node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALU74138.1 | ALU74173.1 | AUW17_02105 | AUW17_02315 | 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Tetrahydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.672 |
ALU74138.1 | ALU74216.1 | AUW17_02105 | AUW17_02570 | 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.992 |
ALU74138.1 | ALU75820.1 | AUW17_02105 | AUW17_11425 | 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.512 |
ALU74138.1 | folE | AUW17_02105 | AUW17_04270 | 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | GTP cyclohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.932 |
ALU74138.1 | glyA | AUW17_02105 | AUW17_06115 | 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.439 |
ALU74170.1 | ALU74172.1 | AUW17_02300 | AUW17_02310 | Biopolymer transporter ExbB; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.863 |
ALU74170.1 | ALU74173.1 | AUW17_02300 | AUW17_02315 | Biopolymer transporter ExbB; Derived by automated computational analysis using gene prediction method: Protein Homology. | Tetrahydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.641 |
ALU74172.1 | ALU74170.1 | AUW17_02310 | AUW17_02300 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Biopolymer transporter ExbB; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.863 |
ALU74172.1 | ALU74173.1 | AUW17_02310 | AUW17_02315 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Tetrahydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.697 |
ALU74173.1 | ALU74138.1 | AUW17_02315 | AUW17_02105 | Tetrahydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.672 |
ALU74173.1 | ALU74170.1 | AUW17_02315 | AUW17_02300 | Tetrahydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Biopolymer transporter ExbB; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.641 |
ALU74173.1 | ALU74172.1 | AUW17_02315 | AUW17_02310 | Tetrahydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.697 |
ALU74173.1 | ALU74216.1 | AUW17_02315 | AUW17_02570 | Tetrahydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.997 |
ALU74173.1 | ALU74280.1 | AUW17_02315 | AUW17_02905 | Tetrahydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Thymidylate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.826 |
ALU74173.1 | ALU75820.1 | AUW17_02315 | AUW17_11425 | Tetrahydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.927 |
ALU74173.1 | fhs | AUW17_02315 | AUW17_10605 | Tetrahydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Formate--tetrahydrofolate ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the formate--tetrahydrofolate ligase family. | 0.684 |
ALU74173.1 | folE | AUW17_02315 | AUW17_04270 | Tetrahydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | GTP cyclohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.654 |
ALU74173.1 | glyA | AUW17_02315 | AUW17_06115 | Tetrahydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.692 |
ALU74173.1 | thyA | AUW17_02315 | AUW17_11430 | Tetrahydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.826 |
ALU74216.1 | ALU74138.1 | AUW17_02570 | AUW17_02105 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.992 |