| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EFE93749.1 | betB-2 | HMPREF0758_4633 | HMPREF0758_4631 | Hypothetical protein. | Betaine-aldehyde dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid. | 0.449 |
| EFE93749.1 | betI | HMPREF0758_4633 | HMPREF0758_4632 | Hypothetical protein. | Transcriptional repressor BetI; Repressor involved in choline regulation of the bet genes. | 0.487 |
| betA | betB-2 | HMPREF0758_4630 | HMPREF0758_4631 | Choline dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate. | Betaine-aldehyde dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid. | 0.967 |
| betA | betI | HMPREF0758_4630 | HMPREF0758_4632 | Choline dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate. | Transcriptional repressor BetI; Repressor involved in choline regulation of the bet genes. | 0.895 |
| betA | gltB | HMPREF0758_4630 | HMPREF0758_1877 | Choline dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate. | Class II glutamine amidotransferase; COG: COG0069; Pfam: PF00310,PF04898,PF01645,PF01493; InterPro: IPR013785. | 0.408 |
| betA | hpaE2 | HMPREF0758_4630 | HMPREF0758_2192 | Choline dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate. | Aldehyde dehydrogenase (NAD) family protein; COG: COG1012; Pfam: PF00171; InterPro: IPR015590; Belongs to the aldehyde dehydrogenase family. | 0.910 |
| betB-2 | EFE93749.1 | HMPREF0758_4631 | HMPREF0758_4633 | Betaine-aldehyde dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid. | Hypothetical protein. | 0.449 |
| betB-2 | betA | HMPREF0758_4631 | HMPREF0758_4630 | Betaine-aldehyde dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid. | Choline dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate. | 0.967 |
| betB-2 | betI | HMPREF0758_4631 | HMPREF0758_4632 | Betaine-aldehyde dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid. | Transcriptional repressor BetI; Repressor involved in choline regulation of the bet genes. | 0.889 |
| betB-2 | fmt | HMPREF0758_4631 | HMPREF0758_0929 | Betaine-aldehyde dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.669 |
| betB-2 | gltB | HMPREF0758_4631 | HMPREF0758_1877 | Betaine-aldehyde dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid. | Class II glutamine amidotransferase; COG: COG0069; Pfam: PF00310,PF04898,PF01645,PF01493; InterPro: IPR013785. | 0.439 |
| betB-2 | hpaE2 | HMPREF0758_4631 | HMPREF0758_2192 | Betaine-aldehyde dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid. | Aldehyde dehydrogenase (NAD) family protein; COG: COG1012; Pfam: PF00171; InterPro: IPR015590; Belongs to the aldehyde dehydrogenase family. | 0.910 |
| betB-2 | nifJ | HMPREF0758_4631 | HMPREF0758_3621 | Betaine-aldehyde dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid. | Pyruvate synthase; COG: COG0674; Pfam: PF01855,PF01558,PF00037,PF02775; InterPro: IPR011895. | 0.544 |
| betB-2 | uca | HMPREF0758_4631 | HMPREF0758_4718 | Betaine-aldehyde dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid. | Urea carboxylase; COG: COG0439; Pfam: PF00289,PF02786,PF02785,PF02626,PF02682,PF00364; InterPro: IPR014084. | 0.459 |
| betI | EFE93749.1 | HMPREF0758_4632 | HMPREF0758_4633 | Transcriptional repressor BetI; Repressor involved in choline regulation of the bet genes. | Hypothetical protein. | 0.487 |
| betI | betA | HMPREF0758_4632 | HMPREF0758_4630 | Transcriptional repressor BetI; Repressor involved in choline regulation of the bet genes. | Choline dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate. | 0.895 |
| betI | betB-2 | HMPREF0758_4632 | HMPREF0758_4631 | Transcriptional repressor BetI; Repressor involved in choline regulation of the bet genes. | Betaine-aldehyde dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid. | 0.889 |
| fmt | betB-2 | HMPREF0758_0929 | HMPREF0758_4631 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Betaine-aldehyde dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid. | 0.669 |
| fmt | hpaE2 | HMPREF0758_0929 | HMPREF0758_2192 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Aldehyde dehydrogenase (NAD) family protein; COG: COG1012; Pfam: PF00171; InterPro: IPR015590; Belongs to the aldehyde dehydrogenase family. | 0.408 |
| gltB | betA | HMPREF0758_1877 | HMPREF0758_4630 | Class II glutamine amidotransferase; COG: COG0069; Pfam: PF00310,PF04898,PF01645,PF01493; InterPro: IPR013785. | Choline dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate. | 0.408 |