gltA protein (Legionella waltersii) - STRING interaction network

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Score

gltA

Citrate synthase; Belongs to the citrate synthase family. (423 aa)

Predicted Functional Partners:

acnA

0.996

mdh

0.993

fumC

0.965

AceF

0.962

aceB

0.952

korA

0.949

sucC

0.937

acsB

0.936

atoB

0.935

PcaF_2

0.935

Your Current Organism:

Legionella waltersii

NCBI taxonomy Id: 66969
Other names: ATCC 51914, CCUG 44924, CIP 104965, DSM 21908, L. waltersii, NCTC 13017, strain 2074-AUS-E

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AceF	PcaF_2	Lwal_3136	Lwal_3046	Pyruvate dehydrogenase E2 component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.916
AceF	aceB	Lwal_3136	Lwal_0457	Pyruvate dehydrogenase E2 component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	Malate synthase A.	0.908
AceF	acsB	Lwal_3136	Lwal_2357	Pyruvate dehydrogenase E2 component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.	0.907
AceF	atoB	Lwal_3136	Lwal_1777	Pyruvate dehydrogenase E2 component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	Acyl CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.916
AceF	fumC	Lwal_3136	Lwal_2155	Pyruvate dehydrogenase E2 component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.	0.450
AceF	gltA	Lwal_3136	Lwal_0763	Pyruvate dehydrogenase E2 component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	Citrate synthase; Belongs to the citrate synthase family.	0.962
AceF	korA	Lwal_3136	Lwal_0129	Pyruvate dehydrogenase E2 component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	2-oxoglutarate ferredoxin oxidoreductase subunit alpha.	0.927
AceF	mdh	Lwal_3136	Lwal_1174	Pyruvate dehydrogenase E2 component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.	0.401
AceF	sucC	Lwal_3136	Lwal_2613	Pyruvate dehydrogenase E2 component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	Succinyl CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.968
PcaF_2	AceF	Lwal_3046	Lwal_3136	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Pyruvate dehydrogenase E2 component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.916
PcaF_2	aceB	Lwal_3046	Lwal_0457	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Malate synthase A.	0.914
PcaF_2	acnA	Lwal_3046	Lwal_3213	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.	0.526
PcaF_2	acsB	Lwal_3046	Lwal_2357	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.	0.929
PcaF_2	atoB	Lwal_3046	Lwal_1777	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Acyl CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.920
PcaF_2	gltA	Lwal_3046	Lwal_0763	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Citrate synthase; Belongs to the citrate synthase family.	0.935
PcaF_2	korA	Lwal_3046	Lwal_0129	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	2-oxoglutarate ferredoxin oxidoreductase subunit alpha.	0.928
PcaF_2	sucC	Lwal_3046	Lwal_2613	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Succinyl CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.853
aceB	AceF	Lwal_0457	Lwal_3136	Malate synthase A.	Pyruvate dehydrogenase E2 component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.908
aceB	PcaF_2	Lwal_0457	Lwal_3046	Malate synthase A.	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.914
aceB	acsB	Lwal_0457	Lwal_2357	Malate synthase A.	Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.	0.934