF0758_0726 | Transcriptional regulatory protein, C-terminal domain protein; COG: COG3710; Pfam: PF00486; InterPro: IPR011991. | Hypothetical protein; COG: COG4268. | 0.482 |
| cadC | NucA | HMPREF0758_2352 | HMPREF0758_4286 | Transcriptional regulatory protein, C-terminal domain protein; COG: COG3710; Pfam: PF00486; InterPro: IPR011991. | DNA/RNA non-specific endonuclease; COG: COG1864; Pfam: PF01223; InterPro: IPR001604. | 0.427 |
| cadC | mcrB | HMPREF0758_2352 | HMPREF0758_0725 | Transcriptional regulatory protein, C-terminal domain protein; COG: COG3710; Pfam: PF00486; InterPro: IPR011991. | ATPase family associated with various cellular activities (AAA); COG: COG1401; Pfam: PF07728; InterPro: IPR011704. | 0.446 |
| mcrB | EFE97637.1 | HMPREF0758_0725 | HMPREF0758_0726 | ATPase family associated with various cellular activities (AAA); COG: COG1401; Pfam: PF07728; InterPro: IPR011704. | Hypothetical protein; COG: COG4268. | 0.997 |