Lwal_0190 protein (Legionella waltersii) - STRING interaction network

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Score

Lwal_0190

Substrate of the Dot/Icm secretion system. (226 aa)

Predicted Functional Partners:

dnaK

0.968

EryA

0.941

Lwal_2663

0.922

htpG

0.909

grpE

0.823

rplQ

0.752

ppiB

0.751

rplM

0.738

rplO

0.738

rplK

0.733

Your Current Organism:

Legionella waltersii

NCBI taxonomy Id: 66969
Other names: ATCC 51914, CCUG 44924, CIP 104965, DSM 21908, L. waltersii, NCTC 13017, strain 2074-AUS-E

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EryA	Lwal_0190	Lwal_0942	Lwal_0190	Polyketide synthase module.	Substrate of the Dot/Icm secretion system.	0.941
EryA	Lwal_2663	Lwal_0942	Lwal_2663	Polyketide synthase module.	Saframycin Mx1 synthetase B.	0.999
EryA	dnaK	Lwal_0942	Lwal_0550	Polyketide synthase module.	Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.634
EryA	grpE	Lwal_0942	Lwal_0551	Polyketide synthase module.	Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...]	0.442
EryA	htpG	Lwal_0942	Lwal_0808	Polyketide synthase module.	Heat shock protein 90; Molecular chaperone. Has ATPase activity.	0.697
EryA	ppiB	Lwal_0942	Lwal_1401	Polyketide synthase module.	Peptidyl-prolyl cis-trans isomerase B; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.951
EryA	rplK	Lwal_0942	Lwal_0967	Polyketide synthase module.	50S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.	0.950
EryA	rplM	Lwal_0942	Lwal_1380	Polyketide synthase module.	50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.	0.971
EryA	rplO	Lwal_0942	Lwal_2399	Polyketide synthase module.	50S ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family.	0.926
EryA	rplQ	Lwal_0942	Lwal_2405	Polyketide synthase module.	50S ribosomal protein L17.	0.934
Lwal_0190	EryA	Lwal_0190	Lwal_0942	Substrate of the Dot/Icm secretion system.	Polyketide synthase module.	0.941
Lwal_0190	Lwal_2663	Lwal_0190	Lwal_2663	Substrate of the Dot/Icm secretion system.	Saframycin Mx1 synthetase B.	0.922
Lwal_0190	dnaK	Lwal_0190	Lwal_0550	Substrate of the Dot/Icm secretion system.	Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.968
Lwal_0190	grpE	Lwal_0190	Lwal_0551	Substrate of the Dot/Icm secretion system.	Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...]	0.823
Lwal_0190	htpG	Lwal_0190	Lwal_0808	Substrate of the Dot/Icm secretion system.	Heat shock protein 90; Molecular chaperone. Has ATPase activity.	0.909
Lwal_0190	ppiB	Lwal_0190	Lwal_1401	Substrate of the Dot/Icm secretion system.	Peptidyl-prolyl cis-trans isomerase B; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.751
Lwal_0190	rplK	Lwal_0190	Lwal_0967	Substrate of the Dot/Icm secretion system.	50S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.	0.733
Lwal_0190	rplM	Lwal_0190	Lwal_1380	Substrate of the Dot/Icm secretion system.	50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.	0.738
Lwal_0190	rplO	Lwal_0190	Lwal_2399	Substrate of the Dot/Icm secretion system.	50S ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family.	0.738
Lwal_0190	rplQ	Lwal_0190	Lwal_2405	Substrate of the Dot/Icm secretion system.	50S ribosomal protein L17.	0.752