| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| aad | focA | HMPREF0758_3517 | HMPREF0758_4437 | Aldehyde dehydrogenase (NAD) family protein; COG: COG1454; Pfam: PF00171,PF00465; InterPro: IPR001670; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | Formate transporter FocA; COG: COG2116; Pfam: PF01226; InterPro: IPR000292. | 0.496 |
| aad | gltB | HMPREF0758_3517 | HMPREF0758_1877 | Aldehyde dehydrogenase (NAD) family protein; COG: COG1454; Pfam: PF00171,PF00465; InterPro: IPR001670; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | Class II glutamine amidotransferase; COG: COG0069; Pfam: PF00310,PF04898,PF01645,PF01493; InterPro: IPR013785. | 0.557 |
| aad | nirB-2 | HMPREF0758_3517 | HMPREF0758_3251 | Aldehyde dehydrogenase (NAD) family protein; COG: COG1454; Pfam: PF00171,PF00465; InterPro: IPR001670; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | Nitrite reductase [NAD(P)H], large subunit; COG: COG1251; Pfam: PF07992,PF00070,PF04324,PF03460,PF01077; InterPro: IPR012744; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.742 |
| aad | pflA-2 | HMPREF0758_3517 | HMPREF0758_4439 | Aldehyde dehydrogenase (NAD) family protein; COG: COG1454; Pfam: PF00171,PF00465; InterPro: IPR001670; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | Pyruvate formate-lyase 1-activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. | 0.876 |
| aad | pflB | HMPREF0758_3517 | HMPREF0758_4438 | Aldehyde dehydrogenase (NAD) family protein; COG: COG1454; Pfam: PF00171,PF00465; InterPro: IPR001670; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | Formate C-acetyltransferase; COG: COG1882; Pfam: PF02901,PF01228; InterPro: IPR005949. | 0.981 |
| cah | cah-2 | HMPREF0758_0917 | HMPREF0758_2031 | Carbonate dehydratase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. | Carbonate dehydratase; COG: COG0288; Pfam: PF00484; InterPro: IPR001765. | 0.921 |
| cah | cah-3 | HMPREF0758_0917 | HMPREF0758_2152 | Carbonate dehydratase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. | Carbonate dehydratase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. | 0.910 |
| cah | focA | HMPREF0758_0917 | HMPREF0758_4437 | Carbonate dehydratase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. | Formate transporter FocA; COG: COG2116; Pfam: PF01226; InterPro: IPR000292. | 0.535 |
| cah-2 | cah | HMPREF0758_2031 | HMPREF0758_0917 | Carbonate dehydratase; COG: COG0288; Pfam: PF00484; InterPro: IPR001765. | Carbonate dehydratase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. | 0.921 |
| cah-2 | cah-3 | HMPREF0758_2031 | HMPREF0758_2152 | Carbonate dehydratase; COG: COG0288; Pfam: PF00484; InterPro: IPR001765. | Carbonate dehydratase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. | 0.916 |
| cah-2 | focA | HMPREF0758_2031 | HMPREF0758_4437 | Carbonate dehydratase; COG: COG0288; Pfam: PF00484; InterPro: IPR001765. | Formate transporter FocA; COG: COG2116; Pfam: PF01226; InterPro: IPR000292. | 0.535 |
| cah-3 | cah | HMPREF0758_2152 | HMPREF0758_0917 | Carbonate dehydratase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. | Carbonate dehydratase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. | 0.910 |
| cah-3 | cah-2 | HMPREF0758_2152 | HMPREF0758_2031 | Carbonate dehydratase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. | Carbonate dehydratase; COG: COG0288; Pfam: PF00484; InterPro: IPR001765. | 0.916 |
| cah-3 | focA | HMPREF0758_2152 | HMPREF0758_4437 | Carbonate dehydratase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. | Formate transporter FocA; COG: COG2116; Pfam: PF01226; InterPro: IPR000292. | 0.535 |
| focA | aad | HMPREF0758_4437 | HMPREF0758_3517 | Formate transporter FocA; COG: COG2116; Pfam: PF01226; InterPro: IPR000292. | Aldehyde dehydrogenase (NAD) family protein; COG: COG1454; Pfam: PF00171,PF00465; InterPro: IPR001670; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | 0.496 |
| focA | cah | HMPREF0758_4437 | HMPREF0758_0917 | Formate transporter FocA; COG: COG2116; Pfam: PF01226; InterPro: IPR000292. | Carbonate dehydratase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. | 0.535 |
| focA | cah-2 | HMPREF0758_4437 | HMPREF0758_2031 | Formate transporter FocA; COG: COG2116; Pfam: PF01226; InterPro: IPR000292. | Carbonate dehydratase; COG: COG0288; Pfam: PF00484; InterPro: IPR001765. | 0.535 |
| focA | cah-3 | HMPREF0758_4437 | HMPREF0758_2152 | Formate transporter FocA; COG: COG2116; Pfam: PF01226; InterPro: IPR000292. | Carbonate dehydratase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. | 0.535 |
| focA | gltB | HMPREF0758_4437 | HMPREF0758_1877 | Formate transporter FocA; COG: COG2116; Pfam: PF01226; InterPro: IPR000292. | Class II glutamine amidotransferase; COG: COG0069; Pfam: PF00310,PF04898,PF01645,PF01493; InterPro: IPR013785. | 0.441 |
| focA | nirB-2 | HMPREF0758_4437 | HMPREF0758_3251 | Formate transporter FocA; COG: COG2116; Pfam: PF01226; InterPro: IPR000292. | Nitrite reductase [NAD(P)H], large subunit; COG: COG1251; Pfam: PF07992,PF00070,PF04324,PF03460,PF01077; InterPro: IPR012744; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.533 |