| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AMF97691.1 | hfq | AL538_08090 | AL538_08095 | GTPase HflX; Involved in modulation of proteins HflK and HflC; part of the hflA locus (high frequency of lysogenization) which governs the lysis-lysogeny decision of bacteriophage lambda by controlling stability of the phage cII protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | RNA chaperone Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | 0.927 |
| AMF97691.1 | miaA | AL538_08090 | AL538_08100 | GTPase HflX; Involved in modulation of proteins HflK and HflC; part of the hflA locus (high frequency of lysogenization) which governs the lysis-lysogeny decision of bacteriophage lambda by controlling stability of the phage cII protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. | 0.957 |
| clpX | hfq | AL538_14255 | AL538_08095 | ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | RNA chaperone Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | 0.892 |
| csrA | dksA | AL538_06670 | AL538_06405 | Carbon storage regulator; Affects carbohydrate metabolism; has regulatory role in many processes; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CsrA/RsmA family. | RNA polymerase-binding transcription factor; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.725 |
| csrA | hfq | AL538_06670 | AL538_08095 | Carbon storage regulator; Affects carbohydrate metabolism; has regulatory role in many processes; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CsrA/RsmA family. | RNA chaperone Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | 0.964 |
| csrA | luxO | AL538_06670 | AL538_04125 | Carbon storage regulator; Affects carbohydrate metabolism; has regulatory role in many processes; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CsrA/RsmA family. | AAA family ATPase; Acts negatively to control the expression of luminescence. At low cell density, LuxO is phosphorylated, and together with sigma-54, causes repression of the luxCDABEGH operon. This repression could be indirect, LuxO could activate a negative regulator of luminescence. At high cell density, LuxO is dephosphorylated and inactive, therefore the luxCDABEGH operon is not repressed and light is emitted. LuxO and sigma-54 have also a role in activating the production of siderophore and in regulating the rugose colony morphology phenotype (By similarity). | 0.467 |
| csrA | ptsH | AL538_06670 | AL538_13515 | Carbon storage regulator; Affects carbohydrate metabolism; has regulatory role in many processes; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CsrA/RsmA family. | PTS sugar transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.543 |
| dksA | csrA | AL538_06405 | AL538_06670 | RNA polymerase-binding transcription factor; Derived by automated computational analysis using gene prediction method: Protein Homology. | Carbon storage regulator; Affects carbohydrate metabolism; has regulatory role in many processes; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CsrA/RsmA family. | 0.725 |
| dksA | hfq | AL538_06405 | AL538_08095 | RNA polymerase-binding transcription factor; Derived by automated computational analysis using gene prediction method: Protein Homology. | RNA chaperone Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | 0.925 |
| dksA | ptsH | AL538_06405 | AL538_13515 | RNA polymerase-binding transcription factor; Derived by automated computational analysis using gene prediction method: Protein Homology. | PTS sugar transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.549 |
| hfq | AMF97691.1 | AL538_08095 | AL538_08090 | RNA chaperone Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | GTPase HflX; Involved in modulation of proteins HflK and HflC; part of the hflA locus (high frequency of lysogenization) which governs the lysis-lysogeny decision of bacteriophage lambda by controlling stability of the phage cII protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.927 |
| hfq | clpX | AL538_08095 | AL538_14255 | RNA chaperone Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.892 |
| hfq | csrA | AL538_08095 | AL538_06670 | RNA chaperone Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | Carbon storage regulator; Affects carbohydrate metabolism; has regulatory role in many processes; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CsrA/RsmA family. | 0.964 |
| hfq | dksA | AL538_08095 | AL538_06405 | RNA chaperone Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | RNA polymerase-binding transcription factor; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.925 |
| hfq | luxO | AL538_08095 | AL538_04125 | RNA chaperone Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | AAA family ATPase; Acts negatively to control the expression of luminescence. At low cell density, LuxO is phosphorylated, and together with sigma-54, causes repression of the luxCDABEGH operon. This repression could be indirect, LuxO could activate a negative regulator of luminescence. At high cell density, LuxO is dephosphorylated and inactive, therefore the luxCDABEGH operon is not repressed and light is emitted. LuxO and sigma-54 have also a role in activating the production of siderophore and in regulating the rugose colony morphology phenotype (By similarity). | 0.914 |
| hfq | luxR | AL538_08095 | AL538_06465 | RNA chaperone Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | LuxR family transcriptional regulator; Regulatory protein of bacterial bioluminescence. It probably binds the autoinducer molecule and potentiates the transcription of the bioluminescence operon. | 0.900 |
| hfq | luxU | AL538_08095 | AL538_04120 | RNA chaperone Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | Phosphorelay protein LuxU; Phosphorelay protein which receives sensory signals from LuxN and LuxP and transmits them to LuxO, at low cell density. LuxN and LuxP transfer a phosphoryl group to LuxU on His-58 and this phosphoryl group is further transferred to LuxO. At high cell density, as LuxU could function to establish an equilibrium between the aspartyl-phosphate of LuxN and the aspartyl-phosphate of LuxO, LuxU transfers phosphate from LuxO to LuxN (and probably LuxP) and finally phosphate is drained from the system. | 0.912 |
| hfq | miaA | AL538_08095 | AL538_08100 | RNA chaperone Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. | 0.923 |
| hfq | ptsH | AL538_08095 | AL538_13515 | RNA chaperone Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | PTS sugar transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.903 |
| hfq | xth | AL538_08095 | AL538_14695 | RNA chaperone Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | Exodeoxyribonuclease III; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.907 |