Lwal_0218 protein (Legionella waltersii) - STRING interaction network

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Score

Lwal_0218

LPS biosynthesis protein, PseA-like protein. (386 aa)

Predicted Functional Partners:

hisI

0.999

hisB

0.982

hisH_1

0.852

hisH_2

0.824

hisH_3

0.813

neuC

0.794

hisA

0.778

hisD

0.778

hisG

0.778

SpsE

0.758

Your Current Organism:

Legionella waltersii

NCBI taxonomy Id: 66969
Other names: ATCC 51914, CCUG 44924, CIP 104965, DSM 21908, L. waltersii, NCTC 13017, strain 2074-AUS-E

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Lwal_0218	SpsE	Lwal_0218	Lwal_0203	LPS biosynthesis protein, PseA-like protein.	N-acetylneuraminic acid synthetase.	0.758
Lwal_0218	hisA	Lwal_0218	Lwal_0428	LPS biosynthesis protein, PseA-like protein.	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.	0.778
Lwal_0218	hisB	Lwal_0218	Lwal_0430	LPS biosynthesis protein, PseA-like protein.	Imidazole glycerol-phosphate dehydratase/histidinol phosphatase; In the N-terminal section; belongs to the histidinol- phosphatase family.	0.982
Lwal_0218	hisD	Lwal_0218	Lwal_0432	LPS biosynthesis protein, PseA-like protein.	Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.	0.778
Lwal_0218	hisG	Lwal_0218	Lwal_0433	LPS biosynthesis protein, PseA-like protein.	ATP phosphoribosyltransferase HisG; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily.	0.778
Lwal_0218	hisH_1	Lwal_0218	Lwal_0201	LPS biosynthesis protein, PseA-like protein.	Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.	0.852
Lwal_0218	hisH_2	Lwal_0218	Lwal_0238	LPS biosynthesis protein, PseA-like protein.	Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.	0.824
Lwal_0218	hisH_3	Lwal_0218	Lwal_0429	LPS biosynthesis protein, PseA-like protein.	Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.	0.813
Lwal_0218	hisI	Lwal_0218	Lwal_0426	LPS biosynthesis protein, PseA-like protein.	Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; In the N-terminal section; belongs to the PRA-CH family.	0.999
Lwal_0218	neuC	Lwal_0218	Lwal_0204	LPS biosynthesis protein, PseA-like protein.	N-acylglucosamine 2-epimerase.	0.794
SpsE	Lwal_0218	Lwal_0203	Lwal_0218	N-acetylneuraminic acid synthetase.	LPS biosynthesis protein, PseA-like protein.	0.758
SpsE	hisH_1	Lwal_0203	Lwal_0201	N-acetylneuraminic acid synthetase.	Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.	0.715
SpsE	neuC	Lwal_0203	Lwal_0204	N-acetylneuraminic acid synthetase.	N-acylglucosamine 2-epimerase.	0.996
hisA	Lwal_0218	Lwal_0428	Lwal_0218	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.	LPS biosynthesis protein, PseA-like protein.	0.778
hisA	hisB	Lwal_0428	Lwal_0430	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.	Imidazole glycerol-phosphate dehydratase/histidinol phosphatase; In the N-terminal section; belongs to the histidinol- phosphatase family.	0.999
hisA	hisD	Lwal_0428	Lwal_0432	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.	Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.	0.998
hisA	hisG	Lwal_0428	Lwal_0433	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.	ATP phosphoribosyltransferase HisG; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily.	0.997
hisA	hisH_1	Lwal_0428	Lwal_0201	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.	Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.	0.995
hisA	hisH_2	Lwal_0428	Lwal_0238	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.	Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.	0.995
hisA	hisH_3	Lwal_0428	Lwal_0429	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.	Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.	0.998