| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| aat | clpA | HMPREF0758_4455 | HMPREF0758_4457 | Leucyltransferase; Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl- tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine. | ATP-dependent Clp protease ATP-binding subunit ClpA; COG: COG0542; Pfam: PF02861,PF00004,PF07724; InterPro: IPR013461; Belongs to the ClpA/ClpB family. | 0.432 |
| aat | clpS | HMPREF0758_4455 | HMPREF0758_4458 | Leucyltransferase; Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl- tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine. | ATP-dependent Clp protease adaptor protein ClpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. | 0.794 |
| aat | cydC | HMPREF0758_4455 | HMPREF0758_4454 | Leucyltransferase; Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl- tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine. | Thiol reductant ABC exporter, CydC subunit; COG: COG4987; Pfam: PF00005; InterPro: IPR014223. | 0.701 |
| aat | cydD | HMPREF0758_4455 | HMPREF0758_4453 | Leucyltransferase; Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl- tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine. | Thiol reductant ABC exporter, CydD subunit; COG: COG4988; Pfam: PF00664,PF00005; InterPro: IPR014216. | 0.700 |
| aat | infA | HMPREF0758_4455 | HMPREF0758_4456 | Leucyltransferase; Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl- tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine. | Translation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. | 0.638 |
| aat | pheA | HMPREF0758_4455 | HMPREF0758_0402 | Leucyltransferase; Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl- tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine. | Chorismate mutase; COG: COG0077; Pfam: PF01817,PF00800; InterPro: IPR001086. | 0.424 |
| aat | trxB | HMPREF0758_4455 | HMPREF0758_4452 | Leucyltransferase; Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl- tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine. | Thioredoxin-disulfide reductase; COG: COG0492; Pfam: PF07992,PF00070; InterPro: IPR005982. | 0.453 |
| aat | tyrA | HMPREF0758_4455 | HMPREF0758_0403 | Leucyltransferase; Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl- tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine. | Chorismate mutase; COG: COG0287; Pfam: PF01817,PF02153; InterPro: IPR003099. | 0.421 |
| clpA | aat | HMPREF0758_4457 | HMPREF0758_4455 | ATP-dependent Clp protease ATP-binding subunit ClpA; COG: COG0542; Pfam: PF02861,PF00004,PF07724; InterPro: IPR013461; Belongs to the ClpA/ClpB family. | Leucyltransferase; Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl- tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine. | 0.432 |
| clpA | clpS | HMPREF0758_4457 | HMPREF0758_4458 | ATP-dependent Clp protease ATP-binding subunit ClpA; COG: COG0542; Pfam: PF02861,PF00004,PF07724; InterPro: IPR013461; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease adaptor protein ClpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. | 0.992 |
| clpS | aat | HMPREF0758_4458 | HMPREF0758_4455 | ATP-dependent Clp protease adaptor protein ClpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. | Leucyltransferase; Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl- tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine. | 0.794 |
| clpS | clpA | HMPREF0758_4458 | HMPREF0758_4457 | ATP-dependent Clp protease adaptor protein ClpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. | ATP-dependent Clp protease ATP-binding subunit ClpA; COG: COG0542; Pfam: PF02861,PF00004,PF07724; InterPro: IPR013461; Belongs to the ClpA/ClpB family. | 0.992 |
| cydC | aat | HMPREF0758_4454 | HMPREF0758_4455 | Thiol reductant ABC exporter, CydC subunit; COG: COG4987; Pfam: PF00005; InterPro: IPR014223. | Leucyltransferase; Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl- tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine. | 0.701 |
| cydC | cydD | HMPREF0758_4454 | HMPREF0758_4453 | Thiol reductant ABC exporter, CydC subunit; COG: COG4987; Pfam: PF00005; InterPro: IPR014223. | Thiol reductant ABC exporter, CydD subunit; COG: COG4988; Pfam: PF00664,PF00005; InterPro: IPR014216. | 0.999 |
| cydC | infA | HMPREF0758_4454 | HMPREF0758_4456 | Thiol reductant ABC exporter, CydC subunit; COG: COG4987; Pfam: PF00005; InterPro: IPR014223. | Translation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. | 0.476 |
| cydC | trxB | HMPREF0758_4454 | HMPREF0758_4452 | Thiol reductant ABC exporter, CydC subunit; COG: COG4987; Pfam: PF00005; InterPro: IPR014223. | Thioredoxin-disulfide reductase; COG: COG0492; Pfam: PF07992,PF00070; InterPro: IPR005982. | 0.491 |
| cydD | aat | HMPREF0758_4453 | HMPREF0758_4455 | Thiol reductant ABC exporter, CydD subunit; COG: COG4988; Pfam: PF00664,PF00005; InterPro: IPR014216. | Leucyltransferase; Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl- tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine. | 0.700 |
| cydD | cydC | HMPREF0758_4453 | HMPREF0758_4454 | Thiol reductant ABC exporter, CydD subunit; COG: COG4988; Pfam: PF00664,PF00005; InterPro: IPR014216. | Thiol reductant ABC exporter, CydC subunit; COG: COG4987; Pfam: PF00005; InterPro: IPR014223. | 0.999 |
| cydD | infA | HMPREF0758_4453 | HMPREF0758_4456 | Thiol reductant ABC exporter, CydD subunit; COG: COG4988; Pfam: PF00664,PF00005; InterPro: IPR014216. | Translation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. | 0.476 |
| cydD | trxB | HMPREF0758_4453 | HMPREF0758_4452 | Thiol reductant ABC exporter, CydD subunit; COG: COG4988; Pfam: PF00664,PF00005; InterPro: IPR014216. | Thioredoxin-disulfide reductase; COG: COG0492; Pfam: PF07992,PF00070; InterPro: IPR005982. | 0.517 |