| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| entB | fldA3 | HMPREF0758_2684 | HMPREF0758_4879 | Isochorismatase; COG: COG1535; Pfam: PF00857,PF00550; InterPro: IPR000868. | Flavodoxin; Low-potential electron donor to a number of redox enzymes. Belongs to the flavodoxin family. | 0.611 |
| fldA3 | entB | HMPREF0758_4879 | HMPREF0758_2684 | Flavodoxin; Low-potential electron donor to a number of redox enzymes. Belongs to the flavodoxin family. | Isochorismatase; COG: COG1535; Pfam: PF00857,PF00550; InterPro: IPR000868. | 0.611 |
| fldA3 | fur | HMPREF0758_4879 | HMPREF0758_4880 | Flavodoxin; Low-potential electron donor to a number of redox enzymes. Belongs to the flavodoxin family. | Transcriptional regulator, Fur family; COG: COG0735; Pfam: PF01475; InterPro: IPR002481; Belongs to the Fur family. | 0.639 |
| fldA3 | nifJ | HMPREF0758_4879 | HMPREF0758_3621 | Flavodoxin; Low-potential electron donor to a number of redox enzymes. Belongs to the flavodoxin family. | Pyruvate synthase; COG: COG0674; Pfam: PF01855,PF01558,PF00037,PF02775; InterPro: IPR011895. | 0.630 |
| fldA3 | nrdA | HMPREF0758_4879 | HMPREF0758_2829 | Flavodoxin; Low-potential electron donor to a number of redox enzymes. Belongs to the flavodoxin family. | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.408 |
| fldA3 | nrdB | HMPREF0758_4879 | HMPREF0758_2828 | Flavodoxin; Low-potential electron donor to a number of redox enzymes. Belongs to the flavodoxin family. | Ribonucleoside-diphosphate reductase, beta subunit; COG: COG0208; Pfam: PF00268; InterPro: IPR012348. | 0.419 |
| fldA3 | seqA | HMPREF0758_4879 | HMPREF0758_4875 | Flavodoxin; Low-potential electron donor to a number of redox enzymes. Belongs to the flavodoxin family. | SeqA protein; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. | 0.528 |
| fldA3 | ybfE | HMPREF0758_4879 | HMPREF0758_4878 | Flavodoxin; Low-potential electron donor to a number of redox enzymes. Belongs to the flavodoxin family. | Ribbon-helix-helix protein, CopG family; Pfam: PF01402. | 0.568 |
| fur | fldA3 | HMPREF0758_4880 | HMPREF0758_4879 | Transcriptional regulator, Fur family; COG: COG0735; Pfam: PF01475; InterPro: IPR002481; Belongs to the Fur family. | Flavodoxin; Low-potential electron donor to a number of redox enzymes. Belongs to the flavodoxin family. | 0.639 |
| nifJ | fldA3 | HMPREF0758_3621 | HMPREF0758_4879 | Pyruvate synthase; COG: COG0674; Pfam: PF01855,PF01558,PF00037,PF02775; InterPro: IPR011895. | Flavodoxin; Low-potential electron donor to a number of redox enzymes. Belongs to the flavodoxin family. | 0.630 |
| nrdA | fldA3 | HMPREF0758_2829 | HMPREF0758_4879 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Flavodoxin; Low-potential electron donor to a number of redox enzymes. Belongs to the flavodoxin family. | 0.408 |
| nrdA | nrdB | HMPREF0758_2829 | HMPREF0758_2828 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Ribonucleoside-diphosphate reductase, beta subunit; COG: COG0208; Pfam: PF00268; InterPro: IPR012348. | 0.998 |
| nrdB | fldA3 | HMPREF0758_2828 | HMPREF0758_4879 | Ribonucleoside-diphosphate reductase, beta subunit; COG: COG0208; Pfam: PF00268; InterPro: IPR012348. | Flavodoxin; Low-potential electron donor to a number of redox enzymes. Belongs to the flavodoxin family. | 0.419 |
| nrdB | nrdA | HMPREF0758_2828 | HMPREF0758_2829 | Ribonucleoside-diphosphate reductase, beta subunit; COG: COG0208; Pfam: PF00268; InterPro: IPR012348. | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.998 |
| seqA | fldA3 | HMPREF0758_4875 | HMPREF0758_4879 | SeqA protein; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. | Flavodoxin; Low-potential electron donor to a number of redox enzymes. Belongs to the flavodoxin family. | 0.528 |
| seqA | ybfE | HMPREF0758_4875 | HMPREF0758_4878 | SeqA protein; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. | Ribbon-helix-helix protein, CopG family; Pfam: PF01402. | 0.716 |
| ybfE | fldA3 | HMPREF0758_4878 | HMPREF0758_4879 | Ribbon-helix-helix protein, CopG family; Pfam: PF01402. | Flavodoxin; Low-potential electron donor to a number of redox enzymes. Belongs to the flavodoxin family. | 0.568 |
| ybfE | seqA | HMPREF0758_4878 | HMPREF0758_4875 | Ribbon-helix-helix protein, CopG family; Pfam: PF01402. | SeqA protein; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. | 0.716 |