pfp protein (Legionella waltersii) - STRING interaction network

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pfp

6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (412 aa)

Predicted Functional Partners:

pgi

0.994

guaA

0.975

pykA

0.963

eno

0.945

alf1

0.944

TktA

0.941

rfbA

0.934

tpiA

0.873

pgk

0.835

gacS/letS

0.834

Your Current Organism:

Legionella waltersii

NCBI taxonomy Id: 66969
Other names: ATCC 51914, CCUG 44924, CIP 104965, DSM 21908, L. waltersii, NCTC 13017, strain 2074-AUS-E

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
TktA	alf1	Lwal_2371	Lwal_2506	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	Fructose bisphosphate aldolase.	0.936
TktA	eno	Lwal_2371	Lwal_0564	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.	0.962
TktA	guaA	Lwal_2371	Lwal_1883	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.504
TktA	pfp	Lwal_2371	Lwal_0617	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.	0.941
TktA	pgi	Lwal_2371	Lwal_0229	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.985
TktA	pgk	Lwal_2371	Lwal_2369	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.	0.929
TktA	pykA	Lwal_2371	Lwal_2368	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	Pyruvate kinase II; Belongs to the pyruvate kinase family.	0.975
TktA	rfbA	Lwal_2371	Lwal_2114	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	Phosphomannose isomerase GDP mannose pyrophosphorylase; Belongs to the mannose-6-phosphate isomerase type 2 family.	0.500
TktA	tpiA	Lwal_2371	Lwal_1989	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family.	0.933
alf1	TktA	Lwal_2506	Lwal_2371	Fructose bisphosphate aldolase.	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	0.936
alf1	eno	Lwal_2506	Lwal_0564	Fructose bisphosphate aldolase.	Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.	0.908
alf1	pfp	Lwal_2506	Lwal_0617	Fructose bisphosphate aldolase.	6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.	0.944
alf1	pgi	Lwal_2506	Lwal_0229	Fructose bisphosphate aldolase.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.946
alf1	pgk	Lwal_2506	Lwal_2369	Fructose bisphosphate aldolase.	Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.	0.538
alf1	pykA	Lwal_2506	Lwal_2368	Fructose bisphosphate aldolase.	Pyruvate kinase II; Belongs to the pyruvate kinase family.	0.878
alf1	tpiA	Lwal_2506	Lwal_1989	Fructose bisphosphate aldolase.	Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family.	0.955
eno	TktA	Lwal_0564	Lwal_2371	Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	0.962
eno	alf1	Lwal_0564	Lwal_2506	Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.	Fructose bisphosphate aldolase.	0.908
eno	guaA	Lwal_0564	Lwal_1883	Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.467
eno	pfp	Lwal_0564	Lwal_0617	Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.	6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.	0.945

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