| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| YbeD | phoL | HMPREF0758_4920 | HMPREF0758_4899 | Hypothetical protein; COG: COG2921; Pfam: PF04359; InterPro: IPR007454; Belongs to the UPF0250 family. | PhoH family protein; COG: COG1702; Pfam: PF02562; InterPro: IPR003714. | 0.404 |
| clpX | phoL | HMPREF0758_0200 | HMPREF0758_4899 | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | PhoH family protein; COG: COG1702; Pfam: PF02562; InterPro: IPR003714. | 0.627 |
| corC | lnt | HMPREF0758_4901 | HMPREF0758_4902 | CBS domain protein; COG: COG4535; Pfam: PF00571,PF03471; InterPro: IPR000644. | Apolipoprotein N-acyltransferase; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation; Belongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily. | 0.865 |
| corC | phoL | HMPREF0758_4901 | HMPREF0758_4899 | CBS domain protein; COG: COG4535; Pfam: PF00571,PF03471; InterPro: IPR000644. | PhoH family protein; COG: COG1702; Pfam: PF02562; InterPro: IPR003714. | 0.746 |
| corC | ybeY | HMPREF0758_4901 | HMPREF0758_4900 | CBS domain protein; COG: COG4535; Pfam: PF00571,PF03471; InterPro: IPR000644. | Translation metalloprotein YbeY; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. | 0.859 |
| era | phoL | HMPREF0758_2456 | HMPREF0758_4899 | Ribosome biogenesis GTPase Era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. | PhoH family protein; COG: COG1702; Pfam: PF02562; InterPro: IPR003714. | 0.410 |
| era | recO | HMPREF0758_2456 | HMPREF0758_2457 | Ribosome biogenesis GTPase Era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. | DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. | 0.930 |
| era | rimP | HMPREF0758_2456 | HMPREF0758_0806 | Ribosome biogenesis GTPase Era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. | Hypothetical protein; Required for maturation of 30S ribosomal subunits. Belongs to the RimP family. | 0.531 |
| era | sun | HMPREF0758_2456 | HMPREF0758_0930 | Ribosome biogenesis GTPase Era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. | Ribosomal RNA small subunit methyltransferase B; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.602 |
| era | ybeY | HMPREF0758_2456 | HMPREF0758_4900 | Ribosome biogenesis GTPase Era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. | Translation metalloprotein YbeY; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. | 0.839 |
| lnt | corC | HMPREF0758_4902 | HMPREF0758_4901 | Apolipoprotein N-acyltransferase; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation; Belongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily. | CBS domain protein; COG: COG4535; Pfam: PF00571,PF03471; InterPro: IPR000644. | 0.865 |
| lnt | phoL | HMPREF0758_4902 | HMPREF0758_4899 | Apolipoprotein N-acyltransferase; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation; Belongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily. | PhoH family protein; COG: COG1702; Pfam: PF02562; InterPro: IPR003714. | 0.870 |
| lnt | ybeY | HMPREF0758_4902 | HMPREF0758_4900 | Apolipoprotein N-acyltransferase; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation; Belongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily. | Translation metalloprotein YbeY; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. | 0.700 |
| phoL | YbeD | HMPREF0758_4899 | HMPREF0758_4920 | PhoH family protein; COG: COG1702; Pfam: PF02562; InterPro: IPR003714. | Hypothetical protein; COG: COG2921; Pfam: PF04359; InterPro: IPR007454; Belongs to the UPF0250 family. | 0.404 |
| phoL | clpX | HMPREF0758_4899 | HMPREF0758_0200 | PhoH family protein; COG: COG1702; Pfam: PF02562; InterPro: IPR003714. | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.627 |
| phoL | corC | HMPREF0758_4899 | HMPREF0758_4901 | PhoH family protein; COG: COG1702; Pfam: PF02562; InterPro: IPR003714. | CBS domain protein; COG: COG4535; Pfam: PF00571,PF03471; InterPro: IPR000644. | 0.746 |
| phoL | era | HMPREF0758_4899 | HMPREF0758_2456 | PhoH family protein; COG: COG1702; Pfam: PF02562; InterPro: IPR003714. | Ribosome biogenesis GTPase Era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. | 0.410 |
| phoL | lnt | HMPREF0758_4899 | HMPREF0758_4902 | PhoH family protein; COG: COG1702; Pfam: PF02562; InterPro: IPR003714. | Apolipoprotein N-acyltransferase; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation; Belongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily. | 0.870 |
| phoL | recO | HMPREF0758_4899 | HMPREF0758_2457 | PhoH family protein; COG: COG1702; Pfam: PF02562; InterPro: IPR003714. | DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. | 0.664 |
| phoL | rimP | HMPREF0758_4899 | HMPREF0758_0806 | PhoH family protein; COG: COG1702; Pfam: PF02562; InterPro: IPR003714. | Hypothetical protein; Required for maturation of 30S ribosomal subunits. Belongs to the RimP family. | 0.409 |