| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EFE95393.1 | trxB | HMPREF0758_3084 | HMPREF0758_4452 | Pyridoxamine 5'-phosphate oxidase family protein; COG: COG3576; Pfam: PF01243; InterPro: IPR011576. | Thioredoxin-disulfide reductase; COG: COG0492; Pfam: PF07992,PF00070; InterPro: IPR005982. | 0.624 |
| ahpC | bcsC | HMPREF0758_0236 | HMPREF0758_1498 | Antioxidant, AhpC/TSA family; COG: COG0450; Pfam: PF00578; InterPro: IPR012335. | Tetratricopeptide repeat protein; COG: COG0457; Pfam: PF07719,PF00515,PF05420; InterPro: IPR011990. | 0.434 |
| ahpC | trxA | HMPREF0758_0236 | HMPREF0758_1508 | Antioxidant, AhpC/TSA family; COG: COG0450; Pfam: PF00578; InterPro: IPR012335. | Thioredoxin; COG: COG0526; Pfam: PF00085; InterPro: IPR012335; Belongs to the thioredoxin family. | 0.487 |
| ahpC | trxB | HMPREF0758_0236 | HMPREF0758_4452 | Antioxidant, AhpC/TSA family; COG: COG0450; Pfam: PF00578; InterPro: IPR012335. | Thioredoxin-disulfide reductase; COG: COG0492; Pfam: PF07992,PF00070; InterPro: IPR005982. | 0.924 |
| bcsC | ahpC | HMPREF0758_1498 | HMPREF0758_0236 | Tetratricopeptide repeat protein; COG: COG0457; Pfam: PF07719,PF00515,PF05420; InterPro: IPR011990. | Antioxidant, AhpC/TSA family; COG: COG0450; Pfam: PF00578; InterPro: IPR012335. | 0.434 |
| bcsC | trxB | HMPREF0758_1498 | HMPREF0758_4452 | Tetratricopeptide repeat protein; COG: COG0457; Pfam: PF07719,PF00515,PF05420; InterPro: IPR011990. | Thioredoxin-disulfide reductase; COG: COG0492; Pfam: PF07992,PF00070; InterPro: IPR005982. | 0.739 |
| csdB | selD | HMPREF0758_3938 | HMPREF0758_3500 | Bifunctional cysteine desulfurase/selenocysteine lyase; Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L- selenocysteine. Selenocysteine lyase activity is however unsure in vivo. | Selenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. | 0.912 |
| csdB | trxB | HMPREF0758_3938 | HMPREF0758_4452 | Bifunctional cysteine desulfurase/selenocysteine lyase; Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L- selenocysteine. Selenocysteine lyase activity is however unsure in vivo. | Thioredoxin-disulfide reductase; COG: COG0492; Pfam: PF07992,PF00070; InterPro: IPR005982. | 0.926 |
| metC5 | trxB | HMPREF0758_4526 | HMPREF0758_4452 | Cys/Met metabolism PLP-dependent enzyme; COG: COG0626; Pfam: PF01053; InterPro: IPR000277. | Thioredoxin-disulfide reductase; COG: COG0492; Pfam: PF07992,PF00070; InterPro: IPR005982. | 0.910 |
| metG | selD | HMPREF0758_4580 | HMPREF0758_3500 | methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | Selenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. | 0.408 |
| metG | trxB | HMPREF0758_4580 | HMPREF0758_4452 | methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | Thioredoxin-disulfide reductase; COG: COG0492; Pfam: PF07992,PF00070; InterPro: IPR005982. | 0.664 |
| selD | csdB | HMPREF0758_3500 | HMPREF0758_3938 | Selenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. | Bifunctional cysteine desulfurase/selenocysteine lyase; Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L- selenocysteine. Selenocysteine lyase activity is however unsure in vivo. | 0.912 |
| selD | metG | HMPREF0758_3500 | HMPREF0758_4580 | Selenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. | methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.408 |
| selD | trxB | HMPREF0758_3500 | HMPREF0758_4452 | Selenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. | Thioredoxin-disulfide reductase; COG: COG0492; Pfam: PF07992,PF00070; InterPro: IPR005982. | 0.918 |
| trxA | ahpC | HMPREF0758_1508 | HMPREF0758_0236 | Thioredoxin; COG: COG0526; Pfam: PF00085; InterPro: IPR012335; Belongs to the thioredoxin family. | Antioxidant, AhpC/TSA family; COG: COG0450; Pfam: PF00578; InterPro: IPR012335. | 0.487 |
| trxA | trxB | HMPREF0758_1508 | HMPREF0758_4452 | Thioredoxin; COG: COG0526; Pfam: PF00085; InterPro: IPR012335; Belongs to the thioredoxin family. | Thioredoxin-disulfide reductase; COG: COG0492; Pfam: PF07992,PF00070; InterPro: IPR005982. | 0.990 |
| trxA-2 | trxB | HMPREF0758_2376 | HMPREF0758_4452 | Thioredoxin; COG: COG0526; Pfam: PF00085; InterPro: IPR012335; Belongs to the thioredoxin family. | Thioredoxin-disulfide reductase; COG: COG0492; Pfam: PF07992,PF00070; InterPro: IPR005982. | 0.894 |
| trxB | EFE95393.1 | HMPREF0758_4452 | HMPREF0758_3084 | Thioredoxin-disulfide reductase; COG: COG0492; Pfam: PF07992,PF00070; InterPro: IPR005982. | Pyridoxamine 5'-phosphate oxidase family protein; COG: COG3576; Pfam: PF01243; InterPro: IPR011576. | 0.624 |
| trxB | ahpC | HMPREF0758_4452 | HMPREF0758_0236 | Thioredoxin-disulfide reductase; COG: COG0492; Pfam: PF07992,PF00070; InterPro: IPR005982. | Antioxidant, AhpC/TSA family; COG: COG0450; Pfam: PF00578; InterPro: IPR012335. | 0.924 |
| trxB | bcsC | HMPREF0758_4452 | HMPREF0758_1498 | Thioredoxin-disulfide reductase; COG: COG0492; Pfam: PF07992,PF00070; InterPro: IPR005982. | Tetratricopeptide repeat protein; COG: COG0457; Pfam: PF07719,PF00515,PF05420; InterPro: IPR011990. | 0.739 |