STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KZX13810.1Mevalonate kinase. (285 aa)    
Predicted Functional Partners:
KZX09954.1
Hypothetical protein.
 
  
 0.992
panE
2-dehydropantoate 2-reductase.
    
 0.915
KZX13220.1
2-dehydropantoate 2-reductase.
    
 0.915
htpX
Hypothetical protein; Protease HtpX homolog; Belongs to the peptidase M48B family.
  
    0.816
tam
Trans-aconitate 2-methyltransferase.
       0.773
KZX13811.1
Hypothetical protein.
       0.773
alaS
alanine--tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
  
    0.747
metE
5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase.
  
    0.733
tfe
Transcription initiation factor E subunit alpha; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elo [...]
  
    0.632
nusA
Hypothetical protein; Participates in transcription termination. Belongs to the NusA family.
  
     0.611
Your Current Organism:
Methanobrevibacter oralis
NCBI taxonomy Id: 66851
Other names: DSM 7256, M. oralis, strain ZR
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.