gmk protein (Legionella waltersii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

gmk

Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (209 aa)

Predicted Functional Partners:

rpoZ

0.988

guaA

0.969

spoT

0.953

ppt

0.941

YicC

0.937

rir1

0.937

ndk

0.932

pykA

0.923

Lwal_0106

0.916

eno

0.912

Your Current Organism:

Legionella waltersii

NCBI taxonomy Id: 66969
Other names: ATCC 51914, CCUG 44924, CIP 104965, DSM 21908, L. waltersii, NCTC 13017, strain 2074-AUS-E

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Lwal_0106	gmk	Lwal_0106	Lwal_0159	ecto-ATP diphosphohydrolase II.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.916
Lwal_0106	guaA	Lwal_0106	Lwal_1883	ecto-ATP diphosphohydrolase II.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.900
Lwal_0106	ndk	Lwal_0106	Lwal_3089	ecto-ATP diphosphohydrolase II.	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	0.900
Lwal_0106	ppt	Lwal_0106	Lwal_3120	ecto-ATP diphosphohydrolase II.	Hypoxanthine-guanine phosphoribosyltransferase.	0.900
Lwal_0106	pykA	Lwal_0106	Lwal_2368	ecto-ATP diphosphohydrolase II.	Pyruvate kinase II; Belongs to the pyruvate kinase family.	0.900
Lwal_0106	rir1	Lwal_0106	Lwal_1835	ecto-ATP diphosphohydrolase II.	Ribonucleotide-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.900
Lwal_0106	spoT	Lwal_0106	Lwal_0157	ecto-ATP diphosphohydrolase II.	Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.	0.900
YicC	gmk	Lwal_0160	Lwal_0159	Putative stress-induced protein.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.937
YicC	rpoZ	Lwal_0160	Lwal_0158	Putative stress-induced protein.	RNA polymerase omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.	0.798
YicC	spoT	Lwal_0160	Lwal_0157	Putative stress-induced protein.	Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.	0.476
eno	gmk	Lwal_0564	Lwal_0159	Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.912
eno	guaA	Lwal_0564	Lwal_1883	Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.467
eno	ndk	Lwal_0564	Lwal_3089	Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	0.610
eno	pykA	Lwal_0564	Lwal_2368	Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.	Pyruvate kinase II; Belongs to the pyruvate kinase family.	0.995
eno	rir1	Lwal_0564	Lwal_1835	Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.	Ribonucleotide-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.449
eno	rpoZ	Lwal_0564	Lwal_0158	Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.	RNA polymerase omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.	0.786
gmk	Lwal_0106	Lwal_0159	Lwal_0106	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	ecto-ATP diphosphohydrolase II.	0.916
gmk	YicC	Lwal_0159	Lwal_0160	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Putative stress-induced protein.	0.937
gmk	eno	Lwal_0159	Lwal_0564	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.	0.912
gmk	guaA	Lwal_0159	Lwal_1883	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.969