SARC_12005 protein (Sphaeroforma arctica) - STRING interaction network

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second shell of interactors

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Edges:

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

SARC_12005

C2 domain-containing protein. (689 aa)

Predicted Functional Partners:

SARC_09059

0.649

SARC_10397

0.645

SARC_11539

0.640

SARC_13026

0.515

SARC_02511

0.515

SARC_18106

0.508

SARC_06668

0.508

SARC_01092

0.504

SARC_03383

0.499

SARC_02670

0.499

Your Current Organism:

Sphaeroforma arctica

NCBI taxonomy Id: 667725
Other names: S. arctica JP610, Sphaeroforma arctica JP610

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SARC_01092	SARC_06668	A0A0L0GER7	A0A0L0FVX0	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	Myotubularin phosphatase domain-containing protein.	0.601
SARC_01092	SARC_12005	A0A0L0GER7	A0A0L0FFB8	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	C2 domain-containing protein.	0.504
SARC_01092	SARC_18106	A0A0L0GER7	A0A0L0EY82	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	Myotubularin phosphatase domain-containing protein.	0.640
SARC_02511	SARC_06668	A0A0L0GAK9	A0A0L0FVX0	Myotubularin phosphatase domain-containing protein.	Myotubularin phosphatase domain-containing protein.	0.786
SARC_02511	SARC_09059	A0A0L0GAK9	A0A0L0FP48	Myotubularin phosphatase domain-containing protein.	SAC domain-containing protein.	0.810
SARC_02511	SARC_12005	A0A0L0GAK9	A0A0L0FFB8	Myotubularin phosphatase domain-containing protein.	C2 domain-containing protein.	0.515
SARC_02511	SARC_18106	A0A0L0GAK9	A0A0L0EY82	Myotubularin phosphatase domain-containing protein.	Myotubularin phosphatase domain-containing protein.	0.763
SARC_02670	SARC_03383	A0A0L0G8E6	A0A0L0G5T7	Maf-like protein.	Uncharacterized protein.	0.702
SARC_02670	SARC_12005	A0A0L0G8E6	A0A0L0FFB8	Maf-like protein.	C2 domain-containing protein.	0.499
SARC_03383	SARC_02670	A0A0L0G5T7	A0A0L0G8E6	Uncharacterized protein.	Maf-like protein.	0.702
SARC_03383	SARC_12005	A0A0L0G5T7	A0A0L0FFB8	Uncharacterized protein.	C2 domain-containing protein.	0.499
SARC_06668	SARC_01092	A0A0L0FVX0	A0A0L0GER7	Myotubularin phosphatase domain-containing protein.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.601
SARC_06668	SARC_02511	A0A0L0FVX0	A0A0L0GAK9	Myotubularin phosphatase domain-containing protein.	Myotubularin phosphatase domain-containing protein.	0.786
SARC_06668	SARC_09059	A0A0L0FVX0	A0A0L0FP48	Myotubularin phosphatase domain-containing protein.	SAC domain-containing protein.	0.715
SARC_06668	SARC_12005	A0A0L0FVX0	A0A0L0FFB8	Myotubularin phosphatase domain-containing protein.	C2 domain-containing protein.	0.508
SARC_06668	SARC_13026	A0A0L0FVX0	A0A0L0FCD2	Myotubularin phosphatase domain-containing protein.	Myotubularin phosphatase domain-containing protein.	0.733
SARC_09059	SARC_02511	A0A0L0FP48	A0A0L0GAK9	SAC domain-containing protein.	Myotubularin phosphatase domain-containing protein.	0.810
SARC_09059	SARC_06668	A0A0L0FP48	A0A0L0FVX0	SAC domain-containing protein.	Myotubularin phosphatase domain-containing protein.	0.715
SARC_09059	SARC_12005	A0A0L0FP48	A0A0L0FFB8	SAC domain-containing protein.	C2 domain-containing protein.	0.649
SARC_09059	SARC_13026	A0A0L0FP48	A0A0L0FCD2	SAC domain-containing protein.	Myotubularin phosphatase domain-containing protein.	0.780

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

43

average node degree:

7.82

avg. local clustering coefficient:

0.9

expected number of edges:

16

PPI enrichment p-value:

2.33e-08

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006289

Nucleotide-excision repair

4 of 34

2.37

2.64

8.50e-06

GO:0000724

Double-strand break repair via homologous recombination

4 of 109

1.86

1.66

0.00036

GO:0007004

Telomere maintenance via telomerase

2 of 7

2.75

1.47

0.0021

GO:0006281

DNA repair

5 of 369

1.43

1.34

0.00042

GO:0007049

Cell cycle

5 of 401

1.39

1.29

0.00047

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003684

Damaged DNA binding

3 of 32

2.27

1.62

0.00089

GO:0003697

Single-stranded DNA binding

3 of 39

2.19

1.6

0.00089

GO:0043047

Single-stranded telomeric DNA binding

2 of 6

2.82

1.38

0.0031

GO:0019888

Protein phosphatase regulator activity

2 of 25

2.2

0.96

0.0166

GO:0003677

DNA binding

6 of 1361

0.94

0.68

0.0060

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005662

DNA replication factor A complex

3 of 3

3.3

3.22

1.48e-06

GO:0000228

Nuclear chromosome

4 of 119

1.83

1.99

4.75e-05

GO:0000159

Protein phosphatase type 2A complex

2 of 5

2.9

1.88

0.00038

GO:0000781

Chromosome, telomeric region

2 of 39

2.01

1.12

0.0073

GO:0140513

Nuclear protein-containing complex

5 of 689

1.16

1.02

0.00075

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:14873

Mixed, incl. DNA damage checkpoint signaling, and HDR through Single Strand Annealing (SSA)

5 of 42

2.37

3.79

3.25e-08

CL:14945

RecQ family helicase-topoisomerase III complex, and DNA replication factor A complex

3 of 5

3.08

3.41

6.03e-07

CL:14812

DNA-templated DNA replication, and HDR through Single Strand Annealing (SSA)

6 of 194

1.79

2.88

7.75e-08

CL:3535

CTLA4 inhibitory signaling, and Serine esterase

2 of 6

2.82

1.74

0.00069

CL:14894

Mixed, incl. Replication factor A protein-like, and Single-stranded DNA helicase activity

2 of 6

2.82

1.74

0.00069

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03420

Nucleotide excision repair

7 of 299

1.67

2.94

4.48e-09

map03430

Mismatch repair

6 of 286

1.62

2.47

1.71e-07

map03030

DNA replication

6 of 328

1.56

2.31

2.55e-07

map03440

Homologous recombination

6 of 452

1.42

1.9

1.26e-06

map03015

mRNA surveillance pathway

2 of 107

1.57

0.7

0.0385

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5696395

Formation of Incision Complex in GG-NER

3 of 20

2.48

2.2

7.72e-05

MAP-5358606

Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)

2 of 7

2.75

1.66

0.00096

MAP-69273

Cyclin A/B1/B2 associated events during G2/M transition

2 of 10

2.6

1.64

0.00096

MAP-6783310

Fanconi Anemia Pathway

2 of 14

2.45

1.58

0.0012

MAP-5358565

Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)

2 of 13

2.49

1.58

0.0012

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005662

DNA replication factor A complex

2 of 4

3.0

1.38

0.0032

GOCC:0000159

Protein phosphatase type 2A complex

2 of 5

2.9

1.38

0.0032

GOCC:0005963

Magnesium-dependent protein serine/threonine phosphatase complex

2 of 7

2.75

1.37

0.0032

GOCC:0000228

Nuclear chromosome

3 of 181

1.52

0.95

0.0090

GOCC:0031981

Nuclear lumen

4 of 708

1.05

0.62

0.0221

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01336

OB-fold nucleic acid binding domain

2 of 7

2.75

1.17

0.0074

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR040260

Replication factor A protein-like

2 of 2

3.3

1.36

0.0036

IPR012340

Nucleic acid-binding, OB-fold

3 of 57

2.02

1.24

0.0041

IPR004365

OB-fold nucleic acid binding domain, AA-tRNA synthetase-type

2 of 7

2.75

1.18

0.0072

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