ClpA protein (Legionella waltersii) - STRING interaction network

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Score

ClpA

ATP binding protease component ClpA; Belongs to the ClpA/ClpB family. (755 aa)

Predicted Functional Partners:

clpS

0.987

dnaK

0.984

clpP

0.969

grpE

0.869

Lwal_1914

0.816

htpG

0.804

Lwal_1916

0.804

lon

0.774

dnaJ_1

0.754

groES

0.753

Your Current Organism:

Legionella waltersii

NCBI taxonomy Id: 66969
Other names: ATCC 51914, CCUG 44924, CIP 104965, DSM 21908, L. waltersii, NCTC 13017, strain 2074-AUS-E

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ClpA	Lwal_1914	Lwal_0285	Lwal_1914	ATP binding protease component ClpA; Belongs to the ClpA/ClpB family.	Heat shock protein, Hsp20 family; Belongs to the small heat shock protein (HSP20) family.	0.816
ClpA	Lwal_1916	Lwal_0285	Lwal_1916	ATP binding protease component ClpA; Belongs to the ClpA/ClpB family.	Heat shock hsp20; Belongs to the small heat shock protein (HSP20) family.	0.804
ClpA	clpP	Lwal_0285	Lwal_3305	ATP binding protease component ClpA; Belongs to the ClpA/ClpB family.	ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	0.969
ClpA	clpS	Lwal_0285	Lwal_0284	ATP binding protease component ClpA; Belongs to the ClpA/ClpB family.	ATP-dependent Clp protease adaptor protein ClpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family.	0.987
ClpA	dnaJ_1	Lwal_0285	Lwal_0549	ATP binding protease component ClpA; Belongs to the ClpA/ClpB family.	Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...]	0.754
ClpA	dnaK	Lwal_0285	Lwal_0550	ATP binding protease component ClpA; Belongs to the ClpA/ClpB family.	Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.984
ClpA	groES	Lwal_0285	Lwal_2801	ATP binding protease component ClpA; Belongs to the ClpA/ClpB family.	Co-chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	0.753
ClpA	grpE	Lwal_0285	Lwal_0551	ATP binding protease component ClpA; Belongs to the ClpA/ClpB family.	Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...]	0.869
ClpA	htpG	Lwal_0285	Lwal_0808	ATP binding protease component ClpA; Belongs to the ClpA/ClpB family.	Heat shock protein 90; Molecular chaperone. Has ATPase activity.	0.804
ClpA	lon	Lwal_0285	Lwal_3303	ATP binding protease component ClpA; Belongs to the ClpA/ClpB family.	ATP-dependent Lon protease; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.	0.774
Lwal_1914	ClpA	Lwal_1914	Lwal_0285	Heat shock protein, Hsp20 family; Belongs to the small heat shock protein (HSP20) family.	ATP binding protease component ClpA; Belongs to the ClpA/ClpB family.	0.816
Lwal_1914	dnaK	Lwal_1914	Lwal_0550	Heat shock protein, Hsp20 family; Belongs to the small heat shock protein (HSP20) family.	Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.667
Lwal_1914	grpE	Lwal_1914	Lwal_0551	Heat shock protein, Hsp20 family; Belongs to the small heat shock protein (HSP20) family.	Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...]	0.513
Lwal_1914	htpG	Lwal_1914	Lwal_0808	Heat shock protein, Hsp20 family; Belongs to the small heat shock protein (HSP20) family.	Heat shock protein 90; Molecular chaperone. Has ATPase activity.	0.665
Lwal_1914	lon	Lwal_1914	Lwal_3303	Heat shock protein, Hsp20 family; Belongs to the small heat shock protein (HSP20) family.	ATP-dependent Lon protease; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.	0.459
Lwal_1916	ClpA	Lwal_1916	Lwal_0285	Heat shock hsp20; Belongs to the small heat shock protein (HSP20) family.	ATP binding protease component ClpA; Belongs to the ClpA/ClpB family.	0.804
Lwal_1916	dnaK	Lwal_1916	Lwal_0550	Heat shock hsp20; Belongs to the small heat shock protein (HSP20) family.	Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.661
Lwal_1916	grpE	Lwal_1916	Lwal_0551	Heat shock hsp20; Belongs to the small heat shock protein (HSP20) family.	Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...]	0.513
Lwal_1916	htpG	Lwal_1916	Lwal_0808	Heat shock hsp20; Belongs to the small heat shock protein (HSP20) family.	Heat shock protein 90; Molecular chaperone. Has ATPase activity.	0.657
Lwal_1916	lon	Lwal_1916	Lwal_3303	Heat shock hsp20; Belongs to the small heat shock protein (HSP20) family.	ATP-dependent Lon protease; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.	0.419