| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EFE93907.1 | Stp_1 | HMPREF0758_4791 | HMPREF0758_3161 | Hypothetical protein; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family. | Protein phosphatase 2C; COG: COG0631; Pfam: PF00481; InterPro: IPR001932. | 0.618 |
| EFE93907.1 | argR | HMPREF0758_4791 | HMPREF0758_0826 | Hypothetical protein; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family. | Arginine repressor; Regulates arginine biosynthesis genes. | 0.541 |
| EFE93907.1 | glmU | HMPREF0758_4791 | HMPREF0758_1336 | Hypothetical protein; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family. | UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | 0.506 |
| EFE93907.1 | rapZ | HMPREF0758_4791 | HMPREF0758_1848 | Hypothetical protein; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family. | Hypothetical protein; Modulates the synthesis of GlmS, by affecting the processing and stability of the regulatory small RNA GlmZ. When glucosamine-6- phosphate (GlcN6P) concentrations are high in the cell, RapZ binds GlmZ and targets it to cleavage by RNase E. Consequently, GlmZ is inactivated and unable to activate GlmS synthesis. Under low GlcN6P concentrations, RapZ is sequestered and inactivated by an other regulatory small RNA, GlmY, preventing GlmZ degradation and leading to synthesis of GlmS; Belongs to the RapZ-like family. RapZ subfamily. | 0.826 |
| EFE93907.1 | thiH | HMPREF0758_4791 | HMPREF0758_1665 | Hypothetical protein; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family. | Thiazole biosynthesis protein ThiH; COG: COG1060; Pfam: PF04055,PF06968; InterPro: IPR012726. | 0.406 |
| EFE93907.1 | wecG | HMPREF0758_4791 | HMPREF0758_1521 | Hypothetical protein; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family. | Glycosyltransferase, WecB/TagA/CpsF family; Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in enterobacterial common antigen (ECA) synthesis. | 0.502 |
| EFE93907.1 | zapA | HMPREF0758_4791 | HMPREF0758_2209 | Hypothetical protein; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family. | Cell division protein ZapA; Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division. | 0.438 |
| Stp_1 | EFE93907.1 | HMPREF0758_3161 | HMPREF0758_4791 | Protein phosphatase 2C; COG: COG0631; Pfam: PF00481; InterPro: IPR001932. | Hypothetical protein; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family. | 0.618 |
| argR | EFE93907.1 | HMPREF0758_0826 | HMPREF0758_4791 | Arginine repressor; Regulates arginine biosynthesis genes. | Hypothetical protein; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family. | 0.541 |
| glmU | EFE93907.1 | HMPREF0758_1336 | HMPREF0758_4791 | UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | Hypothetical protein; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family. | 0.506 |
| rapZ | EFE93907.1 | HMPREF0758_1848 | HMPREF0758_4791 | Hypothetical protein; Modulates the synthesis of GlmS, by affecting the processing and stability of the regulatory small RNA GlmZ. When glucosamine-6- phosphate (GlcN6P) concentrations are high in the cell, RapZ binds GlmZ and targets it to cleavage by RNase E. Consequently, GlmZ is inactivated and unable to activate GlmS synthesis. Under low GlcN6P concentrations, RapZ is sequestered and inactivated by an other regulatory small RNA, GlmY, preventing GlmZ degradation and leading to synthesis of GlmS; Belongs to the RapZ-like family. RapZ subfamily. | Hypothetical protein; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family. | 0.826 |
| thiH | EFE93907.1 | HMPREF0758_1665 | HMPREF0758_4791 | Thiazole biosynthesis protein ThiH; COG: COG1060; Pfam: PF04055,PF06968; InterPro: IPR012726. | Hypothetical protein; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family. | 0.406 |
| wecG | EFE93907.1 | HMPREF0758_1521 | HMPREF0758_4791 | Glycosyltransferase, WecB/TagA/CpsF family; Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in enterobacterial common antigen (ECA) synthesis. | Hypothetical protein; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family. | 0.502 |
| zapA | EFE93907.1 | HMPREF0758_2209 | HMPREF0758_4791 | Cell division protein ZapA; Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division. | Hypothetical protein; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family. | 0.438 |