SARC_13980 protein (Sphaeroforma arctica) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

SARC_13980

Ras-GEF domain-containing protein. (90 aa)

Predicted Functional Partners:

SARC_14707

0.808

SARC_12964

0.808

SARC_01807

0.790

SARC_11875

0.711

SARC_12904

0.700

SARC_13436

0.690

SARC_10792

0.690

SARC_07145

0.690

SARC_03842

0.690

SARC_02592

0.690

Your Current Organism:

Sphaeroforma arctica

NCBI taxonomy Id: 667725
Other names: S. arctica JP610, Sphaeroforma arctica JP610

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SARC_01807	SARC_02592	A0A0L0GAT1	A0A0L0G8K9	Uncharacterized protein.	TK protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.838
SARC_01807	SARC_03842	A0A0L0GAT1	A0A0L0G4A0	Uncharacterized protein.	TK protein kinase.	0.838
SARC_01807	SARC_07145	A0A0L0GAT1	A0A0L0FX16	Uncharacterized protein.	TK protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.838
SARC_01807	SARC_10792	A0A0L0GAT1	A0A0L0FIZ4	Uncharacterized protein.	TK protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.838
SARC_01807	SARC_11875	A0A0L0GAT1	A0A0L0FFU0	Uncharacterized protein.	Septum-promoting GTP-binding protein 1.	0.413
SARC_01807	SARC_12904	A0A0L0GAT1	A0A0L0FCS2	Uncharacterized protein.	Protein kinase domain-containing protein.	0.935
SARC_01807	SARC_12964	A0A0L0GAT1	A0A0L0FCJ1	Uncharacterized protein.	SH2 domain-containing protein.	0.973
SARC_01807	SARC_13436	A0A0L0GAT1	A0A0L0FBY4	Uncharacterized protein.	Serine/threonine protein kinase.	0.838
SARC_01807	SARC_13980	A0A0L0GAT1	A0A0L0F9Q6	Uncharacterized protein.	Ras-GEF domain-containing protein.	0.790
SARC_01807	SARC_14707	A0A0L0GAT1	A0A0L0F7M0	Uncharacterized protein.	SH3 domain-containing protein.	0.973
SARC_02592	SARC_01807	A0A0L0G8K9	A0A0L0GAT1	TK protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Uncharacterized protein.	0.838
SARC_02592	SARC_03842	A0A0L0G8K9	A0A0L0G4A0	TK protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family.	TK protein kinase.	0.772
SARC_02592	SARC_07145	A0A0L0G8K9	A0A0L0FX16	TK protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family.	TK protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.772
SARC_02592	SARC_10792	A0A0L0G8K9	A0A0L0FIZ4	TK protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family.	TK protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.752
SARC_02592	SARC_11875	A0A0L0G8K9	A0A0L0FFU0	TK protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Septum-promoting GTP-binding protein 1.	0.848
SARC_02592	SARC_12904	A0A0L0G8K9	A0A0L0FCS2	TK protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Protein kinase domain-containing protein.	0.793
SARC_02592	SARC_12964	A0A0L0G8K9	A0A0L0FCJ1	TK protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family.	SH2 domain-containing protein.	0.958
SARC_02592	SARC_13436	A0A0L0G8K9	A0A0L0FBY4	TK protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Serine/threonine protein kinase.	0.752
SARC_02592	SARC_13980	A0A0L0G8K9	A0A0L0F9Q6	TK protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Ras-GEF domain-containing protein.	0.690
SARC_02592	SARC_14707	A0A0L0G8K9	A0A0L0F7M0	TK protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family.	SH3 domain-containing protein.	0.958

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

35

average node degree:

6.36

avg. local clustering coefficient:

0.785

expected number of edges:

11

PPI enrichment p-value:

2.36e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006913

Nucleocytoplasmic transport

11 of 89

1.88

5.41

1.47e-17

GO:0034504

Protein localization to nucleus

7 of 37

2.06

4.49

3.60e-11

GO:0050658

RNA transport

8 of 57

1.93

4.33

8.50e-12

GO:0051028

mRNA transport

7 of 45

1.98

4.14

1.03e-10

GO:0006606

Protein import into nucleus

6 of 30

2.08

3.98

1.47e-09

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0017056

Structural constituent of nuclear pore

10 of 17

2.55

9.67

2.47e-21

GO:0005198

Structural molecule activity

11 of 192

1.54

3.37

1.01e-14

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005643

Nuclear pore

11 of 30

2.35

9.31

7.87e-23

GO:0031080

Nuclear pore outer ring

4 of 4

2.78

4.04

2.93e-08

GO:0031965

Nuclear membrane

4 of 27

1.95

2.36

1.01e-05

GO:0044611

Nuclear pore inner ring

2 of 3

2.61

1.51

0.0017

GO:0044613

Nuclear pore central transport channel

2 of 4

2.48

1.43

0.0023

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2262

Structural constituent of nuclear pore

10 of 16

2.58

9.87

1.34e-21

CL:2264

Structural constituent of nuclear pore

8 of 10

2.69

8.47

1.22e-17

CL:2274

Nuclear pore outer ring, and Nuclear matrix

4 of 5

2.69

3.83

6.25e-08

CL:2265

Nuclear pore inner ring, and NLS-bearing protein import into nucleus

4 of 5

2.69

3.83

6.25e-08

CL:2284

Nuclear RNA export factor complex, and Structural constituent of nuclear pore

2 of 5

2.39

1.23

0.0053

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03013

RNA transport

11 of 127

1.72

4.55

2.72e-17

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-4085377

SUMOylation of SUMOylation proteins

10 of 25

2.39

8.59

3.66e-20

MAP-5578749

Transcriptional regulation by small RNAs

9 of 22

2.4

7.81

6.70e-18

MAP-159227

Transport of the SLBP independent Mature mRNA

9 of 23

2.38

7.75

6.70e-18

MAP-159234

Transport of Mature mRNAs Derived from Intronless Transcripts

9 of 24

2.36

7.68

6.70e-18

MAP-159231

Transport of Mature mRNA Derived from an Intronless Transcript

9 of 24

2.36

7.68

6.70e-18

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005643

Nuclear pore

10 of 35

2.24

7.58

5.49e-19

GOCC:0005635

Nuclear envelope

11 of 73

1.96

6.16

5.49e-19

GOCC:0044611

Nuclear pore inner ring

2 of 2

2.78

1.57

0.0014

GOCC:0031080

Nuclear pore outer ring

2 of 2

2.78

1.57

0.0014

GOCC:0044613

Nuclear pore central transport channel

2 of 4

2.48

1.39

0.0027

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0906

Nuclear pore complex

3 of 5

2.56

2.37

3.93e-05

KW-0509

mRNA transport

3 of 5

2.56

2.37

3.93e-05

KW-0653

Protein transport

4 of 57

1.63

1.69

0.00011

KW-0175

Coiled coil

6 of 750

0.69

0.44

0.0203

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF08801

Nup133 N terminal like

2 of 2

2.78

1.08

0.0109

PF03177

Non-repetitive/WGA-negative nucleoporin C-terminal

2 of 2

2.78

1.08

0.0109

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR014908

Nucleoporin, Nup133/Nup155-like, N-terminal

2 of 2

2.78

0.83

0.0322

IPR007187

Nucleoporin, Nup133/Nup155-like, C-terminal

2 of 2

2.78

0.83

0.0322

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (22%) [HD]

Permalink

Credits

Access

Info

About

STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About