SARC_03298 protein (Sphaeroforma arctica) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

SARC_03298

Rad51 domain-containing protein. (280 aa)

Predicted Functional Partners:

SARC_08618

0.996

SARC_04012

0.996

SARC_00198

0.991

SARC_03700

0.984

SARC_15642

0.966

SARC_01049

0.966

SARC_05714

0.919

SARC_03815

0.899

SARC_10687

0.886

SARC_06166

0.886

Your Current Organism:

Sphaeroforma arctica

NCBI taxonomy Id: 667725
Other names: S. arctica JP610, Sphaeroforma arctica JP610

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SARC_00198	SARC_01049	A0A0L0GFS8	A0A0L0GCS4	RECA_2 domain-containing protein.	Rad51 domain-containing protein.	0.913
SARC_00198	SARC_03298	A0A0L0GFS8	A0A0L0G638	RECA_2 domain-containing protein.	Rad51 domain-containing protein.	0.991
SARC_00198	SARC_03700	A0A0L0GFS8	A0A0L0G4W5	RECA_2 domain-containing protein.	RECA_2 domain-containing protein.	0.981
SARC_00198	SARC_03815	A0A0L0GFS8	A0A0L0G551	RECA_2 domain-containing protein.	RECA_2 domain-containing protein.	0.971
SARC_00198	SARC_04012	A0A0L0GFS8	A0A0L0G3S6	RECA_2 domain-containing protein.	Helicase C-terminal domain-containing protein.	0.979
SARC_00198	SARC_05714	A0A0L0GFS8	A0A0L0FYS7	RECA_2 domain-containing protein.	DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. Belongs to the RecA family. RAD51 subfamily.	0.858
SARC_00198	SARC_06166	A0A0L0GFS8	A0A0L0FXF0	RECA_2 domain-containing protein.	Meiotic recombination protein DMC1/LIM15.	0.885
SARC_00198	SARC_08618	A0A0L0GFS8	A0A0L0FQB2	RECA_2 domain-containing protein.	3'-5' exonuclease domain-containing protein.	0.979
SARC_00198	SARC_10687	A0A0L0GFS8	A0A0L0FLD3	RECA_2 domain-containing protein.	PfkB domain-containing protein.	0.885
SARC_00198	SARC_15642	A0A0L0GFS8	A0A0L0F5G1	RECA_2 domain-containing protein.	RECA_2 domain-containing protein.	0.913
SARC_01049	SARC_00198	A0A0L0GCS4	A0A0L0GFS8	Rad51 domain-containing protein.	RECA_2 domain-containing protein.	0.913
SARC_01049	SARC_03298	A0A0L0GCS4	A0A0L0G638	Rad51 domain-containing protein.	Rad51 domain-containing protein.	0.966
SARC_01049	SARC_03700	A0A0L0GCS4	A0A0L0G4W5	Rad51 domain-containing protein.	RECA_2 domain-containing protein.	0.966
SARC_01049	SARC_03815	A0A0L0GCS4	A0A0L0G551	Rad51 domain-containing protein.	RECA_2 domain-containing protein.	0.965
SARC_01049	SARC_04012	A0A0L0GCS4	A0A0L0G3S6	Rad51 domain-containing protein.	Helicase C-terminal domain-containing protein.	0.979
SARC_01049	SARC_05714	A0A0L0GCS4	A0A0L0FYS7	Rad51 domain-containing protein.	DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. Belongs to the RecA family. RAD51 subfamily.	0.814
SARC_01049	SARC_06166	A0A0L0GCS4	A0A0L0FXF0	Rad51 domain-containing protein.	Meiotic recombination protein DMC1/LIM15.	0.900
SARC_01049	SARC_08618	A0A0L0GCS4	A0A0L0FQB2	Rad51 domain-containing protein.	3'-5' exonuclease domain-containing protein.	0.979
SARC_01049	SARC_10687	A0A0L0GCS4	A0A0L0FLD3	Rad51 domain-containing protein.	PfkB domain-containing protein.	0.900
SARC_01049	SARC_15642	A0A0L0GCS4	A0A0L0F5G1	Rad51 domain-containing protein.	RECA_2 domain-containing protein.	0.536

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

33

average node degree:

6

avg. local clustering coefficient:

0.749

expected number of edges:

15

PPI enrichment p-value:

6.17e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0034728

Nucleosome organization

4 of 69

2.32

2.9

7.50e-06

GO:0006334

Nucleosome assembly

3 of 33

2.51

2.42

8.06e-05

GO:0031497

Chromatin assembly

4 of 130

2.04

2.38

3.52e-05

GO:0006325

Chromatin organization

5 of 306

1.77

2.26

1.48e-05

GO:0051276

Chromosome organization

6 of 534

1.6

2.14

6.62e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003682

Chromatin binding

6 of 252

1.93

3.48

2.66e-08

GO:0031492

Nucleosomal DNA binding

3 of 12

2.95

3.16

6.17e-06

GO:0030527

Structural constituent of chromatin

3 of 12

2.95

3.16

6.17e-06

GO:0046982

Protein heterodimerization activity

3 of 115

1.97

1.65

0.0010

GO:0005515

Protein binding

8 of 2974

0.98

1.04

6.58e-06

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000785

Chromatin

6 of 204

2.02

3.97

4.07e-09

GO:0000786

Nucleosome

3 of 20

2.73

3.16

5.15e-06

GO:0005694

Chromosome

7 of 542

1.66

3.04

4.07e-09

GO:0005700

Polytene chromosome

3 of 165

1.81

1.56

0.0011

GO:0140513

Nuclear protein-containing complex

5 of 743

1.38

1.53

7.98e-05

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:36760483

(2022) Sympatry of genetic lineages of Parisotomanotabilis s. l. (Collembola, Isotomidae) in the East European Plain.

2 of 2

3.55

2.59

6.42e-05

PMID:31919378

(2020) Rapid and cost-effective generation of single specimen multilocus barcoding data from whole arthropod communities by multiple levels of multiplexing.

2 of 2

3.55

2.59

6.42e-05

PMID:28397786

(2017) Cretaceous origin of the unique prey-capture apparatus in mega-diverse genus: stem lineage of Steninae rove beetles discovered in Burmese amber.

2 of 2

3.55

2.59

6.42e-05

PMID:28170395

(2017) Genetic structure and distribution of Parisotoma notabilis (Collembola) in Europe: Cryptic diversity, split of lineages and colonization patterns.

2 of 2

3.55

2.59

6.42e-05

PMID:34542224

(2022) Delete and survive: strategies of programmed genetic material elimination in eukaryotes.

2 of 6

3.08

2.56

6.42e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2638

Mixed, incl. Histone deacetylase complex, and Structural constituent of chromatin

4 of 79

2.26

2.71

1.46e-05

CL:2650

Structural constituent of chromatin, and Set1C/COMPASS complex

3 of 21

2.71

2.7

3.08e-05

CL:2652

Structural constituent of chromatin, and Set1C/COMPASS complex

2 of 16

2.65

1.5

0.0033

CL:3032

Mixed, incl. Chromo/chromo shadow domain, and Transcriptional Regulation by E2F6

2 of 56

2.11

0.88

0.0325

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8878171

Transcriptional regulation by RUNX1

4 of 207

1.84

2.02

0.00010

MAP-983231

Factors involved in megakaryocyte development and platelet production

3 of 99

2.03

1.76

0.00067

MAP-8936459

RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

3 of 133

1.91

1.57

0.0013

MAP-212436

Generic Transcription Pathway

6 of 1073

1.3

1.39

0.00010

MAP-73857

RNA Polymerase II Transcription

6 of 1198

1.25

1.32

0.00010

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000786

Nucleosome

3 of 12

2.95

3.25

4.25e-06

GOCC:0000785

Chromatin

5 of 186

1.98

3.01

9.07e-07

GOCC:0032991

Protein-containing complex

6 of 3032

0.85

0.62

0.0054

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0158

Chromosome

3 of 31

2.54

2.99

7.81e-06

KW-0539

Nucleus

6 of 495

1.64

2.59

2.09e-07

KW-0238

DNA-binding

5 of 371

1.68

2.37

2.84e-06

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000164

Histone H3/CENP-A

3 of 5

3.33

3.38

3.11e-06

IPR007125

Histone H2A/H2B/H3

3 of 8

3.13

3.26

4.58e-06

IPR009072

Histone-fold

3 of 25

2.63

2.52

6.05e-05

IPR023780

Chromo domain

2 of 23

2.49

1.03

0.0198

IPR016197

Chromo-like domain superfamily

2 of 30

2.38

0.99

0.0229

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00428

Histone H3

3 of 5

3.33

3.9

4.21e-07

SM00298

Chromatin organization modifier domain

2 of 30

2.38

1.23

0.0088

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (22%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About