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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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[Homology]
Score
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (549 aa)    
Predicted Functional Partners:
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.999
ilvE
Branched-chain-amino-acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
  
 0.998
leuA_2
2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
 
 0.988
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
  
  
 0.942
ilvH
Putative acetolactate synthase small subunit.
  
 
 0.941
ilvB_2
Acetolactate synthase large subunit.
 
 0.937
dmdA_1
2,3-dimethylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
  
  
 0.854
dmdA_2
2,3-dimethylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
  
  
 0.854
ilvG
Acetolactate synthase isozyme 2 large subunit; Belongs to the TPP enzyme family.
 
 0.852
gdhA
NAD(P)-specific glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
   
 
 0.824
Your Current Organism:
Methanobrevibacter oralis
NCBI taxonomy Id: 66851
Other names: DSM 7256, M. oralis, strain ZR
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