| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ftsI | ftsI2 | HMPREF0758_0520 | HMPREF0758_3674 | Penicillin-binding protein dimerization domain protein; COG: COG0768; Pfam: PF03717,PF00905; InterPro: IPR005311. | Penicillin-binding protein, transpeptidase domain protein; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum. | 0.908 |
| ftsI | mrdB | HMPREF0758_0520 | HMPREF0758_4917 | Penicillin-binding protein dimerization domain protein; COG: COG0768; Pfam: PF03717,PF00905; InterPro: IPR005311. | Rod shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. | 0.855 |
| ftsI | mreB | HMPREF0758_0520 | HMPREF0758_1815 | Penicillin-binding protein dimerization domain protein; COG: COG0768; Pfam: PF03717,PF00905; InterPro: IPR005311. | Rod shape-determining protein MreB; COG: COG1077; Pfam: PF06723; InterPro: IPR004753. | 0.547 |
| ftsI | murA | HMPREF0758_0520 | HMPREF0758_1866 | Penicillin-binding protein dimerization domain protein; COG: COG0768; Pfam: PF03717,PF00905; InterPro: IPR005311. | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.648 |
| ftsI | murC | HMPREF0758_0520 | HMPREF0758_0512 | Penicillin-binding protein dimerization domain protein; COG: COG0768; Pfam: PF03717,PF00905; InterPro: IPR005311. | UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.860 |
| ftsI | murD | HMPREF0758_0520 | HMPREF0758_0515 | Penicillin-binding protein dimerization domain protein; COG: COG0768; Pfam: PF03717,PF00905; InterPro: IPR005311. | UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.871 |
| ftsI | murF | HMPREF0758_0520 | HMPREF0758_0517 | Penicillin-binding protein dimerization domain protein; COG: COG0768; Pfam: PF03717,PF00905; InterPro: IPR005311. | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. | 0.903 |
| ftsI | murG | HMPREF0758_0520 | HMPREF0758_0513 | Penicillin-binding protein dimerization domain protein; COG: COG0768; Pfam: PF03717,PF00905; InterPro: IPR005311. | Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.859 |
| ftsI2 | ftsI | HMPREF0758_3674 | HMPREF0758_0520 | Penicillin-binding protein, transpeptidase domain protein; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum. | Penicillin-binding protein dimerization domain protein; COG: COG0768; Pfam: PF03717,PF00905; InterPro: IPR005311. | 0.908 |
| ftsI2 | mrdA-2 | HMPREF0758_3674 | HMPREF0758_3673 | Penicillin-binding protein, transpeptidase domain protein; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum. | Penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. | 0.615 |
| ftsI2 | mrdB | HMPREF0758_3674 | HMPREF0758_4917 | Penicillin-binding protein, transpeptidase domain protein; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum. | Rod shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. | 0.862 |
| ftsI2 | mreB | HMPREF0758_3674 | HMPREF0758_1815 | Penicillin-binding protein, transpeptidase domain protein; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum. | Rod shape-determining protein MreB; COG: COG1077; Pfam: PF06723; InterPro: IPR004753. | 0.610 |
| ftsI2 | murA | HMPREF0758_3674 | HMPREF0758_1866 | Penicillin-binding protein, transpeptidase domain protein; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum. | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.575 |
| ftsI2 | murC | HMPREF0758_3674 | HMPREF0758_0512 | Penicillin-binding protein, transpeptidase domain protein; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum. | UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.780 |
| ftsI2 | murD | HMPREF0758_3674 | HMPREF0758_0515 | Penicillin-binding protein, transpeptidase domain protein; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum. | UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.743 |
| ftsI2 | murF | HMPREF0758_3674 | HMPREF0758_0517 | Penicillin-binding protein, transpeptidase domain protein; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum. | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. | 0.771 |
| ftsI2 | murG | HMPREF0758_3674 | HMPREF0758_0513 | Penicillin-binding protein, transpeptidase domain protein; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum. | Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.725 |
| mrdA-2 | ftsI2 | HMPREF0758_3673 | HMPREF0758_3674 | Penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. | Penicillin-binding protein, transpeptidase domain protein; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum. | 0.615 |
| mrdA-2 | mrdA-3 | HMPREF0758_3673 | HMPREF0758_4916 | Penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. | Penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. | 0.902 |
| mrdA-2 | mrdB | HMPREF0758_3673 | HMPREF0758_4917 | Penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. | Rod shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. | 0.939 |