| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| amiB | holA | HMPREF0758_0868 | HMPREF0758_4912 | N-acetylmuramoyl-L-alanine amidase; COG: COG0860; Pfam: PF01520,PF01476; InterPro: IPR002508. | DNA polymerase III, delta subunit; COG: COG1466; Pfam: PF06144; InterPro: IPR005790. | 0.400 |
| amiB | mrdA-3 | HMPREF0758_0868 | HMPREF0758_4916 | N-acetylmuramoyl-L-alanine amidase; COG: COG0860; Pfam: PF01520,PF01476; InterPro: IPR002508. | Penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. | 0.498 |
| amiB | mrdB | HMPREF0758_0868 | HMPREF0758_4917 | N-acetylmuramoyl-L-alanine amidase; COG: COG0860; Pfam: PF01520,PF01476; InterPro: IPR002508. | Rod shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. | 0.597 |
| amiB | rlpA | HMPREF0758_0868 | HMPREF0758_4918 | N-acetylmuramoyl-L-alanine amidase; COG: COG0860; Pfam: PF01520,PF01476; InterPro: IPR002508. | Sporulation and cell division repeat protein; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. | 0.571 |
| dacA3 | holA | HMPREF0758_4919 | HMPREF0758_4912 | Serine-type D-Ala-D-Ala carboxypeptidase; COG: COG1686; Pfam: PF00768,PF07943; InterPro: IPR001967; Belongs to the peptidase S11 family. | DNA polymerase III, delta subunit; COG: COG1466; Pfam: PF06144; InterPro: IPR005790. | 0.410 |
| dacA3 | lptE | HMPREF0758_4919 | HMPREF0758_4911 | Serine-type D-Ala-D-Ala carboxypeptidase; COG: COG1686; Pfam: PF00768,PF07943; InterPro: IPR001967; Belongs to the peptidase S11 family. | Rare lipoprotein B family protein; Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane. | 0.441 |
| dacA3 | mrdA-3 | HMPREF0758_4919 | HMPREF0758_4916 | Serine-type D-Ala-D-Ala carboxypeptidase; COG: COG1686; Pfam: PF00768,PF07943; InterPro: IPR001967; Belongs to the peptidase S11 family. | Penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. | 0.696 |
| dacA3 | mrdB | HMPREF0758_4919 | HMPREF0758_4917 | Serine-type D-Ala-D-Ala carboxypeptidase; COG: COG1686; Pfam: PF00768,PF07943; InterPro: IPR001967; Belongs to the peptidase S11 family. | Rod shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. | 0.679 |
| dacA3 | nadD | HMPREF0758_4919 | HMPREF0758_4913 | Serine-type D-Ala-D-Ala carboxypeptidase; COG: COG1686; Pfam: PF00768,PF07943; InterPro: IPR001967; Belongs to the peptidase S11 family. | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.410 |
| dacA3 | rlmH | HMPREF0758_4919 | HMPREF0758_4915 | Serine-type D-Ala-D-Ala carboxypeptidase; COG: COG1686; Pfam: PF00768,PF07943; InterPro: IPR001967; Belongs to the peptidase S11 family. | rRNA large subunit m3Psi methyltransferase RlmH; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family. | 0.639 |
| dacA3 | rlpA | HMPREF0758_4919 | HMPREF0758_4918 | Serine-type D-Ala-D-Ala carboxypeptidase; COG: COG1686; Pfam: PF00768,PF07943; InterPro: IPR001967; Belongs to the peptidase S11 family. | Sporulation and cell division repeat protein; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. | 0.615 |
| dacA3 | ybeB | HMPREF0758_4919 | HMPREF0758_4914 | Serine-type D-Ala-D-Ala carboxypeptidase; COG: COG1686; Pfam: PF00768,PF07943; InterPro: IPR001967; Belongs to the peptidase S11 family. | Iojap-like protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. | 0.524 |
| holA | amiB | HMPREF0758_4912 | HMPREF0758_0868 | DNA polymerase III, delta subunit; COG: COG1466; Pfam: PF06144; InterPro: IPR005790. | N-acetylmuramoyl-L-alanine amidase; COG: COG0860; Pfam: PF01520,PF01476; InterPro: IPR002508. | 0.400 |
| holA | dacA3 | HMPREF0758_4912 | HMPREF0758_4919 | DNA polymerase III, delta subunit; COG: COG1466; Pfam: PF06144; InterPro: IPR005790. | Serine-type D-Ala-D-Ala carboxypeptidase; COG: COG1686; Pfam: PF00768,PF07943; InterPro: IPR001967; Belongs to the peptidase S11 family. | 0.410 |
| holA | lptE | HMPREF0758_4912 | HMPREF0758_4911 | DNA polymerase III, delta subunit; COG: COG1466; Pfam: PF06144; InterPro: IPR005790. | Rare lipoprotein B family protein; Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane. | 0.862 |
| holA | mrdA-3 | HMPREF0758_4912 | HMPREF0758_4916 | DNA polymerase III, delta subunit; COG: COG1466; Pfam: PF06144; InterPro: IPR005790. | Penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. | 0.621 |
| holA | mrdB | HMPREF0758_4912 | HMPREF0758_4917 | DNA polymerase III, delta subunit; COG: COG1466; Pfam: PF06144; InterPro: IPR005790. | Rod shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. | 0.619 |
| holA | nadD | HMPREF0758_4912 | HMPREF0758_4913 | DNA polymerase III, delta subunit; COG: COG1466; Pfam: PF06144; InterPro: IPR005790. | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.817 |
| holA | rlmH | HMPREF0758_4912 | HMPREF0758_4915 | DNA polymerase III, delta subunit; COG: COG1466; Pfam: PF06144; InterPro: IPR005790. | rRNA large subunit m3Psi methyltransferase RlmH; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family. | 0.693 |
| holA | rlpA | HMPREF0758_4912 | HMPREF0758_4918 | DNA polymerase III, delta subunit; COG: COG1466; Pfam: PF06144; InterPro: IPR005790. | Sporulation and cell division repeat protein; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. | 0.557 |