| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EFE93578.1 | EFE96976.1 | HMPREF0758_4462 | HMPREF0758_1355 | Hypothetical protein; COG: COG2990; Pfam: PF04393; InterPro: IPR007488. | Hypothetical protein; COG: COG2091; Belongs to the P-Pant transferase superfamily. | 0.551 |
| EFE93578.1 | EFE97952.1 | HMPREF0758_4462 | HMPREF0758_0536 | Hypothetical protein; COG: COG2990; Pfam: PF04393; InterPro: IPR007488. | Hypothetical protein. | 0.442 |
| EFE93578.1 | YfeZ | HMPREF0758_4462 | HMPREF0758_2646 | Hypothetical protein; COG: COG2990; Pfam: PF04393; InterPro: IPR007488. | Hypothetical protein. | 0.669 |
| EFE93578.1 | macA | HMPREF0758_4462 | HMPREF0758_4461 | Hypothetical protein; COG: COG2990; Pfam: PF04393; InterPro: IPR007488. | Efflux transporter, RND family, MFP subunit; COG: COG0845; Pfam: PF00529; InterPro: IPR006143; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.496 |
| EFE93578.1 | macB | HMPREF0758_4462 | HMPREF0758_4460 | Hypothetical protein; COG: COG2990; Pfam: PF04393; InterPro: IPR007488. | ABC transporter, ATP-binding protein; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. | 0.523 |
| EFE93578.1 | matP | HMPREF0758_4462 | HMPREF0758_4339 | Hypothetical protein; COG: COG2990; Pfam: PF04393; InterPro: IPR007488. | Hypothetical protein; Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain. | 0.441 |
| EFE93578.1 | rfaL | HMPREF0758_4462 | HMPREF0758_1250 | Hypothetical protein; COG: COG2990; Pfam: PF04393; InterPro: IPR007488. | O-antigen ligase; Pfam: PF04932. | 0.440 |
| EFE93578.1 | stp-2 | HMPREF0758_4462 | HMPREF0758_3988 | Hypothetical protein; COG: COG2990; Pfam: PF04393; InterPro: IPR007488. | Serine transporter; COG: COG0814. | 0.461 |
| EFE93578.1 | stp-3 | HMPREF0758_4462 | HMPREF0758_4522 | Hypothetical protein; COG: COG2990; Pfam: PF04393; InterPro: IPR007488. | Serine transporter; COG: COG0814; InterPro: IPR004694. | 0.425 |
| EFE93578.1 | yejM | HMPREF0758_4462 | HMPREF0758_2856 | Hypothetical protein; COG: COG2990; Pfam: PF04393; InterPro: IPR007488. | Arylsulfatase; COG: COG3083; Pfam: PF00884; InterPro: IPR000917. | 0.434 |
| EFE96976.1 | EFE93578.1 | HMPREF0758_1355 | HMPREF0758_4462 | Hypothetical protein; COG: COG2091; Belongs to the P-Pant transferase superfamily. | Hypothetical protein; COG: COG2990; Pfam: PF04393; InterPro: IPR007488. | 0.551 |
| EFE96976.1 | yejM | HMPREF0758_1355 | HMPREF0758_2856 | Hypothetical protein; COG: COG2091; Belongs to the P-Pant transferase superfamily. | Arylsulfatase; COG: COG3083; Pfam: PF00884; InterPro: IPR000917. | 0.445 |
| EFE97952.1 | EFE93578.1 | HMPREF0758_0536 | HMPREF0758_4462 | Hypothetical protein. | Hypothetical protein; COG: COG2990; Pfam: PF04393; InterPro: IPR007488. | 0.442 |
| YfeZ | EFE93578.1 | HMPREF0758_2646 | HMPREF0758_4462 | Hypothetical protein. | Hypothetical protein; COG: COG2990; Pfam: PF04393; InterPro: IPR007488. | 0.669 |
| YfeZ | yejM | HMPREF0758_2646 | HMPREF0758_2856 | Hypothetical protein. | Arylsulfatase; COG: COG3083; Pfam: PF00884; InterPro: IPR000917. | 0.594 |
| macA | EFE93578.1 | HMPREF0758_4461 | HMPREF0758_4462 | Efflux transporter, RND family, MFP subunit; COG: COG0845; Pfam: PF00529; InterPro: IPR006143; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Hypothetical protein; COG: COG2990; Pfam: PF04393; InterPro: IPR007488. | 0.496 |
| macA | macB | HMPREF0758_4461 | HMPREF0758_4460 | Efflux transporter, RND family, MFP subunit; COG: COG0845; Pfam: PF00529; InterPro: IPR006143; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | ABC transporter, ATP-binding protein; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. | 0.998 |
| macB | EFE93578.1 | HMPREF0758_4460 | HMPREF0758_4462 | ABC transporter, ATP-binding protein; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. | Hypothetical protein; COG: COG2990; Pfam: PF04393; InterPro: IPR007488. | 0.523 |
| macB | macA | HMPREF0758_4460 | HMPREF0758_4461 | ABC transporter, ATP-binding protein; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. | Efflux transporter, RND family, MFP subunit; COG: COG0845; Pfam: PF00529; InterPro: IPR006143; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.998 |
| matP | EFE93578.1 | HMPREF0758_4339 | HMPREF0758_4462 | Hypothetical protein; Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain. | Hypothetical protein; COG: COG2990; Pfam: PF04393; InterPro: IPR007488. | 0.441 |