| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| clpX | hfq | AL538_14255 | AL538_08095 | ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | RNA chaperone Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | 0.850 |
| clpX | ihfA | AL538_14255 | AL538_02015 | ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | Integration host factor subunit alpha; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. | 0.685 |
| csrA | dksA | AL538_06670 | AL538_06405 | Carbon storage regulator; Affects carbohydrate metabolism; has regulatory role in many processes; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CsrA/RsmA family. | RNA polymerase-binding transcription factor; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.579 |
| csrA | hfq | AL538_06670 | AL538_08095 | Carbon storage regulator; Affects carbohydrate metabolism; has regulatory role in many processes; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CsrA/RsmA family. | RNA chaperone Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | 0.937 |
| csrA | ihfA | AL538_06670 | AL538_02015 | Carbon storage regulator; Affects carbohydrate metabolism; has regulatory role in many processes; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CsrA/RsmA family. | Integration host factor subunit alpha; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. | 0.762 |
| csrA | luxO | AL538_06670 | AL538_04125 | Carbon storage regulator; Affects carbohydrate metabolism; has regulatory role in many processes; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CsrA/RsmA family. | AAA family ATPase; Acts negatively to control the expression of luminescence. At low cell density, LuxO is phosphorylated, and together with sigma-54, causes repression of the luxCDABEGH operon. This repression could be indirect, LuxO could activate a negative regulator of luminescence. At high cell density, LuxO is dephosphorylated and inactive, therefore the luxCDABEGH operon is not repressed and light is emitted. LuxO and sigma-54 have also a role in activating the production of siderophore and in regulating the rugose colony morphology phenotype (By similarity). | 0.501 |
| csrA | luxR | AL538_06670 | AL538_06465 | Carbon storage regulator; Affects carbohydrate metabolism; has regulatory role in many processes; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CsrA/RsmA family. | LuxR family transcriptional regulator; Regulatory protein of bacterial bioluminescence. It probably binds the autoinducer molecule and potentiates the transcription of the bioluminescence operon. | 0.487 |
| csrA | pnp | AL538_06670 | AL538_06155 | Carbon storage regulator; Affects carbohydrate metabolism; has regulatory role in many processes; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CsrA/RsmA family. | Polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. | 0.562 |
| csrA | ptsH | AL538_06670 | AL538_13515 | Carbon storage regulator; Affects carbohydrate metabolism; has regulatory role in many processes; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CsrA/RsmA family. | PTS sugar transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.501 |
| dksA | csrA | AL538_06405 | AL538_06670 | RNA polymerase-binding transcription factor; Derived by automated computational analysis using gene prediction method: Protein Homology. | Carbon storage regulator; Affects carbohydrate metabolism; has regulatory role in many processes; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CsrA/RsmA family. | 0.579 |
| dksA | hfq | AL538_06405 | AL538_08095 | RNA polymerase-binding transcription factor; Derived by automated computational analysis using gene prediction method: Protein Homology. | RNA chaperone Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | 0.851 |
| dksA | ihfA | AL538_06405 | AL538_02015 | RNA polymerase-binding transcription factor; Derived by automated computational analysis using gene prediction method: Protein Homology. | Integration host factor subunit alpha; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. | 0.548 |
| dksA | ptsH | AL538_06405 | AL538_13515 | RNA polymerase-binding transcription factor; Derived by automated computational analysis using gene prediction method: Protein Homology. | PTS sugar transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.509 |
| hfq | clpX | AL538_08095 | AL538_14255 | RNA chaperone Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.850 |
| hfq | csrA | AL538_08095 | AL538_06670 | RNA chaperone Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | Carbon storage regulator; Affects carbohydrate metabolism; has regulatory role in many processes; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CsrA/RsmA family. | 0.937 |
| hfq | dksA | AL538_08095 | AL538_06405 | RNA chaperone Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | RNA polymerase-binding transcription factor; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.851 |
| hfq | ihfA | AL538_08095 | AL538_02015 | RNA chaperone Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | Integration host factor subunit alpha; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. | 0.863 |
| hfq | luxO | AL538_08095 | AL538_04125 | RNA chaperone Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | AAA family ATPase; Acts negatively to control the expression of luminescence. At low cell density, LuxO is phosphorylated, and together with sigma-54, causes repression of the luxCDABEGH operon. This repression could be indirect, LuxO could activate a negative regulator of luminescence. At high cell density, LuxO is dephosphorylated and inactive, therefore the luxCDABEGH operon is not repressed and light is emitted. LuxO and sigma-54 have also a role in activating the production of siderophore and in regulating the rugose colony morphology phenotype (By similarity). | 0.844 |
| hfq | luxR | AL538_08095 | AL538_06465 | RNA chaperone Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | LuxR family transcriptional regulator; Regulatory protein of bacterial bioluminescence. It probably binds the autoinducer molecule and potentiates the transcription of the bioluminescence operon. | 0.834 |
| hfq | miaA | AL538_08095 | AL538_08100 | RNA chaperone Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. | 0.835 |