SARC_12541 protein (Sphaeroforma arctica) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

SARC_12541

PMT_4TMC domain-containing protein. (167 aa)

Predicted Functional Partners:

SARC_15454

0.649

SARC_11818

0.533

SARC_14762

0.461

SARC_05901

0.449

SARC_09222

0.433

SARC_06505

0.433

SARC_02633

0.432

SARC_00241

0.432

Your Current Organism:

Sphaeroforma arctica

NCBI taxonomy Id: 667725
Other names: S. arctica JP610, Sphaeroforma arctica JP610

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SARC_00241	SARC_05901	A0A0L0GF55	A0A0L0FZ03	Uncharacterized protein.	Uncharacterized protein.	0.432
SARC_00241	SARC_12541	A0A0L0GF55	A0A0L0FDS8	Uncharacterized protein.	PMT_4TMC domain-containing protein.	0.432
SARC_00241	SARC_14762	A0A0L0GF55	A0A0L0F7G2	Uncharacterized protein.	Uncharacterized protein.	0.432
SARC_00241	SARC_15454	A0A0L0GF55	A0A0L0F5K6	Uncharacterized protein.	Uncharacterized protein.	0.708
SARC_02633	SARC_05901	A0A0L0G8H4	A0A0L0FZ03	Uncharacterized protein.	Uncharacterized protein.	0.432
SARC_02633	SARC_12541	A0A0L0G8H4	A0A0L0FDS8	Uncharacterized protein.	PMT_4TMC domain-containing protein.	0.432
SARC_02633	SARC_14762	A0A0L0G8H4	A0A0L0F7G2	Uncharacterized protein.	Uncharacterized protein.	0.432
SARC_02633	SARC_15454	A0A0L0G8H4	A0A0L0F5K6	Uncharacterized protein.	Uncharacterized protein.	0.708
SARC_05901	SARC_00241	A0A0L0FZ03	A0A0L0GF55	Uncharacterized protein.	Uncharacterized protein.	0.432
SARC_05901	SARC_02633	A0A0L0FZ03	A0A0L0G8H4	Uncharacterized protein.	Uncharacterized protein.	0.432
SARC_05901	SARC_06505	A0A0L0FZ03	A0A0L0FYX5	Uncharacterized protein.	Uncharacterized protein.	0.433
SARC_05901	SARC_09222	A0A0L0FZ03	A0A0L0FQQ0	Uncharacterized protein.	Uncharacterized protein.	0.433
SARC_05901	SARC_11818	A0A0L0FZ03	A0A0L0FFW0	Uncharacterized protein.	GPI mannosyltransferase 2; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis.	0.533
SARC_05901	SARC_12541	A0A0L0FZ03	A0A0L0FDS8	Uncharacterized protein.	PMT_4TMC domain-containing protein.	0.449
SARC_05901	SARC_15454	A0A0L0FZ03	A0A0L0F5K6	Uncharacterized protein.	Uncharacterized protein.	0.649
SARC_06505	SARC_05901	A0A0L0FYX5	A0A0L0FZ03	Uncharacterized protein.	Uncharacterized protein.	0.433
SARC_06505	SARC_12541	A0A0L0FYX5	A0A0L0FDS8	Uncharacterized protein.	PMT_4TMC domain-containing protein.	0.433
SARC_06505	SARC_14762	A0A0L0FYX5	A0A0L0F7G2	Uncharacterized protein.	Uncharacterized protein.	0.433
SARC_06505	SARC_15454	A0A0L0FYX5	A0A0L0F5K6	Uncharacterized protein.	Uncharacterized protein.	0.708
SARC_09222	SARC_05901	A0A0L0FQQ0	A0A0L0FZ03	Uncharacterized protein.	Uncharacterized protein.	0.433

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

41

average node degree:

7.45

avg. local clustering coefficient:

0.909

expected number of edges:

26

PPI enrichment p-value:

0.00345

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006091

Generation of precursor metabolites and energy

6 of 126

1.06

0.76

0.0060

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051536

Iron-sulfur cluster binding

6 of 75

1.28

1.27

0.00018

GO:0051539

4 iron, 4 sulfur cluster binding

4 of 37

1.41

1.06

0.0032

GO:0005506

Iron ion binding

3 of 24

1.47

0.81

0.0188

GO:0016491

Oxidoreductase activity

7 of 244

0.84

0.63

0.0032

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:471

Tricarboxylic acid cycle, and 4Fe-4S binding domain

5 of 11

2.04

3.17

1.37e-07

CL:467

Mixed, incl. Citrate cycle (TCA cycle), and acetyl-CoA metabolic process

7 of 40

1.62

2.72

1.33e-08

CL:468

Citrate cycle (TCA cycle), and Alpha-helical ferredoxin

6 of 28

1.71

2.69

1.07e-07

CL:462

Mixed, incl. Oxidative phosphorylation, and Carbon metabolism

10 of 118

1.31

2.09

3.19e-10

CL:473

Tricarboxylic acid cycle

2 of 5

1.98

0.94

0.0161

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00620

Pyruvate metabolism

4 of 32

1.47

1.26

0.0010

map00020

Citrate cycle (TCA cycle)

3 of 18

1.6

1.23

0.0020

map01200

Carbon metabolism

5 of 76

1.2

1.03

0.0010

map00650

Butanoate metabolism

2 of 10

1.68

0.89

0.0166

map00190

Oxidative phosphorylation

4 of 70

1.14

0.86

0.0037

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0045272

Plasma membrane respiratory chain complex I

3 of 4

2.25

1.83

0.00033

GOCC:0098803

Respiratory chain complex

4 of 19

1.7

1.58

0.00033

GOCC:1990204

Oxidoreductase complex

4 of 33

1.46

1.28

0.00081

GOCC:1902494

Catalytic complex

5 of 150

0.9

0.64

0.0068

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0249

Electron transport

3 of 15

1.68

1.01

0.0087

KW-0816

Tricarboxylic acid cycle

2 of 7

1.83

0.82

0.0257

KW-0004

4Fe-4S

3 of 29

1.39

0.73

0.0257

KW-0560

Oxidoreductase

4 of 86

1.05

0.6

0.0257

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00037

4Fe-4S binding domain

5 of 6

2.3

3.53

8.60e-08

PF01515

Phosphate acetyl/butaryl transferase

2 of 2

2.38

0.92

0.0204

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR017900

4Fe-4S ferredoxin, iron-sulphur binding, conserved site

6 of 12

2.08

3.54

2.05e-08

IPR017896

4Fe-4S ferredoxin-type, iron-sulphur binding domain

6 of 16

1.95

3.25

4.08e-08

IPR042113

Phosphate acetyltransferase, domain 1

2 of 2

2.38

0.79

0.0356

IPR042112

Phosphate acetyltransferase, domain 2

2 of 2

2.38

0.79

0.0356

IPR002505

Phosphate acetyl/butaryl transferase

2 of 2

2.38

0.79

0.0356

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