| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| dacA3 | mrdA-3 | HMPREF0758_4919 | HMPREF0758_4916 | Serine-type D-Ala-D-Ala carboxypeptidase; COG: COG1686; Pfam: PF00768,PF07943; InterPro: IPR001967; Belongs to the peptidase S11 family. | Penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. | 0.696 |
| dacA3 | mrdB | HMPREF0758_4919 | HMPREF0758_4917 | Serine-type D-Ala-D-Ala carboxypeptidase; COG: COG1686; Pfam: PF00768,PF07943; InterPro: IPR001967; Belongs to the peptidase S11 family. | Rod shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. | 0.679 |
| dacA3 | mreC | HMPREF0758_4919 | HMPREF0758_1816 | Serine-type D-Ala-D-Ala carboxypeptidase; COG: COG1686; Pfam: PF00768,PF07943; InterPro: IPR001967; Belongs to the peptidase S11 family. | Rod shape-determining protein MreC; Involved in formation and maintenance of cell shape. | 0.471 |
| dacA3 | rlmH | HMPREF0758_4919 | HMPREF0758_4915 | Serine-type D-Ala-D-Ala carboxypeptidase; COG: COG1686; Pfam: PF00768,PF07943; InterPro: IPR001967; Belongs to the peptidase S11 family. | rRNA large subunit m3Psi methyltransferase RlmH; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family. | 0.639 |
| dacA3 | rlpA | HMPREF0758_4919 | HMPREF0758_4918 | Serine-type D-Ala-D-Ala carboxypeptidase; COG: COG1686; Pfam: PF00768,PF07943; InterPro: IPR001967; Belongs to the peptidase S11 family. | Sporulation and cell division repeat protein; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. | 0.615 |
| ftsQ | ftsW | HMPREF0758_0510 | HMPREF0758_0514 | Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. | Cell division protein FtsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. | 0.967 |
| ftsQ | mrdA-2 | HMPREF0758_0510 | HMPREF0758_3673 | Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. | Penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. | 0.707 |
| ftsQ | mrdA-3 | HMPREF0758_0510 | HMPREF0758_4916 | Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. | Penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. | 0.707 |
| ftsQ | mrdB | HMPREF0758_0510 | HMPREF0758_4917 | Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. | Rod shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. | 0.785 |
| ftsQ | mreC | HMPREF0758_0510 | HMPREF0758_1816 | Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. | Rod shape-determining protein MreC; Involved in formation and maintenance of cell shape. | 0.532 |
| ftsW | ftsQ | HMPREF0758_0514 | HMPREF0758_0510 | Cell division protein FtsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. | Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. | 0.967 |
| ftsW | mrcB | HMPREF0758_0514 | HMPREF0758_2168 | Cell division protein FtsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. | Penicillin-binding protein 1B; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). | 0.655 |
| ftsW | mrdA-2 | HMPREF0758_0514 | HMPREF0758_3673 | Cell division protein FtsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. | Penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. | 0.850 |
| ftsW | mrdA-3 | HMPREF0758_0514 | HMPREF0758_4916 | Cell division protein FtsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. | Penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. | 0.875 |
| ftsW | mrdB | HMPREF0758_0514 | HMPREF0758_4917 | Cell division protein FtsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. | Rod shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. | 0.410 |
| ftsW | mreB | HMPREF0758_0514 | HMPREF0758_1815 | Cell division protein FtsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. | Rod shape-determining protein MreB; COG: COG1077; Pfam: PF06723; InterPro: IPR004753. | 0.814 |
| ftsW | mreC | HMPREF0758_0514 | HMPREF0758_1816 | Cell division protein FtsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. | Rod shape-determining protein MreC; Involved in formation and maintenance of cell shape. | 0.617 |
| mrcB | ftsW | HMPREF0758_2168 | HMPREF0758_0514 | Penicillin-binding protein 1B; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). | Cell division protein FtsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. | 0.655 |
| mrcB | mrdA-2 | HMPREF0758_2168 | HMPREF0758_3673 | Penicillin-binding protein 1B; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). | Penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. | 0.734 |
| mrcB | mrdA-3 | HMPREF0758_2168 | HMPREF0758_4916 | Penicillin-binding protein 1B; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). | Penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. | 0.758 |