Mta protein (Legionella waltersii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

Mta

GTP cyclohydrolase. (158 aa)

Predicted Functional Partners:

queE

0.892

Lwal_2090

0.862

queC

0.776

rpoB

0.742

dnaJ_3

0.686

Lwal_0020

0.644

YhhQ

0.644

Lwal_2103

0.644

Lwal_0190

0.635

dnaJ_1

0.635

Your Current Organism:

Legionella waltersii

NCBI taxonomy Id: 66969
Other names: ATCC 51914, CCUG 44924, CIP 104965, DSM 21908, L. waltersii, NCTC 13017, strain 2074-AUS-E

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Lwal_0020	Mta	Lwal_0020	Lwal_1061	Hypothetical protein.	GTP cyclohydrolase.	0.644
Lwal_0190	Mta	Lwal_0190	Lwal_1061	Substrate of the Dot/Icm secretion system.	GTP cyclohydrolase.	0.635
Lwal_2090	Mta	Lwal_2090	Lwal_1061	6-pyruvoyl tetrahydropterin synthase.	GTP cyclohydrolase.	0.862
Lwal_2090	queC	Lwal_2090	Lwal_2113	6-pyruvoyl tetrahydropterin synthase.	ExsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family.	0.954
Lwal_2090	queE	Lwal_2090	Lwal_0078	6-pyruvoyl tetrahydropterin synthase.	Radical activating enzyme; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.	0.994
Lwal_2103	Mta	Lwal_2103	Lwal_1061	Hypothetical protein.	GTP cyclohydrolase.	0.644
Mta	Lwal_0020	Lwal_1061	Lwal_0020	GTP cyclohydrolase.	Hypothetical protein.	0.644
Mta	Lwal_0190	Lwal_1061	Lwal_0190	GTP cyclohydrolase.	Substrate of the Dot/Icm secretion system.	0.635
Mta	Lwal_2090	Lwal_1061	Lwal_2090	GTP cyclohydrolase.	6-pyruvoyl tetrahydropterin synthase.	0.862
Mta	Lwal_2103	Lwal_1061	Lwal_2103	GTP cyclohydrolase.	Hypothetical protein.	0.644
Mta	YhhQ	Lwal_1061	Lwal_0609	GTP cyclohydrolase.	Membrane protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.	0.644
Mta	dnaJ_1	Lwal_1061	Lwal_0549	GTP cyclohydrolase.	Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...]	0.635
Mta	dnaJ_3	Lwal_1061	Lwal_2861	GTP cyclohydrolase.	Chaperone protein DnaJ.	0.686
Mta	queC	Lwal_1061	Lwal_2113	GTP cyclohydrolase.	ExsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family.	0.776
Mta	queE	Lwal_1061	Lwal_0078	GTP cyclohydrolase.	Radical activating enzyme; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.	0.892
Mta	rpoB	Lwal_1061	Lwal_0971	GTP cyclohydrolase.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.742
YhhQ	Mta	Lwal_0609	Lwal_1061	Membrane protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.	GTP cyclohydrolase.	0.644
dnaJ_1	Mta	Lwal_0549	Lwal_1061	Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...]	GTP cyclohydrolase.	0.635
dnaJ_1	rpoB	Lwal_0549	Lwal_0971	Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...]	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.434
dnaJ_3	Mta	Lwal_2861	Lwal_1061	Chaperone protein DnaJ.	GTP cyclohydrolase.	0.686