Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
KZX13574.1Histone-like transcription factor (CBF/NF-Y) and archaeal histone. (66 aa)    
Predicted Functional Partners:
KZX13016.1
DHHA1 domain protein.
  
     0.630
tfe
Transcription initiation factor E subunit alpha; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elo [...]
  
   
 0.627
KZX11831.1
DHH family protein.
  
     0.596
thrS
threonine--tRNA ligase; Belongs to the class-II aminoacyl-tRNA synthetase family.
  
    0.590
KZX11843.1
Type II/IV secretion system protein.
  
     0.580
polB
DNA polymerase II small subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family.
  
  
  0.528
dbpA_3
ATP-dependent RNA helicase DbpA.
  
     0.520
tsaD
tRNA N6-adenosine threonylcarbamoyltransferase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family.
    
 
 0.494
KZX12198.1
RNA polymerase Rpb4.
  
   
 0.485
nusA
Hypothetical protein; Participates in transcription termination. Belongs to the NusA family.
  
     0.472
Your Current Organism:
Methanobrevibacter oralis
NCBI taxonomy Id: 66851
Other names: DSM 7256, M. oralis, strain ZR
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