| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AGS06699.1 | dnaJ | SSDC_00010 | SSDC_01120 | NAD-dependent epimerase/dehydratase; COG0451 Nucleoside-diphosphate-sugar epimerases. | Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | 0.726 |
| AGS06699.1 | metK | SSDC_00010 | SSDC_01855 | NAD-dependent epimerase/dehydratase; COG0451 Nucleoside-diphosphate-sugar epimerases. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.963 |
| AGS06699.1 | pheT | SSDC_00010 | SSDC_00385 | NAD-dependent epimerase/dehydratase; COG0451 Nucleoside-diphosphate-sugar epimerases. | phenylalanyl-tRNA synthetase subunit beta; COG0073 EMAP domain; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.411 |
| AGS06699.1 | ribAB | SSDC_00010 | SSDC_00885 | NAD-dependent epimerase/dehydratase; COG0451 Nucleoside-diphosphate-sugar epimerases. | Bifunctional riboflavin biosynthesis protein; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.925 |
| AGS06699.1 | ribD | SSDC_00010 | SSDC_01345 | NAD-dependent epimerase/dehydratase; COG0451 Nucleoside-diphosphate-sugar epimerases. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.767 |
| AGS06699.1 | ribH | SSDC_00010 | SSDC_00890 | NAD-dependent epimerase/dehydratase; COG0451 Nucleoside-diphosphate-sugar epimerases. | Riboflavin synthase subunit beta; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.406 |
| AGS07057.1 | ahcY | SSDC_01865 | SSDC_01850 | Bifunctional biotin-[acetylCoA carboxylase] holoenzyme synthetase/transcriptional repressor; COG0340 Biotin-(acetyl-CoA carboxylase) ligase. | S-adenosylhomocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.528 |
| AGS07057.1 | metK | SSDC_01865 | SSDC_01855 | Bifunctional biotin-[acetylCoA carboxylase] holoenzyme synthetase/transcriptional repressor; COG0340 Biotin-(acetyl-CoA carboxylase) ligase. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.786 |
| AGS07057.1 | pheT | SSDC_01865 | SSDC_00385 | Bifunctional biotin-[acetylCoA carboxylase] holoenzyme synthetase/transcriptional repressor; COG0340 Biotin-(acetyl-CoA carboxylase) ligase. | phenylalanyl-tRNA synthetase subunit beta; COG0073 EMAP domain; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.630 |
| AGS07057.1 | ribAB | SSDC_01865 | SSDC_00885 | Bifunctional biotin-[acetylCoA carboxylase] holoenzyme synthetase/transcriptional repressor; COG0340 Biotin-(acetyl-CoA carboxylase) ligase. | Bifunctional riboflavin biosynthesis protein; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.894 |
| AGS07057.1 | ribD | SSDC_01865 | SSDC_01345 | Bifunctional biotin-[acetylCoA carboxylase] holoenzyme synthetase/transcriptional repressor; COG0340 Biotin-(acetyl-CoA carboxylase) ligase. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.910 |
| ahcY | AGS07057.1 | SSDC_01850 | SSDC_01865 | S-adenosylhomocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | Bifunctional biotin-[acetylCoA carboxylase] holoenzyme synthetase/transcriptional repressor; COG0340 Biotin-(acetyl-CoA carboxylase) ligase. | 0.528 |
| ahcY | dnaJ | SSDC_01850 | SSDC_01120 | S-adenosylhomocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | 0.587 |
| ahcY | glyA | SSDC_01850 | SSDC_01580 | S-adenosylhomocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.693 |
| ahcY | metK | SSDC_01850 | SSDC_01855 | S-adenosylhomocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.961 |
| ahcY | ribAB | SSDC_01850 | SSDC_00885 | S-adenosylhomocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | Bifunctional riboflavin biosynthesis protein; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.511 |
| ahcY | ribD | SSDC_01850 | SSDC_01345 | S-adenosylhomocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.816 |
| dnaJ | AGS06699.1 | SSDC_01120 | SSDC_00010 | Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | NAD-dependent epimerase/dehydratase; COG0451 Nucleoside-diphosphate-sugar epimerases. | 0.726 |
| dnaJ | ahcY | SSDC_01120 | SSDC_01850 | Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | S-adenosylhomocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.587 |
| dnaJ | groL | SSDC_01120 | SSDC_01585 | Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.973 |
