| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cysB2 | parB | HMPREF0758_4525 | HMPREF0758_4965 | Putative cystathionine beta-synthase; COG: COG0031; Pfam: PF00291,PF00571; InterPro: IPR001926. | ParB-like protein; COG: COG1475; Pfam: PF02195,PF08775; InterPro: IPR004437. | 0.421 |
| cysB2 | relE | HMPREF0758_4525 | HMPREF0758_4968 | Putative cystathionine beta-synthase; COG: COG0031; Pfam: PF00291,PF00571; InterPro: IPR001926. | Toxin RelE; COG: COG2026; Pfam: PF05016; InterPro: IPR012753. | 0.418 |
| macB | relE | HMPREF0758_4460 | HMPREF0758_4968 | ABC transporter, ATP-binding protein; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. | Toxin RelE; COG: COG2026; Pfam: PF05016; InterPro: IPR012753. | 0.538 |
| mck | relE | HMPREF0758_4972 | HMPREF0758_4968 | PIN domain protein; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family. | Toxin RelE; COG: COG2026; Pfam: PF05016; InterPro: IPR012753. | 0.414 |
| parA | parB | HMPREF0758_4966 | HMPREF0758_4965 | Plasmid partition protein A; COG: COG1192. | ParB-like protein; COG: COG1475; Pfam: PF02195,PF08775; InterPro: IPR004437. | 0.930 |
| parA | relB | HMPREF0758_4966 | HMPREF0758_4967 | Plasmid partition protein A; COG: COG1192. | Antitoxin RelB; Pfam: PF04221; InterPro: IPR007337. | 0.479 |
| parA | relE | HMPREF0758_4966 | HMPREF0758_4968 | Plasmid partition protein A; COG: COG1192. | Toxin RelE; COG: COG2026; Pfam: PF05016; InterPro: IPR012753. | 0.479 |
| parB | cysB2 | HMPREF0758_4965 | HMPREF0758_4525 | ParB-like protein; COG: COG1475; Pfam: PF02195,PF08775; InterPro: IPR004437. | Putative cystathionine beta-synthase; COG: COG0031; Pfam: PF00291,PF00571; InterPro: IPR001926. | 0.421 |
| parB | parA | HMPREF0758_4965 | HMPREF0758_4966 | ParB-like protein; COG: COG1475; Pfam: PF02195,PF08775; InterPro: IPR004437. | Plasmid partition protein A; COG: COG1192. | 0.930 |
| parB | relB | HMPREF0758_4965 | HMPREF0758_4967 | ParB-like protein; COG: COG1475; Pfam: PF02195,PF08775; InterPro: IPR004437. | Antitoxin RelB; Pfam: PF04221; InterPro: IPR007337. | 0.479 |
| parB | relE | HMPREF0758_4965 | HMPREF0758_4968 | ParB-like protein; COG: COG1475; Pfam: PF02195,PF08775; InterPro: IPR004437. | Toxin RelE; COG: COG2026; Pfam: PF05016; InterPro: IPR012753. | 0.479 |
| relB | parA | HMPREF0758_4967 | HMPREF0758_4966 | Antitoxin RelB; Pfam: PF04221; InterPro: IPR007337. | Plasmid partition protein A; COG: COG1192. | 0.479 |
| relB | parB | HMPREF0758_4967 | HMPREF0758_4965 | Antitoxin RelB; Pfam: PF04221; InterPro: IPR007337. | ParB-like protein; COG: COG1475; Pfam: PF02195,PF08775; InterPro: IPR004437. | 0.479 |
| relB | relE | HMPREF0758_4967 | HMPREF0758_4968 | Antitoxin RelB; Pfam: PF04221; InterPro: IPR007337. | Toxin RelE; COG: COG2026; Pfam: PF05016; InterPro: IPR012753. | 0.991 |
| relE | cysB2 | HMPREF0758_4968 | HMPREF0758_4525 | Toxin RelE; COG: COG2026; Pfam: PF05016; InterPro: IPR012753. | Putative cystathionine beta-synthase; COG: COG0031; Pfam: PF00291,PF00571; InterPro: IPR001926. | 0.418 |
| relE | macB | HMPREF0758_4968 | HMPREF0758_4460 | Toxin RelE; COG: COG2026; Pfam: PF05016; InterPro: IPR012753. | ABC transporter, ATP-binding protein; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. | 0.538 |
| relE | mck | HMPREF0758_4968 | HMPREF0758_4972 | Toxin RelE; COG: COG2026; Pfam: PF05016; InterPro: IPR012753. | PIN domain protein; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family. | 0.414 |
| relE | parA | HMPREF0758_4968 | HMPREF0758_4966 | Toxin RelE; COG: COG2026; Pfam: PF05016; InterPro: IPR012753. | Plasmid partition protein A; COG: COG1192. | 0.479 |
| relE | parB | HMPREF0758_4968 | HMPREF0758_4965 | Toxin RelE; COG: COG2026; Pfam: PF05016; InterPro: IPR012753. | ParB-like protein; COG: COG1475; Pfam: PF02195,PF08775; InterPro: IPR004437. | 0.479 |
| relE | relB | HMPREF0758_4968 | HMPREF0758_4967 | Toxin RelE; COG: COG2026; Pfam: PF05016; InterPro: IPR012753. | Antitoxin RelB; Pfam: PF04221; InterPro: IPR007337. | 0.991 |