| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EFE93823.1 | sseA | HMPREF0758_4707 | HMPREF0758_4708 | Hydrolase, NUDIX family; Pfam: PF00293; InterPro: IPR000086. | Rhodanese-like protein; COG: COG2897; Pfam: PF00581; InterPro: IPR001763. | 0.534 |
| HcaD | sseA | HMPREF0758_2186 | HMPREF0758_4708 | Pyridine nucleotide-disulfide oxidoreductase; COG: COG0446; Pfam: PF07992,PF00070; InterPro: IPR013027. | Rhodanese-like protein; COG: COG2897; Pfam: PF00581; InterPro: IPR001763. | 0.412 |
| TrbB | sseA | HMPREF0758_5034 | HMPREF0758_4708 | type-F conjugative transfer system pilin assembly thiol-disulfide isomerase TrbB; InterPro: IPR014109. | Rhodanese-like protein; COG: COG2897; Pfam: PF00581; InterPro: IPR001763. | 0.571 |
| TrbB | traF | HMPREF0758_5034 | HMPREF0758_5036 | type-F conjugative transfer system pilin assembly thiol-disulfide isomerase TrbB; InterPro: IPR014109. | type-F conjugative transfer system pilin assembly protein TraF; InterPro: IPR014110. | 0.794 |
| cysB2 | cysI | HMPREF0758_4525 | HMPREF0758_0451 | Putative cystathionine beta-synthase; COG: COG0031; Pfam: PF00291,PF00571; InterPro: IPR001926. | Sulfite reductase (NADPH) hemoprotein, beta-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.602 |
| cysB2 | sseA | HMPREF0758_4525 | HMPREF0758_4708 | Putative cystathionine beta-synthase; COG: COG0031; Pfam: PF00291,PF00571; InterPro: IPR001926. | Rhodanese-like protein; COG: COG2897; Pfam: PF00581; InterPro: IPR001763. | 0.457 |
| cysI | cysB2 | HMPREF0758_0451 | HMPREF0758_4525 | Sulfite reductase (NADPH) hemoprotein, beta-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | Putative cystathionine beta-synthase; COG: COG0031; Pfam: PF00291,PF00571; InterPro: IPR001926. | 0.602 |
| cysI | sseA | HMPREF0758_0451 | HMPREF0758_4708 | Sulfite reductase (NADPH) hemoprotein, beta-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | Rhodanese-like protein; COG: COG2897; Pfam: PF00581; InterPro: IPR001763. | 0.429 |
| dsbE | sseA | HMPREF0758_2715 | HMPREF0758_4708 | Thiol:disulfide interchange protein DsbE; COG: COG0526; Pfam: PF08534; InterPro: IPR004799. | Rhodanese-like protein; COG: COG2897; Pfam: PF00581; InterPro: IPR001763. | 0.571 |
| iscS | sseA | HMPREF0758_2486 | HMPREF0758_4708 | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. | Rhodanese-like protein; COG: COG2897; Pfam: PF00581; InterPro: IPR001763. | 0.421 |
| iscS | thiI | HMPREF0758_2486 | HMPREF0758_0218 | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. | Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | 0.981 |
| scsD | sseA | HMPREF0758_2743 | HMPREF0758_4708 | Antioxidant, AhpC/TSA family; COG: COG0526; Pfam: PF00578; InterPro: IPR012335. | Rhodanese-like protein; COG: COG2897; Pfam: PF00581; InterPro: IPR001763. | 0.571 |
| sseA | EFE93823.1 | HMPREF0758_4708 | HMPREF0758_4707 | Rhodanese-like protein; COG: COG2897; Pfam: PF00581; InterPro: IPR001763. | Hydrolase, NUDIX family; Pfam: PF00293; InterPro: IPR000086. | 0.534 |
| sseA | HcaD | HMPREF0758_4708 | HMPREF0758_2186 | Rhodanese-like protein; COG: COG2897; Pfam: PF00581; InterPro: IPR001763. | Pyridine nucleotide-disulfide oxidoreductase; COG: COG0446; Pfam: PF07992,PF00070; InterPro: IPR013027. | 0.412 |
| sseA | TrbB | HMPREF0758_4708 | HMPREF0758_5034 | Rhodanese-like protein; COG: COG2897; Pfam: PF00581; InterPro: IPR001763. | type-F conjugative transfer system pilin assembly thiol-disulfide isomerase TrbB; InterPro: IPR014109. | 0.571 |
| sseA | cysB2 | HMPREF0758_4708 | HMPREF0758_4525 | Rhodanese-like protein; COG: COG2897; Pfam: PF00581; InterPro: IPR001763. | Putative cystathionine beta-synthase; COG: COG0031; Pfam: PF00291,PF00571; InterPro: IPR001926. | 0.457 |
| sseA | cysI | HMPREF0758_4708 | HMPREF0758_0451 | Rhodanese-like protein; COG: COG2897; Pfam: PF00581; InterPro: IPR001763. | Sulfite reductase (NADPH) hemoprotein, beta-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.429 |
| sseA | dsbE | HMPREF0758_4708 | HMPREF0758_2715 | Rhodanese-like protein; COG: COG2897; Pfam: PF00581; InterPro: IPR001763. | Thiol:disulfide interchange protein DsbE; COG: COG0526; Pfam: PF08534; InterPro: IPR004799. | 0.571 |
| sseA | iscS | HMPREF0758_4708 | HMPREF0758_2486 | Rhodanese-like protein; COG: COG2897; Pfam: PF00581; InterPro: IPR001763. | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. | 0.421 |
| sseA | scsD | HMPREF0758_4708 | HMPREF0758_2743 | Rhodanese-like protein; COG: COG2897; Pfam: PF00581; InterPro: IPR001763. | Antioxidant, AhpC/TSA family; COG: COG0526; Pfam: PF00578; InterPro: IPR012335. | 0.571 |