| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AGS06855.1 | AGS06856.1 | SSDC_00820 | SSDC_00825 | Histidine triad (HIT) protein; COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases. | Hypothetical protein. | 0.787 |
| AGS06855.1 | bioC | SSDC_00820 | SSDC_00815 | Histidine triad (HIT) protein; COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases. | Biotin synthesis protein bioC; COG0500 SAM-dependent methyltransferases. | 0.859 |
| AGS06855.1 | dipP | SSDC_00820 | SSDC_00650 | Histidine triad (HIT) protein; COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases. | COG3321 Polyketide synthase modules and related proteins; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.690 |
| AGS06855.1 | ribD | SSDC_00820 | SSDC_01345 | Histidine triad (HIT) protein; COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.457 |
| AGS06856.1 | AGS06855.1 | SSDC_00825 | SSDC_00820 | Hypothetical protein. | Histidine triad (HIT) protein; COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases. | 0.787 |
| AGS06856.1 | bioC | SSDC_00825 | SSDC_00815 | Hypothetical protein. | Biotin synthesis protein bioC; COG0500 SAM-dependent methyltransferases. | 0.779 |
| AGS06856.1 | dipP | SSDC_00825 | SSDC_00650 | Hypothetical protein. | COG3321 Polyketide synthase modules and related proteins; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.536 |
| AGS06941.1 | bioC | SSDC_01260 | SSDC_00815 | Hypothetical protein. | Biotin synthesis protein bioC; COG0500 SAM-dependent methyltransferases. | 0.696 |
| bioA | bioB | SSDC_01350 | SSDC_01355 | COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Biotin synthase (biotin synthetase); Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.991 |
| bioA | bioC | SSDC_01350 | SSDC_00815 | COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Biotin synthesis protein bioC; COG0500 SAM-dependent methyltransferases. | 0.691 |
| bioA | bioD | SSDC_01350 | SSDC_00485 | COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Dithiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.999 |
| bioA | dipO | SSDC_01350 | SSDC_00655 | COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Mixed type I polyketide synthase/non-ribosomal peptide synthetase, PedH-like protein; COG3321 Polyketide synthase modules and related proteins. | 0.530 |
| bioA | dipP | SSDC_01350 | SSDC_00650 | COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | COG3321 Polyketide synthase modules and related proteins; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.948 |
| bioA | ribAB | SSDC_01350 | SSDC_00885 | COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Bifunctional riboflavin biosynthesis protein; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.858 |
| bioA | ribD | SSDC_01350 | SSDC_01345 | COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.952 |
| bioB | bioA | SSDC_01355 | SSDC_01350 | Biotin synthase (biotin synthetase); Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.991 |
| bioB | bioC | SSDC_01355 | SSDC_00815 | Biotin synthase (biotin synthetase); Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Biotin synthesis protein bioC; COG0500 SAM-dependent methyltransferases. | 0.786 |
| bioB | bioD | SSDC_01355 | SSDC_00485 | Biotin synthase (biotin synthetase); Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Dithiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.998 |
| bioB | dipP | SSDC_01355 | SSDC_00650 | Biotin synthase (biotin synthetase); Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | COG3321 Polyketide synthase modules and related proteins; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.538 |
| bioB | ribAB | SSDC_01355 | SSDC_00885 | Biotin synthase (biotin synthetase); Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Bifunctional riboflavin biosynthesis protein; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.858 |