C7M84_006754 protein (Penaeus vannamei) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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C7M84_006754

RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (908 aa)

Predicted Functional Partners:

C7M84_010007

0.931

C7M84_004453

0.931

C7M84_002987

0.929

C7M84_019584

0.928

C7M84_020472

0.925

C7M84_007714

0.924

C7M84_008489

0.922

C7M84_002584

0.915

C7M84_012508

0.913

C7M84_012965

0.912

Your Current Organism:

Penaeus vannamei

NCBI taxonomy Id: 6689
Other names: Litopenaeus vannamei, P. vannamei, Pacific white shrimp, Penaeus (Litopenaeus) vannamei, Penaeus sp. AT-2008, white Pacific shrimp, white shrimp

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C7M84_002584	C7M84_002987	A0A3R7PVX0	A0A3R7PVJ6	Putative nucleolar protein 58-like.	Nucleolar protein-like protein 5A.	0.999
C7M84_002584	C7M84_004453	A0A3R7PVX0	A0A3R7P6N3	Putative nucleolar protein 58-like.	Periodic tryptophan protein 2-like protein.	0.995
C7M84_002584	C7M84_006754	A0A3R7PVX0	A0A423TE35	Putative nucleolar protein 58-like.	RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.	0.915
C7M84_002584	C7M84_007714	A0A3R7PVX0	A0A423TBK4	Putative nucleolar protein 58-like.	Nucleolar protein 6.	0.993
C7M84_002584	C7M84_008489	A0A3R7PVX0	A0A423T9M2	Putative nucleolar protein 58-like.	WD_REPEATS_REGION domain-containing protein.	0.992
C7M84_002584	C7M84_010007	A0A3R7PVX0	A0A3R7P072	Putative nucleolar protein 58-like.	HEAT repeat-containing protein 1.	0.999
C7M84_002584	C7M84_012508	A0A3R7PVX0	A0A3R7PK99	Putative nucleolar protein 58-like.	Uncharacterized protein.	0.992
C7M84_002584	C7M84_012965	A0A3R7PVX0	A0A423SXQ2	Putative nucleolar protein 58-like.	Putative bystin isoform X1.	0.996
C7M84_002584	C7M84_019584	A0A3R7PVX0	A0A3R7QBI4	Putative nucleolar protein 58-like.	Putative WD repeat-containing protein 36.	0.996
C7M84_002584	C7M84_020472	A0A3R7PVX0	A0A3R7PCV6	Putative nucleolar protein 58-like.	Putative transducin beta-like protein 3.	0.998
C7M84_002987	C7M84_002584	A0A3R7PVJ6	A0A3R7PVX0	Nucleolar protein-like protein 5A.	Putative nucleolar protein 58-like.	0.999
C7M84_002987	C7M84_004453	A0A3R7PVJ6	A0A3R7P6N3	Nucleolar protein-like protein 5A.	Periodic tryptophan protein 2-like protein.	0.991
C7M84_002987	C7M84_006754	A0A3R7PVJ6	A0A423TE35	Nucleolar protein-like protein 5A.	RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.	0.929
C7M84_002987	C7M84_007714	A0A3R7PVJ6	A0A423TBK4	Nucleolar protein-like protein 5A.	Nucleolar protein 6.	0.992
C7M84_002987	C7M84_008489	A0A3R7PVJ6	A0A423T9M2	Nucleolar protein-like protein 5A.	WD_REPEATS_REGION domain-containing protein.	0.955
C7M84_002987	C7M84_010007	A0A3R7PVJ6	A0A3R7P072	Nucleolar protein-like protein 5A.	HEAT repeat-containing protein 1.	0.996
C7M84_002987	C7M84_012508	A0A3R7PVJ6	A0A3R7PK99	Nucleolar protein-like protein 5A.	Uncharacterized protein.	0.983
C7M84_002987	C7M84_012965	A0A3R7PVJ6	A0A423SXQ2	Nucleolar protein-like protein 5A.	Putative bystin isoform X1.	0.993
C7M84_002987	C7M84_019584	A0A3R7PVJ6	A0A3R7QBI4	Nucleolar protein-like protein 5A.	Putative WD repeat-containing protein 36.	0.995
C7M84_002987	C7M84_020472	A0A3R7PVJ6	A0A3R7PCV6	Nucleolar protein-like protein 5A.	Putative transducin beta-like protein 3.	0.994

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Network Stats

number of nodes:

11

number of edges:

40

average node degree:

7.27

avg. local clustering coefficient:

0.903

expected number of edges:

10

PPI enrichment p-value:

1.06e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006744

Ubiquinone biosynthetic process

10 of 17

2.31

7.86

6.69e-19

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008425

2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity

3 of 4

2.42

1.78

0.00047

GO:0016705

Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

4 of 27

1.71

1.53

0.00047

GO:0071949

FAD binding

3 of 15

1.84

1.32

0.0022

GO:0102208

2-polyprenyl-6-hydroxyphenol methylase activity

2 of 3

2.37

1.09

0.0097

GO:0008689

3-demethylubiquinone-9 3-O-methyltransferase activity

2 of 3

2.37

1.09

0.0097

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0110142

Ubiquinone biosynthesis complex

4 of 5

2.45

3.23

6.24e-07

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3314

Ubiquinone metabolic process

9 of 14

2.35

7.29

7.38e-17

CL:3316

Ubiquinone biosynthesis complex, and Ubiquinone biosynthesis O-methyltransferase

7 of 7

2.54

6.55

6.37e-14

CL:3309

Mixed, incl. Ubiquinone metabolic process, and Translocase

10 of 50

1.84

4.9

1.17e-15

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

amg00130

Ubiquinone and other terpenoid-quinone biosynthesis

8 of 14

2.3

6.47

4.82e-15

amg01110

Biosynthesis of secondary metabolites

8 of 289

0.99

1.04

8.45e-06

amg01100

Metabolic pathways

8 of 650

0.63

0.49

0.0026

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0110142

Ubiquinone biosynthesis complex

6 of 14

2.18

4.16

1.27e-09

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0830

Ubiquinone

8 of 15

2.27

6.2

1.56e-14

KW-0831

Ubiquinone biosynthesis

5 of 7

2.4

4.14

5.99e-09

KW-0949

S-adenosyl-L-methionine

3 of 59

1.25

0.6

0.0465

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13489

Methyltransferase domain

3 of 8

2.12

1.45

0.0017

PF08491

Squalene epoxidase

2 of 2

2.54

1.03

0.0134

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR010971

Ubiquinone biosynthesis hydroxylase UbiH/COQ6

3 of 3

2.54

1.77

0.00053

IPR002938

FAD-binding domain

3 of 4

2.42

1.76

0.00053

IPR018168

Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6, conserved site

2 of 2

2.54

0.9

0.0227

IPR010233

Ubiquinone biosynthesis O-methyltransferase

2 of 2

2.54

0.9

0.0227

IPR036188

FAD/NAD(P)-binding domain superfamily

3 of 34

1.49

0.68

0.0392

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